4.4 Article

Recent Advances in the Synthesis of Pyridines by Transition-Metal-Catalyzed [2+2+2] Cycloaddition

Journal

SYNLETT
Volume -, Issue 17, Pages 2571-2578

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1078275

Keywords

alkynes; cycloadditions; transition-metal catalysis; nitriles; pyridines

Funding

  1. Ministerio de Educacion y Ciencia (Spain)
  2. European Regional Development [CTQ2005-08613, CSD2007-00006]
  3. Xunta de Galicia [2007/XA084, PGIDIT06PXIC209041 PN]

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Pyridines can be efficiently synthesized by the transition-metal-catalyzed [2+2+2] cycloaddition reactions between two alkynes and one nitrile. In this account, we present the state of the art in this area with particular emphasis on the metal catalyst utilized in the reaction.

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