Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

Evaluation of in vitro culture systems for the maintenance of microfilariae and infective larvae of Loa loa

(2018) Denis Zofou et al.   Parasites & Vectors

Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models

(2018) Amy E. Marriott et al.   Scientific Reports

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model

(2018) Sabine Specht et al.   PLoS Neglected Tropical Diseases

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

(2018) Joseph D. Turner et al.   PLoS Pathogens

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachiacurative treatments in preclinical models of filariasis

(2017) Joseph D. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

(2017) Ute Klarmann-Schulz et al.   PLoS Neglected Tropical Diseases

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

(2017) Ghaith Aljayyoussi et al.   Scientific Reports

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

(2016) Raman Sharma et al.   Scientific Reports

Neglected tropical diseases in Africa: a new paradigm

(2016) Adrian D. Hopkins   International Health

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

(2016) Jesuthas Ajendra et al.   Scientific Reports

Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic Loiasis (Loa loa) in the Baboon (Papio anubis)

(2015) Samuel Wanji et al.   PLoS Neglected Tropical Diseases

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

(2014) Martin Walker et al.   CLINICAL INFECTIOUS DISEASES

Multidimensional complexities of filariasis control in an era of large-scale mass drug administration programmes: a can of worms

(2014) David H Molyneux et al.   Parasites & Vectors

A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis

(2014) Alice Halliday et al.   Parasites & Vectors

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

(2014) Kelly L. Johnston et al.   International Journal for Parasitology-Drugs and Drug Resistance

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

(2013) MARK J. TAYLOR et al.   PARASITOLOGY

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

(2012) Andrea Schiefer et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis

(2012) Sebastian Ziewer et al.   PLoS Neglected Tropical Diseases

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

The Wolbachia endosymbiont as an anti-filarial nematode target

(2010) Barton E. Slatko et al.   SYMBIOSIS

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial

(2010) Joseph D. Turner et al.   PLoS Neglected Tropical Diseases