Mitochondria in skin health, aging, and disease

Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

(2019) Fabio Marcheggiani et al.   Aging-US

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions

(2018) Russel Reiter et al.   MOLECULES

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

(2018) Bhupendra Singh et al.   Cell Death & Disease

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

(2018) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fragmentation of the mitochondrial network in skin in vivo

(2017) Daniel Mellem et al.   PLoS One

Melatonin-loaded chitosan/Pluronic® F127 microspheres as in situ forming hydrogel: An innovative antimicrobial wound dressing

(2016) Marieta Duvnjak Romić et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Age-Dependent Decrease of Mitochondrial Complex II Activity in Human Skin Fibroblasts

(2016) Amy Bowman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondrial DNA deletion percentage in sun exposed and non sun exposed skin

(2016) Julia M. Powers et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10

(2016) Daniel Schniertshauer et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes

(2016) Romain Jugé et al.   Scientific Reports

Altered mitochondrial DNA copy number contributes to human cancer risk: evidence from an updated meta-analysis

(2016) Liwen Hu et al.   Scientific Reports

Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects

(2015) Anja Knott et al.   BIOFACTORS

Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR

(2015) Aparna Bhaduri et al.   DEVELOPMENTAL CELL

The Peripheral Clock Regulates Human Pigmentation

(2015) Jonathan A. Hardman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Natural and Sun-Induced Aging of Human Skin

(2015) L. Rittie et al.   Cold Spring Harbor Perspectives in Medicine

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

(2015) Arnaldur Hall et al.   Oncotarget

Mitochondrial dysfunction: a neglected component of skin diseases

(2014) René G. Feichtinger et al.   EXPERIMENTAL DERMATOLOGY

Single nucleotide polymorphisms in the mitochondrial displacement loop region modifies malignant melanoma: a study in Chinese Han population

(2014) Wenjin Zhang et al.   Mitochondrial DNA

Manganese Superoxide Dismutase in Cancer Prevention

(2013) Delira Robbins et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A

(2013) Silvia Ravera et al.   BIOCHIMIE

Clinical and magnetic resonance imaging findings in patients with Leigh syndrome and SURF1 mutations

(2013) Kothari Sonam et al.   BRAIN & DEVELOPMENT

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia

(2013) Nilesh K. Sharma et al.   DNA REPAIR

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

(2013) Tae-Kang Kim et al.   FASEB JOURNAL

Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide

(2013) Anne O. Oyewole et al.   FASEB JOURNAL

UV Radiation and the Skin

(2013) John D'Orazio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

(2013) Mina Kalantari-Dehaghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58

(2013) Kathrin A. Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

(2013) José Rivera-Torres et al.   Journal of Proteomics

Mitochondrial deficiency in Cockayne syndrome

(2013) Morten Scheibye-Knudsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Heme a Synthase Cox15 Associates with Cytochrome c Oxidase Assembly Intermediates during Cox1 Maturation

(2013) B. Bareth et al.   MOLECULAR AND CELLULAR BIOLOGY

Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: Clues for the pathogenesis in the human inherited disorder

(2013) A. Hernández-Vázquez et al.   MOLECULAR GENETICS AND METABOLISM

Genotype–phenotype spectrum of PYCR1-related autosomal recessive cutis laxa

(2013) Aikaterini Dimopoulou et al.   MOLECULAR GENETICS AND METABOLISM

Samhd1 knockout mice: modeling retrovirus restriction in vivo

(2013) Li Wu   Retrovirology

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Mitochondrial respiratory complex I defects in Fanconi anemia

(2013) Enrico Cappelli et al.   TRENDS IN MOLECULAR MEDICINE

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

(2012) Deborah L. Croteau et al.   AGING CELL

Mutations in COX7B Cause Microphthalmia with Linear Skin Lesions, an Unconventional Mitochondrial Disease

(2012) Alessia Indrieri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A new role for ATM

(2012) Yasmine A. Valentin-Vega et al.   Autophagy

Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism

(2012) M. Ibarrola-Villava et al.   BRITISH JOURNAL OF DERMATOLOGY

The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity

(2012) Adam Labbé et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial common deletion mutation and extrinsic skin ageing in German and Japanese women

(2012) Natsumi Kaneko et al.   EXPERIMENTAL DERMATOLOGY

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endemic Pemphigus Foliaceus: Towards Understanding Autoimmune Mechanisms of Disease Development

(2012) Giovanni Di Zenzo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melatonin prevents ultraviolet radiation-induced alterations in plasma membrane potential and intracellular pH in human keratinocytes

(2012) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

(2012) Tobias W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A High-Throughput Panel for Identifying Clinically Relevant Mutation Profiles in Melanoma

(2012) K. Dutton-Regester et al.   MOLECULAR CANCER THERAPEUTICS

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatocerebral form of mitochondrial DNA depletion syndrome due to mutation in MPV17 gene

(2012) Abdulaziz AlSaman et al.   Saudi Journal of Gastroenterology

BCS1L gene mutation presenting with GRACILE-like syndrome and complex III deficiency

(2012) A. M. Lynn et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Biochemical rationale and experimental data on the antiaging properties of CoQ10 at skin level

(2011) Thomas Blatt et al.   BIOFACTORS

Mitochondrial Protection by Resveratrol

(2011) Zoltan Ungvari et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Genetics of Dupuytren's disease

(2011) Laëtitia Michou et al.   JOINT BONE SPINE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2

(2011) M Fernanda Amary et al.   NATURE GENETICS

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

(2011) Nilesh K. Sharma et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Haplogroups, Control Region Polymorphisms and Malignant Melanoma: A Study in Middle European Caucasians

(2011) Sabine Ebner et al.   PLoS One

Coenzyme Q – Biosynthesis and functions

(2010) Magnus Bentinger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome

(2010) Federico V. Pallardó et al.   BIOGERONTOLOGY

Congenital myasthenic syndrome associated with epidermolysis bullosa caused by homozygous mutations in PLEC1 and CHRNE

(2010) RA Maselli et al.   CLINICAL GENETICS

Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndrome

(2010) KJ Champion et al.   CLINICAL GENETICS

Mitochondrial dysfunction and organic aciduria in five patients carrying mutations in the Ras-MAPK pathway

(2010) Tjitske Kleefstra et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Autophagy in human keratinocytes: an early step of the differentiation?

(2010) Elodie Aymard et al.   EXPERIMENTAL DERMATOLOGY

Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts

(2009) Marc Majora et al.   AMERICAN JOURNAL OF PATHOLOGY

Aging skin is functionally anaerobic: Importance of coenzyme Q10for anti aging skin care

(2009) S. Prahl et al.   BIOFACTORS

Discovery of Genes Essential for Heme Biosynthesis through Large-Scale Gene Expression Analysis

(2009) Roland Nilsson et al.   Cell Metabolism

Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model

(2009) Jean Krutmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Mutations in PYCR1 cause cutis laxa with progeroid features

(2009) Bruno Reversade et al.   NATURE GENETICS

The causes of mutation accumulation in mitochondrial genomes

(2009) M. Neiman et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus

(2009) Juan Du et al.   ARTHRITIS RESEARCH & THERAPY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Phenotypic Variants of the Deafness-Associated Mitochondrial DNA A7445G Mutation

(2008) Anita Maasz et al.   CURRENT MEDICINAL CHEMISTRY

Partial Depletion of Mitochondrial DNA from Human Skin Fibroblasts Induces a Gene Expression Profile Reminiscent of Photoaged Skin

(2008) Peter Schroeder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas

(2008) Suhail K. Mithani et al.   MELANOMA RESEARCH