Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits

(2020) Shaza B. Zaghlool et al.   Nature Communications

Bayesian reassessment of the epigenetic architecture of complex traits

(2020) Daniel Trejo Banos et al.   Nature Communications

Inflammatory biomarkers in Alzheimer's disease plasma

(2019) Angharad R. Morgan et al.   Alzheimers & Dementia

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

(2019) Robert F. Hillary et al.   Nature Communications

IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions

(2019) Michelle A. Williams et al.   Frontiers in Immunology

Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers

(2019) Julia Höglund et al.   Scientific Reports

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

AHRR hypomethylation, lung function, lung function decline and respiratory symptoms

(2018) Jakob B. Kodal et al.   EUROPEAN RESPIRATORY JOURNAL

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly

(2018) Chris P. Verschoor et al.   EXPERIMENTAL GERONTOLOGY

Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936

(2018) Adele M Taylor et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

(2018) Stefan Enroth et al.   Scientific Reports

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance

(2018) Yuchao Ren et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

(2018) Chen Yao et al.   Nature Communications

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

(2018) Symen Ligthart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Critical Role of CD6highCD4+ T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD

(2018) Caiyun Ma et al.   Journal of Crohns & Colitis

Peripheral immune system in aging and Alzheimer’s disease

(2018) Wei Cao et al.   Molecular Neurodegeneration

Estimation of a significance threshold for epigenome-wide association studies

(2017) Ayden Saffari et al.   GENETIC EPIDEMIOLOGY

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases

(2017) Muhammad Ahsan et al.   PLoS Genetics

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors

(2017) Antonio F. Di Narzo et al.   PLoS Genetics

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Comparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer-related genes in prediction of lung cancer mortality

(2016) Yan Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Disease variants alter transcription factor levels and methylation of their binding sites

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies

(2016) Elior Rahmani et al.   NATURE METHODS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

(2016) Carola Marzi et al.   PLoS One

Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies

(2016) Seung Hoan Choi et al.   PLoS Genetics

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

(2016) Wei Sun et al.   PLoS Genetics

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

(2016) Yuetiva Deming et al.   Scientific Reports

Plasma Levels of Soluble Interleukin-2 Receptor αSignificance

(2015) Peter Durda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

(2015) Paul S. de Vries et al.   HUMAN MOLECULAR GENETICS

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

(2015) H. Guo et al.   HUMAN MOLECULAR GENETICS

An epigenome-wide association study of total serum immunoglobulin E concentration

(2015) Liming Liang et al.   NATURE

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2

(2014) Jie Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reference-free cell mixture adjustments in analysis of DNA methylation data

(2014) Eugene Andres Houseman et al.   BIOINFORMATICS

The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women

(2014) Meeshanthini V Dogan et al.   BMC GENOMICS

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

(2014) Loukia G Tsaprouni et al.   Epigenetics

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels

(2014) Johnny S.H. Kwan et al.   HUMAN MOLECULAR GENETICS

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L

(2014) Alexander Viktorin et al.   HUMAN MOLECULAR GENETICS

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

(2014) Jennifer E. Ho et al.   JOURNAL OF CLINICAL INVESTIGATION

Cigarette Smoking and Variations in Systemic Immune and Inflammation Markers

(2014) Meredith S. Shiels et al.   JNCI-Journal of the National Cancer Institute

Epigenome-wide association studies without the need for cell-type composition

(2014) James Zou et al.   NATURE METHODS

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Differences in smoking associated DNA methylation patterns in South Asians and Europeans

(2014) Hannah R Elliott et al.   Clinical Epigenetics

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults

(2013) A.M. Matteini et al.   CYTOKINE

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

The advantages and limitations of trait analysis with GWAS: a review

(2013) Arthur Korte et al.   Plant Methods

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

Gene-Specific DNA Methylation Association with Serum Levels of C-Reactive Protein in African Americans

(2013) Yan V. Sun et al.   PLoS One

Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers

(2013) Emilio Fernandez-Egea et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

(2012) J. Huang et al.   BLOOD

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children

(2012) V. Saroja Voruganti et al.   CYTOKINE

Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers

(2012) Robert A. Philibert et al.   Epigenetics

Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population

(2012) M Liao et al.   GENES AND IMMUNITY

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

(2012) Albert M. Levin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A mixed-model approach for genome-wide association studies of correlated traits in structured populations

(2012) Arthur Korte et al.   NATURE GENETICS

Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population

(2012) Ming Yang et al.   PLoS One

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

(2012) L. B. Barreiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects

(2012) Xiaobo Yang et al.   PLoS Genetics

A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

(2012) Silvia Naitza et al.   PLoS Genetics

Using control genes to correct for unwanted variation in microarray data

(2011) J. A. Gagnon-Bartsch et al.   BIOSTATISTICS

Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

(2011) Nicholas L. Smith et al.   CIRCULATION

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans

(2011) Fasil Tekola Ayele et al.   IMMUNOGENETICS

Genome-Wide Association Study Identifies Variants at the IL18 -BCO2 Locus Associated With Interleukin-18 Levels

(2010) Meian He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Genotype Imputation

(2009) Yun Li et al.   Annual Review of Genomics and Human Genetics

Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

(2009) R. B. Schnabel et al.   BLOOD

Smoking Affects Eotaxin Levels in Asthma Patients

(2009) Algirda Krisiukeniene et al.   JOURNAL OF ASTHMA

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY