Anticancer Properties of Distinct Antimalarial Drug Classes

Dihydroartemisinin suppresses cell proliferation, invasion, and angiogenesis in human glioma U87 cells

(2012) Xiangrong Chen   African Journal of Pharmacy and Pharmacology

Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects

(2012) Moon-Suhn Ryu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

(2012) Chris Zhiyi Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis

(2012) Xiuli Zhang et al.   CELLULAR SIGNALLING

Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells

(2012) Chenjuan Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

(2012) Yassir Younis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

(2012) Pauline Byakika-Kibwika et al.   MALARIA JOURNAL

Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells

(2012) T. Eichhorn et al.   Molecular BioSystems

LyP-1 Modification To Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics

(2012) Zhaohui Wang et al.   MOLECULAR PHARMACEUTICS

Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5

(2012) Rui Kong et al.   PLoS One

Histone Deacetylase Inhibitors Facilitate Dihydroartemisinin-Induced Apoptosis in Liver Cancer In Vitro and In Vivo

(2012) Chris Zhiyi Zhang et al.   PLoS One

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

(2012) Y. Yuthavong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes

(2011) Antony S. Tin et al.   ANTI-CANCER DRUGS

Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo

(2011) Ning Gao et al.   APOPTOSIS

Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo

(2011) Shokoofe Noori et al.   CELLULAR IMMUNOLOGY

Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase

(2011) Yanyan Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coordinate expression and localization of iron and zinc transporters explain iron–zinc interactions during uptake in Caco-2 cells: implications for iron uptake at the enterocyte

(2011) Vasuprada Iyengar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo

(2011) Qiang Xu et al.   Journal of Zhejiang University-SCIENCE B

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

(2011) Carrie A Morris et al.   MALARIA JOURNAL

Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line

(2011) Jin-Jian Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin

(2011) Thomas Efferth et al.   PHYTOMEDICINE

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

(2010) Jin-Jian Lu et al.   CANCER BIOLOGY & THERAPY

p38 Mitogen-Activated Protein Kinase-Driven MAPKAPK2 Regulates Invasion of Bladder Cancer by Modulation of MMP-2 and MMP-9 Activity

(2010) B. Kumar et al.   CANCER RESEARCH

Arterolane, a New Synthetic Trioxolane for Treatment of UncomplicatedPlasmodium falciparumMalaria: A Phase II, Multicenter, Randomized, Dose‐Finding Clinical Trial

(2010) Neena Valecha et al.   CLINICAL INFECTIOUS DISEASES

Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells

(2010) Hao Chen et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties

(2010) Shahid Soomro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

Pharmacogenomic Identification of c-Myc/Max-Regulated Genes Associated with Cytotoxicity of Artesunate towards Human Colon, Ovarian and Lung Cancer Cell Lines

(2010) Serkan Sertel et al.   MOLECULES

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase

(2010) Qing-Ping Zeng et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells

(2010) Tan Weifeng et al.   PHYTOMEDICINE

Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expression

(2009) Hui-Jun Zhou et al.   ANTI-CANCER DRUGS

Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women

(2009) H. A. Karunajeewa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses

(2009) Shokoofe Noori et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-κB

(2009) Hua Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology

(2009) Zhenjun Hu et al.   NUCLEIC ACIDS RESEARCH

Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules

(2009) A Mielgo et al.   ONCOGENE

Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

(2009) Shiming Zhang et al.   PLoS One

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone

(2008) J. Nagelschmitz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

(2008) Shiming Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

(2008) Lin Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism

(2008) A. M. Giammarioli et al.   CANCER RESEARCH

Dihydroartemisinin Potentiates the Cytotoxic Effect of Temozolomide in Rat C6 Glioma Cells

(2008) Xiao-Jia Huang et al.   PHARMACOLOGY

Artemisinins: their growing importance in medicine

(2008) Sanjeev Krishna et al.   TRENDS IN PHARMACOLOGICAL SCIENCES