Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART

Distinct gut microbiota profile in ART-treated perinatally HIV-infected patients associated with cardiac and inflammatory biomarkers

(2019) Libera Sessa et al.   AIDS

Biochemical and inflammatory modifications after switching to dual antiretroviral therapy in HIV-infected patients in Italy: a multicenter retrospective cohort study from 2007 to 2015

(2018) Eugenia Quiros-Roldan et al.   BMC INFECTIOUS DISEASES

HIV disease is associated with increased biomarkers of endothelial dysfunction despite viral suppression on long-term antiretroviral therapy in Botswana

(2018) Mosepele Mosepele et al.   Cardiovascular Journal of Africa

Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0

(2018) L Ryom et al.   HIV MEDICINE

Hypertension in HIV-Infected Adults

(2018) Sasha A. Fahme et al.   HYPERTENSION

Early and Highly Suppressive ART are Main Factors Associated with Low Viral Reservoir in European Perinatally HIV Infected Children

(2018) Alfredo Tagarro et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV

(2018) Suman Srinivasa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Altered immune cell follicular dynamics in HIV infection following influenza vaccination

(2018) Eirini Moysi et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal Integrity Biomarkers in Early Antiretroviral-Treated Perinatally HIV-1–Infected Infants

(2018) Wei Li A Koay et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolic syndrome in HIV infected adults in Poland

(2018) Magdalena Rogalska-Płońska et al.   Kardiologia Polska

Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies

(2018) Josep M Llibre et al.   LANCET

Cardiovascular disease in women living with HIV: A narrative review

(2018) Danielle Solomon et al.   MATURITAS

Dyslipidemia, chronic inflammation, and subclinical atherosclerosis in children and adolescents infected with HIV: The PositHIVe Health Study

(2018) Luiz Rodrigo Augustemak de Lima et al.   PLoS One

Prevalence and predictors of metabolic syndrome among people living with human immunodeficiency virus (PLWHIV)

(2018) Dula Dessalegn Bosho et al.   Diabetology & Metabolic Syndrome

Immune Activation, Proinflammatory Cytokines, and Conventional Risks for Cardiovascular Disease in HIV Patients: A Case-Control Study in Bahia, Brazil

(2018) Clara Brites-Alves et al.   Frontiers in Immunology

Factors Associated With Persistence of Plasma HIV-1 RNA During Long-term Continuously Suppressive Firstline Antiretroviral Therapy

(2018) Alessandra Ruggiero et al.   Open Forum Infectious Diseases

The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus

(2018) Edith Phalane et al.   SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE

Inflammation and Metabolic Complications in HIV

(2018) Kassem Bourgi et al.   Current HIV/AIDS Reports

Changes in cardiovascular risk and clinical outcomes in a HIV/AIDS cohort study over a 1-year period at a specialized clinic in Mexico

(2018) Angelica Cibrián-Ponce et al.   Therapeutics and Clinical Risk Management

Insulin Resistance in HIV-Patients: Causes and Consequences

(2018) Marcelo N. Pedro et al.   Frontiers in Endocrinology

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms

(2018) Elena Chiappini et al.   Aging-US

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials

(2018) Pedro Cahn et al.   LANCET

Metabolic risk factors in young adults infected with HIV since childhood compared with the general population

(2018) Elise Arrive et al.   PLoS One

Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection

(2018) Hury Hellen Souza de Paula et al.   Retrovirology

Predictive factors associated with liver fibrosis and steatosis by transient elastography in patients with HIV mono-infection under long-term combined antiretroviral therapy

(2018) Hugo Perazzo et al.   Journal of the International AIDS Society

The immune response to Prevotella bacteria in chronic inflammatory disease

(2017) Jeppe Madura Larsen   IMMUNOLOGY

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1– and Combination Antiretroviral Therapy–Exposed Infants

