Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy

Sestrin‑2 regulates podocyte mitochondrial dysfunction�and apoptosis under high‑glucose conditions via AMPK

(2020) Qiaoxuan Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Xuesaitong Protects Podocytes from Apoptosis in Diabetic Rats through Modulating PTEN-PDK1-Akt-mTOR Pathway

(2020) Rui Xue et al.   Journal of Diabetes Research

A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

(2019) Xiaoqiao Wang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis

(2019) Tao Zhang et al.   MEDICAL SCIENCE MONITOR

Deregulation of long noncoding RNA (TUG1) contributes to excessive podocytes apoptosis by activating endoplasmic reticulum stress in the development of diabetic nephropathy

(2019) Hongchun Shen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1

(2019) Dong-Wei Liu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Sam68 mediates high glucose‑induced podocyte apoptosis through modulation of Bax/Bcl‑2

(2019) Yuyu Chen et al.   Molecular Medicine Reports

Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes

(2019) Jun Feng et al.   LIFE SCIENCES

Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury

(2019) Junjie Wang et al.   Molecular Medicine Reports

High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress

(2018) Jie Lei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Swiprosin-1 Promotes Mitochondria-Dependent Apoptosis of Glomerular Podocytes via P38 MAPK Pathway in Early-Stage Diabetic Nephropathy

(2018) Rong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

β-Arrestin 1/2 Aggravates Podocyte Apoptosis of Diabetic Nephropathy via Wnt/β-Catenin Pathway

(2018) Yao Wang et al.   MEDICAL SCIENCE MONITOR

Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy

(2018) Xiao-Bing Wang et al.   MEDICAL SCIENCE MONITOR

The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway

(2018) Lei Liu et al.   RENAL FAILURE

Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice

(2018) Xiaolei Wang et al.   Drug Design Development and Therapy

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression

(2018) Falguni Das et al.   PLoS One

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes

(2017) Yingli Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes

(2017) Xiaoming Wu et al.   Scientific Reports

Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression

(2017) Xiaofei An et al.   Scientific Reports

PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes

(2017) Hong-hong Zou et al.   Scientific Reports

Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy

(2017) Na Liu et al.   Journal of Diabetes Research

Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

(2017) Yun-peng Chang et al.   Frontiers in Pharmacology

CD2-associated protein/phosphoinositide 3-kinase signaling has a preventive role in angiotensin II-induced podocyte apoptosis

(2016) Hye-Young Park et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

(2016) Ai-Li Cao et al.   LABORATORY INVESTIGATION

Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injury

(2016) Wei Miaomiao et al.   Molecular BioSystems

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms

(2016) Luigi Gnudi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metadherin facilitates podocyte apoptosis in diabetic nephropathy

(2016) Wen-Ting Liu et al.   Cell Death & Disease

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy

(2016) J Liu et al.   Cell Death & Disease

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo

(2015) Tingfang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis

(2015) Ranjan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

A vital role for Angptl3 in the PAN-induced podocyte loss by affecting detachment and apoptosis in vitro

(2015) Rufeng Dai et al.   BMC Nephrology

VEGF-A Inhibition Ameliorates Podocyte Apoptosis via Repression of Activating Protein 1 in Diabetes

(2015) Xiaoyan Bai et al.   AMERICAN JOURNAL OF NEPHROLOGY

High glucose increases Cdk5 activity in podocytes via transforming growth factor-β1 signaling pathway

(2014) Yue Zhang et al.   EXPERIMENTAL CELL RESEARCH

A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD

(2014) W. Kriz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway

(2014) Caixia Li et al.   PLoS One

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

(2014) Yoshiro Maezawa et al.   Journal of Diabetes Investigation

The Role of SIRT1 in Diabetic Kidney Disease

(2014) Rabi Yacoub et al.   Frontiers in Endocrinology

Temporal Profile of Diabetic Nephropathy Pathologic Changes

(2013) Cecilia Ponchiardi et al.   Current Diabetes Reports

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

(2013) Assaad A. Eid et al.   DIABETES

High glucose induces autophagy in podocytes

(2013) Tean Ma et al.   EXPERIMENTAL CELL RESEARCH

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway

(2013) Guiying Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Roles of Na+/H+ Exchanger Type 1 and Intracellular pH in Angiotensin II-Induced Reactive Oxygen Species Generation and Podocyte Apoptosis

(2013) Ya Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

(2013) Kazuhiro Hasegawa et al.   NATURE MEDICINE

Sirt1 attenuates diabetic albuminuria

(2013) Ellen Bible   Nature Reviews Nephrology

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes

(2012) D. K. Kim et al.   DIABETOLOGIA

Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions

(2012) Zhimei Lv et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism

(2012) Wei Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways

(2012) Feng Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

How Many Ways Can a Podocyte Die?

(2012) Pierre-Louis Tharaux et al.   SEMINARS IN NEPHROLOGY

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Autophagy as a Therapeutic Target in Diabetic Nephropathy

(2011) Yuki Tanaka et al.   Experimental Diabetes Research

High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes

(2011) Agnieszka Piwkowska et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production

(2011) J. Toyonaga et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Integrins in renal development

(2011) Sijo Mathew et al.   PEDIATRIC NEPHROLOGY

Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK

(2010) Da-Fa Ding et al.   AMERICAN JOURNAL OF NEPHROLOGY

ANG II promotes autophagy in podocytes

(2010) Anju Yadav et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of integrin-linked kinase blocks podocyte epithelial–mesenchymal transition and ameliorates proteinuria

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF- 1 and p27Kip1: implications for diabetic nephropathy

(2010) M. Romero et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Selective types of autophagy in yeast

(2009) Claudine Kraft et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy?

(2009) Gaddameedi R Reddy et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

(2009) A. A. Eid et al.   DIABETES

Wnt/ -Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

(2009) C. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical forces and TGF 1 reduce podocyte adhesion through  3 1 integrin downregulation

(2009) C. Dessapt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of Taurine-Conjugated Ursodeoxycholic Acid on Endoplasmic Reticulum Stress and Apoptosis Induced by Advanced Glycation End Products in Cultured Mouse Podocytes

(2008) Yu Chen et al.   AMERICAN JOURNAL OF NEPHROLOGY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via α3β1 integrin upregulation and integrin-linked kinase inhibition

(2008) Jianguo Chen et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

(2008) Liping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced glycation end-products induce cell cycle arrest and hypertrophy in podocytes

(2008) C. Ruster et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Picky Eater: Exploring the Mechanisms of Selective Autophagy in Human Pathologies

(2008) Aniek van der Vaart et al.   TRAFFIC

Lost to translation: when autophagy targets mature ribosomes

(2008) Isabelle Beau et al.   TRENDS IN CELL BIOLOGY