Journal
EMBO REPORTS
Volume 16, Issue 12, Pages 1664-1672Publisher
WILEY-BLACKWELL
DOI: 10.15252/embr.201540277
Keywords
Drosophila; innate immunity; JAK/STAT signaling; muscles
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Funding
- Swedish Research Council
- Swedish Cancer Society
- Academy of Finland
- Sigrid Juselius Foundation
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The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection.
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