(2017) Johannes C Schoeman et al.   JOURNAL OF INFECTIOUS DISEASES

Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men

(2017) David B. Hanna et al.   JOURNAL OF INFECTIOUS DISEASES

Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy

(2017) Timothy J Henrich et al.   JOURNAL OF INFECTIOUS DISEASES

Greater Risk of Stroke of Undetermined Etiology in a Contemporary HIV-Infected Cohort Compared with Uninfected Individuals

(2017) Felicia C. Chow et al.   Journal of Stroke & Cerebrovascular Diseases

Global prevalence of hypertension among people living with HIV: a systematic review and meta-analysis

(2017) Yunan Xu et al.   Journal of the American Society of Hypertension

HIV as a Cause of Immune Activation and Immunosenescence

(2017) T. Sokoya et al.   MEDIATORS OF INFLAMMATION

Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

(2017) Adrien De Voeght et al.   PLoS One

Metabolic disorders and cardiovascular risk in people living with HIV/AIDS without the use of antiretroviral therapy

(2017) Mariana Amaral Raposo et al.   Revista da Sociedade Brasileira de Medicina Tropical

Linkage to HIV care after home-based HIV counselling and testing in sub-Saharan Africa: a systematic review

(2017) Eugene Ruzagira et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria

(2017) Kim Anh Nguyen et al.   International Journal of Endocrinology

HIV-associated malignancies in children

(2017) Elvira Singh et al.   Current Opinion in HIV and AIDS

Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction

(2017) Ekaterina Maidji et al.   PLoS Pathogens

Greater Risk of Stroke of Undetermined Etiology in a Contemporary HIV-Infected Cohort Compared with Uninfected Individuals

(2017) Felicia C. Chow et al.   Journal of Stroke & Cerebrovascular Diseases

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

(2017) Jordan E. Lake   Current HIV/AIDS Reports

Perturbation of B Cell Gene Expression Persists in HIV-Infected Children Despite Effective Antiretroviral Therapy and Predicts H1N1 Response

(2017) Nicola Cotugno et al.   Frontiers in Immunology

Immune activation despite preserved CD4 T cells in perinatally HIV-infected children and adolescents

(2017) Patricia Alvarez et al.   PLoS One

Premature aging and immune senescence in HIV-infected children

(2016) Ketty Gianesin et al.   AIDS

Early antiretroviral treatment (eART) limits viral diversity over time in a long-term HIV viral suppressed perinatally infected child

(2016) Paolo Palma et al.   BMC INFECTIOUS DISEASES

HIV-associated changes in the enteric microbial community

(2016) David B. Gootenberg et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Strategies to limit immune-activation in HIV patients

(2016) Alessandra Bandera et al.   Expert Review of Anti-Infective Therapy

The Protease Inhibitor Monotherapy Versus Ongoing Triple Therapy (PIVOT) trial: a randomised controlled trial of a protease inhibitor monotherapy strategy for long-term management of human immunodeficiency virus infection

(2016) Nicholas I Paton et al.   HEALTH TECHNOLOGY ASSESSMENT

HIV and aging

(2016) Edward J. Wing   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1–Infected Individuals

(2016) Troels Bygum Knudsen et al.   JOURNAL OF INFECTIOUS DISEASES

Cytokines and T-Cell Homeostasis in HIV Infection

(2016) Michael L. Freeman et al.   JOURNAL OF INFECTIOUS DISEASES

Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection

(2016) Sara Gianella et al.   JOURNAL OF VIROLOGY

Dysfunctional phenotypes of CD4+ and CD8+ T cells are comparable in patients initiating ART during early or chronic HIV-1 infection

(2016) Sylvie Amu et al.   MEDICINE

Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection

(2016) D Paquin-Proulx et al.   Mucosal Immunology

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV-infected individuals

(2016) Thandiwe Manjati et al.   SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE

Immune activation and paediatric HIV-1 disease outcome

(2016) Julia M. Roider et al.   Current Opinion in HIV and AIDS

Microbial translocation and microbiome dysbiosis in HIV-associated immune activation

(2016) Alexander S. Zevin et al.   Current Opinion in HIV and AIDS

Assessing immune aging in HIV-infected patients

(2016) Victor Appay et al.   Virulence

Metabolic and Cardiovascular Complications in HIV/HCV-Co-infected Patients

(2016) Roger Bedimo et al.   Current HIV/AIDS Reports

The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough?

