Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2

Targetable Gene Fusions Identified in Radioactive Iodine-Refractory Advanced Thyroid Carcinoma

(2019) Karin van der Tuin et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells

(2019) Lu Wan et al.   FASEB JOURNAL

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells

(2018) Zhifen Zhou et al.   CANCER RESEARCH

AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis

(2018) Bin Zheng et al.   CELLULAR SIGNALLING

Aggressive differentiated thyroid cancer

(2018) Noor Janjua et al.   EJSO

PKM2, a potential target for regulating cancer

(2018) Yu-huan Li et al.   GENE

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

(2018) Xiaoping Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

(2018) Binbin Wang et al.   JOURNAL OF HEADACHE AND PAIN

Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway

(2018) Jian-cai Tang et al.   LIFE SCIENCES

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

(2018) Lijun Jia et al.   LIFE SCIENCES

MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma

(2018) AGNIESZKA ZEMBSKA et al.   ANTICANCER RESEARCH

Insilico structure modeling and molecular docking analysis of phosphoribosyl pyrophosphate amidotransferase (PPAT) with antifolate inhibitors

(2018) Nousheen Bibi et al.   CURRENT CANCER DRUG TARGETS

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells

(2017) Chang-Ying Guo et al.   ONCOLOGY REPORTS

Exploring targeted therapy of osteosarcoma using proteomics data

(2017) Parunya Chaiyawat et al.   OncoTargets and Therapy

A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

(2017) Ying Zhu et al.   mBio

Radiation exposure and thyroid cancer: a review

(2017) Maria Laura Iglesias et al.   Archives of Endocrinology Metabolism

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer

(2016) Wei Lu et al.   Scientific Reports

PKM2 contributes to cancer metabolism

(2015) Nicholas Wong et al.   CANCER LETTERS

PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

(2015) Zheng Zhao et al.   TUMOR BIOLOGY

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

(2015) Moloy T. Goswami et al.   Oncotarget

Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease

(2014) Milojkovic Boban et al.   RENAL FAILURE

Fuzzy optimization for detecting enzyme targets of human uric acid metabolism

(2013) Kai-Cheng Hsu et al.   BIOINFORMATICS

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and theBRAFMutation in Papillary Thyroid Cancer

(2013) Chen Feng et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

(2012) Chunmei Wang et al.   JOURNAL OF HEPATOLOGY

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE