RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma

Dihydroartemisinin, an antimalarial drug, induces absent in melanoma 2 inflammasome activation and autophagy in human hepatocellular carcinoma HepG2215 cells

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Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC

(2019) Yi Xue et al.   Frontiers in Oncology

Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification

(2018) Yutaka Kurebayashi et al.   HEPATOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Antimalarial Dihydroartemisinin Triggers Autophagy within HeLa Cells of Human Cervical Cancer through Bcl-2 Phosphorylation at Ser70

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RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

(2018) Giulia Zago et al.   eLife

The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

(2017) Xiaodong Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer

(2017) Chao Yan et al.   PHARMACOLOGICAL REVIEWS

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

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Inhibition of Ral GTPases Using a Stapled Peptide Approach

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Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis

(2016) Tong Wu et al.   Scientific Reports

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

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Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma

(2015) Maie A. St. John   LARYNGOSCOPE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs

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Degradation of the Deubiquitinating Enzyme USP33 Is Mediated by p97 and the Ubiquitin Ligase HERC2

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Discovery and characterization of small molecules that target the GTPase Ral

(2014) Chao Yan et al.   NATURE

Drugging the undruggable RAS: Mission Possible?

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Anticancer Properties of Distinct Antimalarial Drug Classes

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Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

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The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

(2013) Michal Simicek et al.   NATURE CELL BIOLOGY

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Sensing the Dark Side of DNA

(2013) L. A. J. O'Neill   SCIENCE

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Inflammasomes as molecular mediators of inflammation and cancer: Potential role in melanoma

(2011) Jeffrey H. Dunn et al.   CANCER LETTERS

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells

(2011) Xueting Cai et al.   TOXICOLOGY IN VITRO

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica

(2011) Urs Duthaler et al.   VETERINARY PARASITOLOGY

PYHIN proteins: center stage in DNA sensing

(2010) Delphine Goubau et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair

(2008) P. C.H. Li et al.   CANCER RESEARCH

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE