Progress and challenges in the discovery of macrofilaricidal drugs

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs

(2011) Charles D Mackenzie et al.   Expert Review of Anti-Infective Therapy

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

(2011) PR Little et al.   NEW ZEALAND VETERINARY JOURNAL

Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype

(2011) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

(2010) P. A. Spagnuolo et al.   BLOOD

Elimination of lymphatic filariasis: do we have the drugs to complete the job?

(2010) Moses J Bockarie et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Towards novel antifilarial drugs: challenges and recent developments

(2010) Prashant Kumar Singh et al.   Future Medicinal Chemistry

Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans

(2010) Elizabeth Ruiz-Lancheros et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats

(2010) Jian Xue et al.   PARASITOLOGY RESEARCH

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

(2010) Y. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis)

(2010) G. Grandi et al.   VETERINARY PARASITOLOGY

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial

(2010) Joseph D. Turner et al.   PLoS Neglected Tropical Diseases

Evaluation of Oxfendazole, Praziquantel and Albendazole against Cystic Echinococcosis: A Randomized Clinical Trial in Naturally Infected Sheep

(2010) Cesar M. Gavidia et al.   PLoS Neglected Tropical Diseases

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

(2010) Gregory J. Crowther et al.   PLoS Neglected Tropical Diseases

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect

(2010) Lucien Rufener et al.   PLoS Pathogens

Unresolved issues in anthelmintic pharmacology for helminthiases of humans

(2009) Timothy G. Geary et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon

(2009) Samuel Wanji et al.   Parasites & Vectors

Flubendazole in cystic echinococcosis therapy: Pharmaco-parasitological evaluation in mice

(2009) Laura Ceballos et al.   PARASITOLOGY INTERNATIONAL

A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

(2009) Barry C. Hosking et al.   PARASITOLOGY RESEARCH

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

(2009) T. S. Churcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heartworm Biology, Treatment, and Control

(2009) Dwight D. Bowman et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist

(2009) Yan Hu et al.   PLoS Neglected Tropical Diseases

Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling

(2009) Sasisekhar Bennuru et al.   PLoS Neglected Tropical Diseases

Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

(2009) Solomon Nwaka et al.   PLoS Neglected Tropical Diseases

The Mectizan Donation Program (MDP)

(2008) B. Thylefors   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Doxycycline Treatment ofBrugia malayi–Infected Persons Reduces Microfilaremia and Adverse Reactions after Diethylcarbamazine and Albendazole Treatment

(2008) Taniawati Supali et al.   CLINICAL INFECTIOUS DISEASES

Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis

(2008) Achim Hoerauf   CURRENT OPINION IN INFECTIOUS DISEASES

Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes

(2008) Ramakrishna U. Rao et al.   EXPERIMENTAL PARASITOLOGY

Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs

(2008) C. Bazzocchi et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus

(2008) Catherine Bourguinat et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The secretome of the filarial parasite, Brugia malayi: Proteomic profile of adult excretory–secretory products

(2008) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A new class of anthelmintics effective against drug-resistant nematodes

(2008) Ronald Kaminsky et al.   NATURE

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle

(2008) Barend M deC Bronsvoort et al.   Parasites & Vectors

Heartworm and Wolbachia: Therapeutic implications

(2008) J.W. McCall et al.   VETERINARY PARASITOLOGY

The Global Programme to Eliminate Lymphatic Filariasis: Health Impact after 8 Years

(2008) Eric A. Ottesen et al.   PLoS Neglected Tropical Diseases

Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness

(2008) Judith E. Allen et al.   PLoS Neglected Tropical Diseases

Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

(2008) Yovany Moreno et al.   PLoS Neglected Tropical Diseases