Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion

Dl-3-n-Butylphthalide regulates the Ang-1/Ang-2/Tie-2 signaling axis to promote neovascularization in chronic cerebral hypoperfusion

(2019) Wenxian Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis

(2019) Wenxian Li et al.   Frontiers in Cellular Neuroscience

Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice

(2019) Xianjun Chen et al.   Neuroscience Bulletin

Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis

(2019) Fariba Houshmand et al.   DARU-Journal of Pharmaceutical Sciences

White matter degeneration in vascular and other ageing-related dementias

(2018) Yoshiki Hase et al.   JOURNAL OF NEUROCHEMISTRY

DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats

(2018) Qianqian Qi et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation

(2018) Eman M. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protective Role of S-Nitrosoglutathione (GSNO) Against Cognitive Impairment in Rat Model of Chronic Cerebral Hypoperfusion

(2018) Je-Seong Won et al.   JOURNAL OF ALZHEIMERS DISEASE

Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation

(2018) Claire Lyons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease

(2018) Maja Dembic et al.   MOLECULAR GENETICS AND METABOLISM

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

l-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia–Reperfusion Injury

(2017) Jing Xu et al.   NEUROCHEMICAL RESEARCH

Physical Exercise Improves Cognitive Function Together with Microglia Phenotype Modulation and Remyelination in Chronic Cerebral Hypoperfusion

(2017) Ting Jiang et al.   Frontiers in Cellular Neuroscience

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion

(2017) Zhilin Xiong et al.   Frontiers in Aging Neuroscience

Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis

(2016) Osamu Imamura et al.   JOURNAL OF NEUROCHEMISTRY

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

(2016) Claudia Pösel et al.   Jove-Journal of Visualized Experiments

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

Demyelination as a rational therapeutic target for ischemic or traumatic brain injury

(2015) Hong Shi et al.   EXPERIMENTAL NEUROLOGY

Vascular dementia

(2015) John T O'Brien et al.   LANCET

STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis

(2015) Yanyong Sun et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Ecto-5′-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines

(2015) X. Hou et al.   NEUROSCIENCE

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination

(2015) Amélie Wegener et al.   BRAIN

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

(2014) Daniel Kaiser et al.   Acta Neuropathologica Communications

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Sterile Inflammation after Permanent Distal MCA Occlusion in Hypertensive Rats

(2013) Karoline Möller et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Activation of SIRT1: Role in Neuropathology

(2013) Alanna Fernandes Paraíso et al.   MOLECULAR NEUROBIOLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Inhibition of NADPH Oxidase Activation in Oligodendrocytes Reduces Cytotoxicity Following Trauma

(2013) Joshua T. Johnstone et al.   PLoS One

Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1

(2012) Hidetaka Ota et al.   PLoS One

White matter lesions defined by diffusion tensor imaging in older adults

(2011) Stephen A. Back et al.   ANNALS OF NEUROLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: An ongoing story

(2011) Ana Caminero et al.   JOURNAL OF NEUROIMMUNOLOGY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells

(2010) Fang Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

(2010) A. A. Gouw et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

(2009) Biplab Dasgupta et al.   DEVELOPMENTAL CELL

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Overexpression of SIRT1 Protects Pancreatic  -Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor- B Signaling Pathway

(2008) J.-H. Lee et al.   DIABETES

The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe Disease

(2008) Shailendra Giri et al.   JOURNAL OF NEUROCHEMISTRY

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE