Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

(2018) Laura A. McAllister et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2018) Mojgan Aghazadeh Tabrizi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

(2018) Gaurav Bedse et al.   Translational Psychiatry

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

(2018) Justin S. Cisar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors

(2018) Jumpei Aida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators

(2018) Jason R. Clapper et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

The endocannabinoid system as a target for novel anxiolytic drugs

(2017) Sachin Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors

(2016) Wei Tuo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses

(2016) Y Wang et al.   MOLECULAR PSYCHIATRY

Endocannabinoids and sleep

(2016) Oscar Prospéro-García et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Endocannabinoid Signaling Regulates Sleep Stability

(2016) Matthew J. Pava et al.   PLoS One

Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors

(2016) Buqing Yi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

(2015) William H. Parsons et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endocannabinoid Degradation Inhibition Improves Neurobehavioral Function, Blood–Brain Barrier Integrity, and Neuroinflammation following Mild Traumatic Brain Injury

(2015) Paige S. Katz et al.   JOURNAL OF NEUROTRAUMA

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

(2015) E.L. von Rüden et al.   NEUROBIOLOGY OF DISEASE

Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans

(2015) Jose Cortes-Briones et al.   NEUROPSYCHOPHARMACOLOGY

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

(2015) Guy Griebel et al.   Scientific Reports

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

(2014) Gloria Hernández-Torres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and characterization of a new reversible MAGL inhibitor

(2014) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelinationin vivo

(2014) Ana Bernal-Chico et al.   GLIA

Hippocampal Metaplasticity Is Required for the Formation of Temporal Associative Memories

(2014) J. Xu et al.   JOURNAL OF NEUROSCIENCE

In vivocharacterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects

(2013) B M Ignatowska-Jankowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic potential of cannabinoid medicines

(2013) P. J. Robson   Drug Testing and Analysis

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks

(2013) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

(2012) Jing Han et al.   CELL

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders

(2012) Matthew Hill et al.   CNS & Neurological Disorders-Drug Targets

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

(2012) Sudeshna Ghosh et al.   LIFE SCIENCES

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony

(2012) C. Sales-Carbonell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders

(2012) Ana Franky Carvalho et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses

(2011) Arnau Busquets-Garcia et al.   BIOLOGICAL PSYCHIATRY

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

(2011) Céline Schalk-Hihi et al.   PROTEIN SCIENCE

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls

(2010) Matthew W Buczynski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

(2010) Douglas S Johnson et al.   Future Medicinal Chemistry

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Good night and good luck: Norepinephrine in sleep pharmacology

(2009) Heather A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of cannabinoid-1 receptors in the locus coeruleus: Relationship with mu-opioid receptors

(2009) Jillian L. Scavone et al.   BRAIN RESEARCH

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

(2009) B. Pan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress

(2009) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Activation of Cannabinoid-1 Receptors Disrupts Sensory Gating and Neuronal Oscillation: Relevance to Schizophrenia

(2008) Mihály Hajós et al.   BIOLOGICAL PSYCHIATRY

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

(2008) M. Hill et al.   PHARMACOPSYCHIATRY

Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex

(2007) M.E. Page et al.   NEUROSCIENCE LETTERS