(2016) Sulggi A. Lee et al.   EBioMedicine

Prevalence of Hypertension in HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART) Compared with HAART-Naïve Patients at the Limbe Regional Hospital, Cameroon

(2016) Christian Akem Dimala et al.   PLoS One

A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population

(2016) Kim A. Nguyen et al.   PLoS One

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

(2016) Birgit Grund et al.   PLoS One

The metabolic and cardiovascular consequences of obesity in persons with HIV on long-term antiretroviral therapy

(2015) John R. Koethe et al.   AIDS

Endothelial activation and cardiometabolic profiles of treated and never-treated HIV infected Africans

(2015) C.M.T. Fourie et al.   ATHEROSCLEROSIS

The effect of initiation of antiretroviral therapy on monocyte, endothelial and platelet function in HIV-1 infection

(2015) JA O'Halloran et al.   HIV MEDICINE

Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life

(2015) A Bamford et al.   HIV MEDICINE

Cancer Among Children With Perinatal Exposure to HIV and Antiretroviral Medications—New Jersey, 1995–2010

(2015) Wade Ivy et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine

(2015) Varghese K. George et al.   JOURNAL OF INFECTIOUS DISEASES

Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders

(2015) Katie Silva et al.   JOURNAL OF NEUROVIROLOGY

Hypertension—an emerging cardiovascular risk factor in HIV infection

(2015) Vicente Sperb Antonello et al.   Journal of the American Society of Hypertension

Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission

(2015) Nigel Klein et al.   LANCET INFECTIOUS DISEASES

The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients

(2015) K Allers et al.   Mucosal Immunology

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

(2015) Damalie Nakanjako et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities

(2015) David W. Haas et al.   Current Opinion in HIV and AIDS

Changes in HIV reservoirs during long-term antiretroviral therapy

(2015) Feiyu F. Hong et al.   Current Opinion in HIV and AIDS

HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings

(2015) Julia L Finkelstein et al.   Journal of the International AIDS Society

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

(2015) Alessandra Ruggiero et al.   EBioMedicine

Immune Activation Response in Chronic HIV-Infected Patients: Influence of Hepatitis C Virus Coinfection

(2015) Mercedes Márquez et al.   PLoS One

Absolute Leukocyte Telomere Length in HIV-Infected and Uninfected Individuals: Evidence of Accelerated Cell Senescence in HIV-Associated Chronic Obstructive Pulmonary Disease

(2015) Joseph C. Y. Liu et al.   PLoS One

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities

(2015) Mathilde Ghislain et al.   PLoS One

HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis

(2014) Francesca Caccuri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pediatric Human Immunodeficiency Virus infection and cancer in the Highly Active Antiretroviral Treatment (HAART) era

(2014) Elena Chiappini et al.   CANCER LETTERS

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection

(2014) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Lymphoid Fibrosis Occurs in Long-Term Nonprogressors and Persists With Antiretroviral Therapy but May Be Reversible With Curative Interventions

(2014) Joyce L. Sanchez et al.   JOURNAL OF INFECTIOUS DISEASES

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Cytomegalovirus Replication in Semen Is Associated with Higher Levels of Proviral HIV DNA and CD4+T Cell Activation during Antiretroviral Treatment

(2014) Sara Gianella et al.   JOURNAL OF VIROLOGY

Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals

(2014) J F Vázquez-Castellanos et al.   Mucosal Immunology

The Evolving Scenario of Non-AIDS-Defining Cancers: Challenges and Opportunities of Care

(2014) E. Vaccher et al.   ONCOLOGIST

Gut Microbiota in HIV Infection: Implication for Disease Progression and Management

(2014) Felix Chinweije Nwosu et al.   Gastroenterology Research and Practice

Premature B-cell senescence as a consequence of chronic immune activation

(2014) Paolo Palma et al.   Human Vaccines & Immunotherapeutics

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

(2014) Ece A. Mutlu et al.   PLoS Pathogens

Non-AIDS-Defining Malignancies in the HIV-Infected Population

(2014) Chia-ching J. Wang et al.   Current Infectious Disease Reports

Endothelial activation biomarkers increase after HIV-1 acquisition

(2013) Susan M. Graham et al.   AIDS

Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection

(2013) Chris T. Longenecker et al.   AIDS

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

(2013) Giulia Marchetti et al.   CLINICAL MICROBIOLOGY REVIEWS

Immunosenescent CD57+CD4+T-cells Accumulate and Contribute to Interferon-γResponses in HIV Patients Responding Stably to ART

(2013) Sonia Fernandez et al.   DISEASE MARKERS

Correlation Between Different Methods to Measure Microbial Translocation and Its Association With Immune Activation in Long-Term Suppressed HIV-1–Infected Individuals

(2013) María Abad-Fernández et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination

(2013) Alberto Cagigi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-Term Suppressive Combined Antiretroviral Treatment Does Not Normalize the Serum Level of Soluble CD14

(2013) G. Mendez-Lagares et al.   JOURNAL OF INFECTIOUS DISEASES

Raising Awareness of Non-Hodgkin Lymphoma in HIV-infected Adolescents

(2013) Paola Zangari et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

(2013) Ivan Vujkovic-Cvijin et al.   Science Translational Medicine

Factors contributing to risk for cancer among HIV-infected individuals, and evidence that earlier combination antiretroviral therapy will alter this risk

(2013) Álvaro H. Borges et al.   Current Opinion in HIV and AIDS

Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents

(2012) Roger Bedimo et al.   AIDS

Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors

(2012) Giuseppe Pontrelli et al.   BMC INFECTIOUS DISEASES

Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment

(2012) Nicola Cotugno et al.   Clinical & Developmental Immunology

Detectable Viral Load Aggravates Immunosenescence Features of CD8 T-Cell Subsets in Vertically HIV-Infected Children

(2012) Laura Díaz et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Effect of Phosphate Binders on Serum Inflammatory Profile, Soluble CD14, and Endotoxin Levels in Hemodialysis Patients

(2011) J. F. Navarro-Gonzalez et al.   Clinical Journal of the American Society of Nephrology

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble CD163 Made by Monocyte/Macrophages Is a Novel Marker of HIV Activity in Early and Chronic Infection Prior to and After Anti-retroviral Therapy

(2011) Tricia H. Burdo et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD4+ T Cell Depletion, Immune Activation and Increased Production of Regulatory T Cells in the Thymus of HIV-Infected Individuals

(2010) Alessandra Bandera et al.   PLoS One

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

Early Immune Senescence in HIV Disease

(2010) Seema Desai et al.   Current HIV/AIDS Reports

Growing Up with HIV: Children, Adolescents, and Young Adults with Perinatally Acquired HIV Infection

(2009) Rohan Hazra et al.   Annual Review of Medicine

Declines in Mortality Rates and Changes in Causes of Death in HIV-1-Infected Children During the HAART Era

(2009) Michael T Brady et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

(2009) Alison J. Rodger et al.   JOURNAL OF INFECTIOUS DISEASES

Effects of HIV Infection and Antiretroviral Therapy on the Heart and Vasculature

(2008) Michael P. Dubé et al.   CIRCULATION

Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life

(2008) Nazma Mansoor et al.   CLINICAL IMMUNOLOGY

Long‐Term Effects of Highly Active Antiretroviral Therapy on CD4+Cell Evolution among Children and Adolescents Infected with HIV: 5 Years and Counting

(2008) Kunjal Patel et al.   CLINICAL INFECTIOUS DISEASES

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen

(2008) C. Bourgeois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE