7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

7-Ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox4 and Atg4B

(2013) Chaoyong He et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase

(2013) Avinash Appukuttan et al.   CARDIOVASCULAR RESEARCH

Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils

(2013) María E. Reyes-Quiroz et al.   FEBS Journal

Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF- B

(2012) I. L. M. H. Aye et al.   MOLECULAR HUMAN REPRODUCTION

Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils

(2012) Gonzalo Alba et al.   PLoS One

Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol

(2010) B. Dugas et al.   EUROPEAN JOURNAL OF NUTRITION

Oxysterols: A world to explore

(2010) A. Otaegui-Arrazola et al.   FOOD AND CHEMICAL TOXICOLOGY

Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate

(2010) Cinzia Mascia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression

(2010) Paola Palozza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells

(2010) Gabriella Leonarduzzi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: A potential mechanism of inflammatory bowel disease progression

(2009) Fiorella Biasi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cholesterol oxidation products in the vascular remodeling due to atherosclerosis

(2009) Giuseppe Poli et al.   MOLECULAR ASPECTS OF MEDICINE

Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils

(2008) Gonzalo Alba et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oxysterols: Novel biologic roles for the 21st century

(2007) Norman B. Javitt   STEROIDS

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

(2007) Wei-Jiunn Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY