Drosophila as a Model Organism in Host–Pathogen Interaction Studies

The Genetic Basis of Natural Variation in Drosophila melanogaster Immune Defense against Enterococcus faecalis

(2020) Joanne R Chapman et al.   Genes

The prophenoloxidase system in Drosophila participates in the anti-nematode immune response

(2019) Dustin Cooper et al.   MOLECULAR IMMUNOLOGY

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

(2019) Morgan Brisse et al.   Frontiers in Immunology

The peptidoglycan recognition protein PGRP-LE regulates the Drosophila immune response against the pathogen Photorhabdus

(2019) Victoria Chevée et al.   MICROBIAL PATHOGENESIS

Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids

(2019) Alexandre B. Leitão et al.   PLoS Pathogens

Identification of Regulatory Host Genes Involved in Sigma Virus Replication Using RNAi Knockdown in Drosophila

(2019) Liao et al.   Insects

Unexpected role of the IMD pathway in Drosophila gut defense against Staphylococcus aureus

(2018) Aki Hori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism

(2018) Layla Kamareddine et al.   Cell Metabolism

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells

(2018) Annemarthe G van der Veen et al.   EMBO JOURNAL

Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production

(2018) Alexander S. Little et al.   mBio

Drosophila melanogaster as a model for the study of Malassezia pachydermatis infections

(2018) Simone Merkel et al.   VETERINARY MICROBIOLOGY

The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria

(2018) Olivia Benguettat et al.   PLoS Pathogens

Dual comprehensive approach to decipher the Drosophila Toll pathway, ex vivo RNAi screenings and immunoprecipitation-mass spectrometry

(2018) Hirotaka Kanoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut

(2017) Tiffani Alvey Jones et al.   PLoS Pathogens

Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host

(2017) Layla Kamareddine et al.   Nature Microbiology

The FinR-regulated essential gene fprA, encoding ferredoxin NADP+ reductase: Roles in superoxide-mediated stress protection and virulence of Pseudomonas aeruginosa

(2017) Siriwan Boonma et al.   PLoS One

Oxylipins produced by Pseudomonas aeruginosa promote biofilm formation and virulence

(2016) Eriel Martínez et al.   Nature Communications

Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq

(2015) Julio C. Castillo et al.   BMC GENOMICS

JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection

(2015) H. Yang et al.   EMBO REPORTS

E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses

(2015) Andrei E. Medvedev et al.   IMMUNOLOGICAL REVIEWS

The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster

(2015) A. J. Bretscher et al.   Biology Open

Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome

(2014) Elodie Engel et al.   Cell Communication and Signaling

A Roadmap to Understanding Toll Pathway Changes: An Educational Primer for Use with “Regulation of Toll Signaling and Inflammation by β-Arrestin and the SUMO Protease Ulp1”

(2014) Rebecca L. Schmidt   GENETICS

JAK/STAT Pathway inDrosophilaImmunity

(2014) H. Myllymäki et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cholera Toxin Disrupts Barrier Function by Inhibiting Exocyst-Mediated Trafficking of Host Proteins to Intestinal Cell Junctions

(2013) Annabel Guichard et al.   Cell Host & Microbe

RNAi and antiviral defense in Drosophila: Setting up a systemic immune response

(2013) Margot Karlikow et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Regulation of Toll Signaling and Inflammation by  -Arrestin and the SUMO Protease Ulp1

(2013) S. G. Anjum et al.   GENETICS

The Drosophila Toll Pathway Controls but Does Not Clear Candida glabrata Infections

(2013) J. Quintin et al.   JOURNAL OF IMMUNOLOGY

Genome-Wide Transcriptional Analysis of Drosophila Larvae Infected by Entomopathogenic Nematodes Shows Involvement of Complement, Recognition and Extracellular Matrix Proteins

(2013) Badrul Arefin et al.   Journal of Innate Immunity

Drosophila melanogaster model for Mycobacterium abscessus infection

(2013) Chun-Taek Oh et al.   MICROBES AND INFECTION

Mutations in the IMD Pathway and Mustard Counter Vibrio cholerae Suppression of Intestinal Stem Cell Division in Drosophila

(2013) Z. Wang et al.   mBio

JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection

(2012) Hye-Mi Ahn et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Independent Recognition ofStaphylococcus aureusby Two Receptors for Phagocytosis inDrosophila

(2012) Akiko Shiratsuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad RNA Interference-Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila

(2012) C. Kemp et al.   JOURNAL OF IMMUNOLOGY

Immune gene transcription in Drosophila adult flies infected by entomopathogenic nematodes and their mutualistic bacteria

(2012) J.C. Castillo et al.   JOURNAL OF INSECT PHYSIOLOGY

Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway

(2012) P. N. Paradkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila as a model system to unravel the layers of innate immunity to infection

(2012) I. Kounatidis et al.   Open Biology

The Mosquito Melanization Response Is Implicated in Defense against the Entomopathogenic Fungus Beauveria bassiana

(2012) Hassan Yassine et al.   PLoS Pathogens

Natural Resistance-Associated Macrophage Protein Is a Cellular Receptor for Sindbis Virus in Both Insect and Mammalian Hosts

(2011) Patrick P. Rose et al.   Cell Host & Microbe

Deconstructing host-pathogen interactions in Drosophila

(2011) E. Bier et al.   Disease Models & Mechanisms

Shift in Ribonucleotide Reductase Gene Expression in Pseudomonas aeruginosa during Infection

(2011) Britt-Marie Sjöberg et al.   INFECTION AND IMMUNITY

Spn1 Regulates the GNBP3-Dependent Toll Signaling Pathway in Drosophila melanogaster

(2011) A. Fullaondo et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation

(2011) A. E. Purdy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wall Teichoic Acids of Staphylococcus aureus Limit Recognition by the Drosophila Peptidoglycan Recognition Protein-SA to Promote Pathogenicity

(2011) Magda L. Atilano et al.   PLoS Pathogens

Refinement of Tools for Targeted Gene Expression in Drosophila

(2010) B. D. Pfeiffer et al.   GENETICS

Porphyromonas gingivalisVirulence in aDrosophila melanogasterModel

(2010) Christina O. Igboin et al.   INFECTION AND IMMUNITY

Innate immunity in Drosophila: Pathogens and pathways

(2010) Shubha Govind   Insect Science

Inhibitory Role for D-Alanylation of Wall Teichoic Acid in Activation of Insect Toll Pathway by Peptidoglycan of Staphylococcus aureus

(2010) Y. Tabuchi et al.   JOURNAL OF IMMUNOLOGY

Exploring the concordance ofAspergillus fumigatuspathogenicity in mice andToll-deficient flies

(2010) Georgios Chamilos et al.   MEDICAL MYCOLOGY

Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens

(2010) Jean-Luc Aymeric et al.   MOLECULAR IMMUNOLOGY

Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

(2010) Annabel Guichard et al.   NATURE

Refined LexA transactivators and their use in combination with the Drosophila Gal4 system

(2010) R. Yagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Necrosis Factor (TNF)-α and TNF Receptors in Viral Pathogenesis

(2010) Georges Herbein et al.   PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE

Dissecting the immune response to the entomopathogen Photorhabdus

(2010) Ioannis Eleftherianos et al.   TRENDS IN MICROBIOLOGY

Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila

(2009) Leah R. Sabin et al.   CELL

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

The Drosophila Ubiquitin-Specific Protease dUSP36/Scny Targets IMD to Prevent Constitutive Immune Signaling

(2009) Dominique Thevenon et al.   Cell Host & Microbe

Drosophila Intestinal Response to Bacterial Infection: Activation of Host Defense and Stem Cell Proliferation

(2009) Nicolas Buchon et al.   Cell Host & Microbe

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus

(2009) Spencer Shelly et al.   IMMUNITY

Candida albicansCas5, a Regulator of Cell Wall Integrity, Is Required for Virulence in Murine andTollMutant Fly Models

(2009) Georgios Chamilos et al.   JOURNAL OF INFECTIOUS DISEASES

A Large-Scale RNAi Screen Identifies Deaf1 as a Regulator of Innate Immune Responses in Drosophila

(2009) David Kuttenkeuler et al.   Journal of Innate Immunity

Antiviral immunity in Drosophila requires systemic RNA interference spread

(2009) Maria-Carla Saleh et al.   NATURE

The Pathogenic Properties of a Novel and Conserved Gene Product, KerV, in Proteobacteria

(2009) Dingding An et al.   PLoS One

The Transcriptional Response of Drosophila melanogaster to Infection with the Sigma Virus (Rhabdoviridae)

(2009) Jennifer Carpenter et al.   PLoS One

The Imd Pathway Is Involved in Antiviral Immune Responses in Drosophila

(2009) Alexandre Costa et al.   PLoS One

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

(2009) N. Buchon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection

(2009) S. J. F. Cronin et al.   SCIENCE

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response

(2009) Vasanthi Avadhanula et al.   PLoS Pathogens

Undertaker, a Drosophila Junctophilin, Links Draper-Mediated Phagocytosis and Calcium Homeostasis

(2008) Leigh Cuttell et al.   CELL

Mechanism of Induction and Suppression of Antiviral Immunity Directed by Virus-Derived Small RNAs in Drosophila

(2008) Roghiyh Aliyari et al.   Cell Host & Microbe

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host–pathogen interactions?

(2008) Sara Cherry   CURRENT OPINION IN MICROBIOLOGY

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

(2008) Christoph Scherfer et al.   DEVELOPMENTAL BIOLOGY

A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila

(2008) Huaping Tang et al.   DEVELOPMENTAL CELL

Models of infectious diseases in the fruit fly Drosophila melanogaster

(2008) M. S. Dionne et al.   Disease Models & Mechanisms

Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization cascades in Drosophila

(2008) Rebecca L. Schmidt et al.   FASEB JOURNAL

Drosophila melanogaster-Based Screening for Multihost Virulence Factors of Pseudomonas aeruginosa PA14 and Identification of a Virulence-Attenuating Factor, HudA

(2008) S.-H. Kim et al.   INFECTION AND IMMUNITY

Cyanide Produced by Human Isolates ofPseudomonas aeruginosaContributes to Lethality inDrosophila melanogaster

(2008) Kate E. Broderick et al.   JOURNAL OF INFECTIOUS DISEASES

Gliotoxin Production inAspergillus fumigatusContributes to Host‐Specific Differences in Virulence

(2008) Sara Spikes et al.   JOURNAL OF INFECTIOUS DISEASES

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY

Rapid Virulence Annotation (RVA): Identification of virulence factors using a bacterial genome library and multiple invertebrate hosts

(2008) N. R. Waterfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for lysosomal enzyme -hexosaminidase in the control of mycobacteria infection

(2008) I. C. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis

(2008) G. Chamilos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proPO-system: pros and cons for its role in invertebrate immunity

(2008) Lage Cerenius et al.   TRENDS IN IMMUNOLOGY

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

(2008) Crystal M. Botham et al.   PLoS Pathogens