System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Falcipain cysteine proteases of malaria parasites: An update

(2020) Philip J. Rosenthal   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance

(2018) Souvik Bhattacharjee et al.   BLOOD

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

(2017) Fabian Baumgärtner et al.   MALARIA JOURNAL

Cellular mechanisms of action and resistance of Plasmodium falciparum to artemisinin

(2017) Papichaya Phompradit et al.   PARASITOLOGY RESEARCH

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

(2016) Tuo Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype

(2016) A. Siriwardana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

(2016) Erik L. Allman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

(2016) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of OZ439 (artefenomel) against earlyPlasmodium falciparumblood-stage malaria infection in healthy volunteers

(2016) James S. McCarthy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

(2016) Aung Pyae Phyo et al.   LANCET INFECTIOUS DISEASES

Plasmodium falciparum: multifaceted resistance to artemisinins

(2016) Lucie Paloque et al.   MALARIA JOURNAL

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artemisinin Action and Resistance in Plasmodium falciparum

(2016) Leann Tilley et al.   TRENDS IN PARASITOLOGY

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

(2016) Lucía Serrán-Aguilera et al.   Scientific Reports

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum

(2015) Sonia Gulati et al.   Cell Host & Microbe

Haemoglobin degradation underpins the sensitivity of early ring stagePlasmodium falciparumto artemisinins

(2015) Stanley C. Xie et al.   JOURNAL OF CELL SCIENCE

Metabolic Dysregulation Induced inPlasmodium falciparumby Dihydroartemisinin and Other Front-Line Antimalarial Drugs

(2015) Simon A. Cobbold et al.   JOURNAL OF INFECTIOUS DISEASES

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Current peptidomics: Applications, purification, identification, quantification, and functional analysis

(2015) David C. Dallas et al.   PROTEOMICS

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

(2015) Joëlle Jourdan et al.   ACS Infectious Diseases

Activity-Based Profiling of Proteases

(2014) Laura E. Sanman et al.   Annual Review of Biochemistry

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins

(2014) Stanley C. Xie et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Access to artemisinin-based combination therapy (ACT) and quinine in malaria holoendemic regions of western Kenya

(2014) Carren A Watsierah et al.   MALARIA JOURNAL

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Working in concert: the metalloaminopeptidases from Plasmodium falciparum

(2013) Sheena McGowan   CURRENT OPINION IN STRUCTURAL BIOLOGY

Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects

(2013) Nilanjan Saha et al.   JOURNAL OF CLINICAL PHARMACOLOGY

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

(2012) Joerg J. Moehrle et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Arterolane Maleate Plus Piperaquine Phosphate for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Comparative, Multicenter, Randomized Clinical Trial

(2012) N. Valecha et al.   CLINICAL INFECTIOUS DISEASES

The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?

(2012) Makoah Nigel Aminake et al.   International Journal for Parasitology-Drugs and Drug Resistance

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

Unraveling the Ubiquitome of the Human Malaria Parasite

(2011) Nadia Ponts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes

(2011) Carmony L. Hartwig et al.   JOURNAL OF MEDICINAL CHEMISTRY

PEAKS DB:De NovoSequencing Assisted Database Search for Sensitive and Accurate Peptide Identification

(2011) Jing Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Neutral Lipid Composition Present in the Digestive Vacuole ofPlasmodium falciparumConcentrates Heme and Mediates β-Hematin Formation with an Unusually Low Activation Energy

(2010) Anh N. Hoang et al.   BIOCHEMISTRY

Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes

(2010) Edgar Deu et al.   CHEMISTRY & BIOLOGY

Evaluation and optimization of removal of an acid-insoluble surfactant for shotgun analysis of membrane proteome

(2010) Yong Lin et al.   ELECTROPHORESIS

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

(2010) N. A. Bakar et al.   JOURNAL OF CELL SCIENCE

Pharmacokinetics and Pharmacodynamics of Arterolane Maleate Following Multiple Oral Doses in Adult Patients WithP. falciparumMalaria

(2010) Anirudh Gautam et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Malaria's Drug Miracle in Danger

(2010) M. Enserink   SCIENCE

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

(2008) Lin Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY