The Role of the Human Cytomegalovirus UL133-UL138 Gene Locus in Latency and Reactivation

A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein

(2020) Yang Li et al.   MOLECULES

Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos

(2019) Benjamin A. Krishna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis

(2019) Mohamed Zuhair et al.   REVIEWS IN MEDICAL VIROLOGY

The IκB kinases restrict human cytomegalovirus infection

(2019) Christopher M. Goodwin et al.   JOURNAL OF VIROLOGY

Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter

(2019) Liane Dupont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative promoters drive human cytomegalovirus reactivation from latency

(2019) Donna Collins-McMillen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Golgi sorting motifs of human cytomegalovirus UL138 are not required for latency maintenance

(2019) Christopher B. Gelbmann et al.   VIRUS RESEARCH

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34+ Hematopoietic Progenitor Cells and Humanized NSG Mice

(2019) Lindsey B. Crawford et al.   mBio

A novel murine model of differentiation-mediated cytomegalovirus reactivation from latently infected bone marrow haematopoietic cells

(2019) Xue-feng Liu et al.   JOURNAL OF GENERAL VIROLOGY

Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency

(2019) Jason Buehler et al.   PLoS Pathogens

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

(2019) Iliyana Mikell et al.   PLoS Pathogens

Human Cytomegalovirus miRNAs Regulate TGF-β to Mediate Myelosuppression while Maintaining Viral Latency in CD34+ Hematopoietic Progenitor Cells

(2019) Meaghan H. Hancock et al.   Cell Host & Microbe

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

(2018) Miri Shnayder et al.   mBio

Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation

(2018) Lindsey B. Crawford et al.   mBio

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency

(2018) Michael A. Rak et al.   JOURNAL OF VIROLOGY

The Human Cytomegalovirus, from Oncomodulation to Oncogenesis

(2018) Georges Herbein   Viruses-Basel

There Is Always Another Way! Cytomegalovirus’ Multifaceted Dissemination Schemes

(2018) Joseph Jackson et al.   Viruses-Basel

Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency

(2018) Eleonora Forte et al.   mBio

ERK signalling as a regulator of cell motility

(2017) Susumu Tanimura et al.   JOURNAL OF BIOCHEMISTRY

Transcriptional regulation and influence on replication of the human cytomegalovirus UL138 1.4 kb transcript

(2017) Liying Han et al.   Molecular Medicine Reports

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency

(2017) Shu Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection

(2017) Benjamin A. Krishna et al.   mBio

Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes

(2016) Megan A. Peppenelli et al.   JOURNAL OF VIROLOGY

Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency

(2016) Song Hee Lee et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes

(2016) Olesea Cojohari et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34 + Human Progenitor Cells

(2016) Jung Heon Kim et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus reactivation from latency: validation of a “switch” model in vitro

(2016) Maria-Cristina Arcangeletti et al.   Virology Journal

Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency

(2016) Katie Caviness et al.   mBio

Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication

(2016) Jason Buehler et al.   PLoS Pathogens

Human Cytomegalovirus Latency: Approaching the Gordian Knot

(2016) Felicia Goodrum   Annual Review of Virology

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation

(2016) Matthias J. Reddehase   Frontiers in Immunology

Human Cytomegalovirus US28 Is Important for Latent Infection of Hematopoietic Progenitor Cells

(2015) Monica S. Humby et al.   JOURNAL OF VIROLOGY

Human CytomegalovirusUL135andUL136Genes Are Required for Postentry Tropism in Endothelial Cells

(2015) Farah Bughio et al.   JOURNAL OF VIROLOGY

Cytomegalovirus latency and reactivation: recent insights into an age old problem

(2015) Liane Dupont et al.   REVIEWS IN MEDICAL VIROLOGY

Human Cytomegalovirus Inhibits the PARsylation Activity of Tankyrase—A Potential Strategy for Suppression of the Wnt Pathway

(2015) Sujayita Roy et al.   Viruses-Basel

Humanized mouse models of human cytomegalovirus infection

(2015) Lindsey B Crawford et al.   Current Opinion in Virology

Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein

(2015) S. H. Lee et al.   Science Advances

The Human Cytomegalovirus UL133-138 Gene Locus Attenuates the Lytic Viral Cycle in Fibroblasts

(2015) Nirmal Dutta et al.   PLoS One

New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication

(2014) S. Roy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells

(2014) Richard J. Stanton et al.   Cell Host & Microbe

An Epistatic Relationship between the Viral Protein Kinase UL97 and the UL133-UL138 Latency Locus during the Human Cytomegalovirus Lytic Cycle

(2014) G. Li et al.   JOURNAL OF VIROLOGY

Complex Expression of the UL136 Gene of Human Cytomegalovirus Results in Multiple Protein Isoforms with Unique Roles in Replication

(2014) K. Caviness et al.   JOURNAL OF VIROLOGY

Antagonistic Determinants Controlling Replicative and Latent States of Human Cytomegalovirus Infection

(2014) M. Umashankar et al.   JOURNAL OF VIROLOGY

HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon

(2014) Emily Stevenson et al.   Viruses-Basel

The intimate relationship between human cytomegalovirus and the dendritic cell lineage

(2014) John Sinclair et al.   Frontiers in Microbiology

Wnt Modulating Agents Inhibit Human Cytomegalovirus Replication

(2013) Arun Kapoor et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Down-regulation of human cytomegalovirus UL138, a novel latency-associated determinant, by hcmv-miR-UL36

(2013) Yujing Huang et al.   JOURNAL OF BIOSCIENCES

Role of Herpes Simplex Virus VP11/12 Tyrosine-Based Motifs in Binding and Activation of the Src Family Kinase Lck and Recruitment of p85, Grb2, and Shc

(2013) U. Strunk et al.   JOURNAL OF VIROLOGY

The ULb' Region of the Human Cytomegalovirus Genome Confers an Increased Requirement for the Viral Protein Kinase UL97

(2013) D. Wang et al.   JOURNAL OF VIROLOGY

Latency-Associated Degradation of the MRP1 Drug Transporter During Latent Human Cytomegalovirus Infection

(2013) M. P. Weekes et al.   SCIENCE

Cis and Trans Acting Factors Involved in Human Cytomegalovirus Experimental and Natural Latent Infection of CD14 (+) Monocytes and CD34 (+) Cells

(2013) Cyprian C. Rossetto et al.   PLoS Pathogens

Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling

(2012) Leszek Kotula   FEBS LETTERS

Interactions between Proteins Encoded within the Human CytomegalovirusUL133-UL138Locus

(2012) Alex Petrucelli et al.   JOURNAL OF VIROLOGY

A Myeloid Progenitor Cell Line Capable of Supporting Human Cytomegalovirus Latency and Reactivation, Resulting in Infectious Progeny

(2012) Christine M. O'Connor et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Stimulates Monocyte-to-Macrophage Differentiation via the Temporal Regulation of Caspase 3

(2012) G. Chan et al.   JOURNAL OF VIROLOGY

HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14+ Cells

(2012) Lisa R. Keyes et al.   PLoS One

Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection

(2012) L. J. Terry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Cytomegalovirus Infection Dysregulates the Canonical Wnt/β-catenin Signaling Pathway

(2012) Magdalena Angelova et al.   PLoS Pathogens

CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor

(2011) Sissel Beate Rønning et al.   EXPERIMENTAL CELL RESEARCH

The Latency-Associated UL138 Gene Product of Human Cytomegalovirus Sensitizes Cells to Tumor Necrosis Factor Alpha (TNF- ) Signaling by Upregulating TNF-  Receptor 1 Cell Surface Expression

(2011) C. Montag et al.   JOURNAL OF VIROLOGY

The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance ULb'-Encoded Modulation of TNF-  Signaling

(2011) V. T. K. Le et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells

(2011) M. B. Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Human Cytomegalovirus Locus Modulates Cell Type-Specific Outcomes of Infection

(2011) Mahadevaiah Umashankar et al.   PLoS Pathogens

Nature and Duration of Growth Factor Signaling through Receptor Tyrosine Kinases Regulates HSV-1 Latency in Neurons

(2010) Vladimir Camarena et al.   Cell Host & Microbe

Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model

(2010) M. Shane Smith et al.   Cell Host & Microbe

A Dyn2–CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding

(2010) Barbara Schroeder et al.   EMBO JOURNAL

PI3K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus Is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes

(2010) G. Chan et al.   JOURNAL OF IMMUNOLOGY

Stress-Inducible Alternative Translation Initiation of Human Cytomegalovirus Latency Protein pUL138

(2010) L. Grainger et al.   JOURNAL OF VIROLOGY

Cellular and Viral Control over the Initial Events of Human Cytomegalovirus Experimental Latency in CD34+ Cells

(2010) R. T. Saffert et al.   JOURNAL OF VIROLOGY

Experimental human cytomegalovirus latency in CD14+ monocytes

(2010) D. Hargett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection

(2010) Michael J. Cannon et al.   REVIEWS IN MEDICAL VIROLOGY

Inhibition of epidermal growth factor receptor (EGFR) expression by human cytomegalovirus correlates with an increase in the expression and binding of Wilms' Tumour 1 protein to the EGFR promoter

(2009) I. Jafferji et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency

(2009) L. Peng et al.   JOURNAL OF GENERAL VIROLOGY

Characterization of a Novel Golgi Apparatus-Localized Latency Determinant Encoded by Human Cytomegalovirus

(2009) A. Petrucelli et al.   JOURNAL OF VIROLOGY

The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

(2008) Irene M. Min et al.   Cell Stem Cell