Transition‐Metal‐Mediated/Catalyzed Synthesis of Pyridines, Pyrimidines, and Triazines by [2+2+2] Cycloaddition Reactions

Regioselectivity in the Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of Unsymmetrical α,ω-Diynes with Nitrile: A DFT Study

(2020) Ken Sakata et al.   ORGANOMETALLICS

An Atom‐Economical Approach to 2‐Aryloxypyridines and 2,2′/2,3′‐Diaryloxybipyridines via Ruthenium‐Catalyzed [2+2+2] Cycloadditions

(2019) Pratibha Kalaramna et al.   ADVANCED SYNTHESIS & CATALYSIS

An Expeditious and Environmentally-Benign Approach to 2-Aryl/Heteroaryl Selenopyridines via Ruthenium Catalyzed [2+2+2] Cycloadditions

(2019) Pratibha Kalaramna et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Divergent Synthesis of Densely Substituted Arenes and Pyridines via Cyclotrimerization Reactions of Alkynyl Triazenes

(2019) Jin-Fay Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery

(2019) Nenad Manevski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium-Catalyzed, Microwave-Mediated [2+2+2] Cycloaddition: A Useful Combination for the Synthesis of 2-Aminopyridines

(2019) C. Tran et al.   SYNLETT

Synthesis of Multisubstituted Azatriphenylenes by Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of Biaryl-Linked Diynes with Nitriles

(2018) Ryo Takeuchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-aminopyridines via ruthenium-catalyzed [2+2+2] cycloaddition of 1,6- and 1,7-diynes with cyanamides: scope and limitations

(2018) Fei Ye et al.   NEW JOURNAL OF CHEMISTRY

Additive-Controlled Switchable Selectivity from Cyanobenzenes to 2-Alkynylpyridines: Ruthenium(II)-Catalyzed [2+2+2] Cycloadditions of Diynes and Alkynylnitriles

(2018) Divya Bhatt et al.   ADVANCED SYNTHESIS & CATALYSIS

Oxidative Coupling with Zr(IV) Supported by a Noninnocent Anthracene-Based Ligand: Application to the Catalytic Cotrimerization of Alkynes and Nitriles to Pyrimidines

(2018) Choon Heng Low et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Fluorescent Azafluorenones and Derivatives via a Ruthenium-Catalyzed [2 + 2 + 2] Cycloaddition

(2018) Fei Ye et al.   ORGANIC LETTERS

1,3,5-Triazines: A promising scaffold for anticancer drugs development

(2017) Stella Cascioferro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 2-Aminopyridine Derivatives from α,ω-Diynes and Cyanamides

(2017) Fei Ye et al.   ORGANIC LETTERS

FeCl3-Assisted Niobium-Catalyzed Cycloaddition of Nitriles and Alkynes: Synthesis of Alkyl- and Arylpyrimidines Based on Independent Functions of NbCl5 and FeCl3 Lewis Acids

(2017) Maito Fuji et al.   ORGANIC LETTERS

Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

(2016) Yu-Ling Chen et al.   CHEMICAL COMMUNICATIONS

Nickel-Catalyzed [2+2+2] Cycloaddition of Alkyne-Nitriles with Alkynes Assisted by Lewis Acids: Efficient Synthesis of Fused Pyridines

(2016) Xu You et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium-Catalyzed Synthesis of Acylpyridines by [2 + 2 + 2] Cycloaddition of Diynes with Acyl Cyanides

(2016) Toru Hashimoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Iron-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides

(2016) Nathan A. Spahn et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Naphthylpyridines from Unsymmetrical Naphthylheptadiynes and the Configurational Stability of the Biaryl Axis

(2016) Fabian Fischer et al.   JOURNAL OF ORGANIC CHEMISTRY

Theoretical study on Au(i)-catalyzed [2 + 2 + 2] cycloadditions of ynamides with two discrete nitriles

(2016) Haosheng Liang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of δ- and α-Carbolines via Nickel-Catalyzed [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles with Alkynes

(2016) Gaonan Wang et al.   ORGANIC LETTERS

Rhodium-Catalyzed Atroposelective [2 + 2 + 2] Cycloaddition of Ortho-Substituted Phenyl Diynes with Nitriles: Effect of Ortho Substituents on Regio- and Enantioselectivity

(2016) Kenichi Kashima et al.   ORGANIC LETTERS

Synthesis of Trifluoromethyl-Substituted Ethyl Picolinate Derivatives by the Cobalt-Catalyzed Regioselective Intermolecular [2+2+2] Cycloaddition

(2016) Motoi Kawatsura et al.   SYNLETT

Synthesis of Chiral Indenylcobalt(I) Complexes and Their Evaluation in Asymmetric [2+2+2] Cycloaddition Reactions

(2016) Marko Hapke et al.   SYNTHESIS-STUTTGART

Triazine as a promising scaffold for its versatile biological behavior

(2015) Prinka Singla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Niobium Complexes in Organic Transformations: From Stoichiometric Reactions to Catalytic [2+2+2] Cycloaddition Reactions

(2015) Yasushi Satoh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

3,5-Disubstituted 2-Aminopyridines via Nickel-Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides

(2015) Janis Louie et al.   SYNLETT

Regiocontrolled Gold-Catalyzed [2+2+2] Cycloadditions of Ynamides with Two Discrete Nitriles to Construct 4-Aminopyrimidine Cores

(2014) Somnath Narayan Karad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions

(2014) V. A. Rassadin et al.   CHEMICAL COMMUNICATIONS

Nickel-Catalyzed Synthesis ofN-Aryl-1,2-dihydropyridines by [2+2+2] Cycloaddition of Imines with Alkynes through T-Shaped 14-Electron Aza-Nickelacycle Key Intermediates

(2014) Yoichi Hoshimoto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Stereoselective [2+2+2] Cycloadditions

(2014) Muriel Amatore et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Synthesis of 1,3,5-Triazine Derivatives via Controlled Cross-Cyclotrimerization of Nitriles: A Mechanism Approach

(2014) Antonio Herrera et al.   JOURNAL OF ORGANIC CHEMISTRY

Computational insight into Wilkinson's complex catalyzed [2 + 2 + 2] cycloaddition mechanism leading to pyridine formation

(2014) Òscar Torres et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Copper(II)-Catalyzed Three-Component Cascade Annulation of Diaryliodoniums, Nitriles, and Alkynes: A Regioselective Synthesis of Multiply Substituted Quinolines

(2013) Yong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Air-Stable and Recyclable CpCoI-Complexes

(2013) Indre Thiel et al.   ChemCatChem

One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles

(2013) Xiang Su et al.   CHEMICAL COMMUNICATIONS

The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides

(2013) Timothy K. Lane et al.   CHEMICAL COMMUNICATIONS

Iron(ii)-catalysed [2+2+2] cycloaddition for pyridine ring construction

(2013) Vincent Richard et al.   CHEMICAL COMMUNICATIONS

Iron-Catalyzed Cycloaddition Reaction of Diynes and Cyanamides at Room Temperature

(2013) Chunxiang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Low-Valent Niobium-Catalyzed Intermolecular [2 + 2 + 2] Cycloaddition of tert-Butylacetylene and Arylnitriles to Form 2,3,6-Trisubstituted Pyridine Derivatives

(2013) Yasushi Satoh et al.   JOURNAL OF ORGANIC CHEMISTRY

Syntheses of (+)-Complanadine A and Lycodine Derivatives by Regioselective [2 + 2 + 2] Cycloadditions

(2013) Changxia Yuan et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Rhodium-Catalyzed [2+2+2] Cycloaddition of Diynes to Sulfonimines

(2013) Muriel Amatore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Evaluation of the Ni(IPr)2-Catalyzed Cycloaddition of Alkynes and Nitriles To Afford Pyridines: Evidence for the Formation of a Key η1-Ni(IPr)2(RCN) Intermediate

(2013) Ryan M. Stolley et al.   ORGANOMETALLICS

Reactions of Zirconocene Butadiyne or Monoyne Complexes with Nitriles: Straightfoward Synthesis of Functionalized Pyrimidines

(2013) Xu You et al.   ORGANOMETALLICS

Rhodium-Catalyzed [2+2+2] Cycloaddition of Oximes and Diynes To Give Pyridines

(2012) Fen Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fine-Tuning the Reactivity and Stability by Systematic Ligand Variations in CpCoIComplexes as Catalysts for [2+2+2] Cycloaddition Reactions

(2012) Indre Thiel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Aminopyridines and Aminopyridones by Cobalt-Catalyzed [2+2+2] Cycloadditions Involving Yne-Ynamides: Scope, Limitations, and Mechanistic Insights

(2012) Pierre Garcia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium-Catalyzed [2+2+2] Cycloaddition for the Synthesis of Substituted Pyridines, Pyridones, and Thiopyranimines

(2012) Ken Tanaka   HETEROCYCLES

Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Nitriles

(2012) Gen Onodera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Generation of Pyridines by Ruthenium Carbene Mediated [2 + 2 + 2] Cyclotrimerization

(2012) Sandra Medina et al.   ORGANIC LETTERS

Strategy for the Synthesis of Pyrimidine Derivatives: NbCl5-Mediated Cycloaddition of Alkynes and Nitriles

(2012) Yasushi Satoh et al.   ORGANOMETALLICS

A Simple and Highly Efficient Iron Catalyst for a [2+2+2] Cycloaddition to Form Pyridines

(2011) Chunxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in [2+2+2] cycloaddition reactions

(2011) Gema Domínguez et al.   CHEMICAL SOCIETY REVIEWS

New symmetrically substituted 1,3,5-triazines as host compounds for channel-type inclusion formation

(2011) Ricarda Berger et al.   CRYSTENGCOMM

Nickel-Catalyzed [2+2+2] Cycloaddition of Diynes and Cyanamides

(2011) Ryan M. Stolley et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of the Pyridine Core of Cyclothiazomycin

(2011) Yan Zou et al.   ORGANIC LETTERS

Iron-Catalyzed Cycloaddition of Alkynenitriles and Alkynes

(2011) Brendan R. D’Souza et al.   ORGANIC LETTERS

Regioselective Syntheses of Substituted Pyridines and 2,2′-Bipyridines by Cobalt-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Nitriles

(2011) Sentaro Okamoto et al.   SYNTHESIS-STUTTGART

Catalytic Cyclotrimerization of Arylnitriles Using the Novel Samarium (II) Complexes as Catalysts

(2010) Fan Xu et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of (+)-Complanadine A, an Inducer of Neurotrophic Factor Excretion

(2010) Changxia Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization−Coupled Intramolecular Nucleophilic Substitution Reaction

(2010) Andrew L. McIver et al.   ORGANIC LETTERS

New Strategies for the Synthesis of Pyrimidine Derivatives

(2008) Matthew D. Hill et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in the Synthesis of Pyridines by Transition-Metal-Catalyzed [2+2+2] Cycloaddition

(2008) Carlos Saá et al.   SYNLETT