Sharing vitamins: Cobamides unveil microbial interactions

Identification and characterization of a bacterial core methionine synthase

(2020) Darja Deobald et al.   Scientific Reports

A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds

(2020) S. Rempel et al.   NATURE

A new class of phosphoribosyltransferase involved in cobamide biosynthesis is found in methanogenic archaea and cyanobacteria

(2019) Victoria L Jeter et al.   BIOCHEMISTRY

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

(2019) Konstanze T. Schiessl et al.   Nature Communications

The clinical presentation of cobalamin-related disorders: From acquired deficiencies to inborn errors of absorption and intracellular pathways

(2019) Martina Huemer et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Vitamin B12 , folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation

(2019) D. Sean Froese et al.   JOURNAL OF INHERITED METABOLIC DISEASE

RiboD: a comprehensive database for prokaryotic riboswitches

(2019) Sumit Mukherjee et al.   BIOINFORMATICS

Comparative and Functional Algal Genomics

(2019) Crysten E. Blaby-Haas et al.   Annual Review of Plant Biology

MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies

(2019) Daniel J. Ryan et al.   ANALYTICAL CHEMISTRY

Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin

(2019) Matthew I. Radle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145

(2019) Sergii Krysenko et al.   mBio

Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin B12 Scavenging

(2019) James R. Aretakis et al.   mSystems

MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation

(2019) Jonathan W. Picking et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral vitamin B12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice

(2019) Caleb J Kelly et al.   Gut Microbes

Metagenomic and chemical characterization of soil cobalamin production

(2019) Xinda Lu et al.   ISME Journal

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme

(2019) Olga M. Sokolovskaya et al.   mBio

Flexible cobamide metabolism in Clostridioides (Clostridium) difficile 630 Δerm

(2019) Amanda N. Shelton et al.   JOURNAL OF BACTERIOLOGY

Specificity of cobamide remodeling, uptake and utilization in Vibrio cholerae

(2019) Amy T. Ma et al.   MOLECULAR MICROBIOLOGY

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

(2019) Po-Hsiang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Methanosarcina mazei MM2060 Gene Encodes a Bifunctional Kinase/Decarboxylase Enzyme Involved in Cobamide Biosynthesis

(2018) Norbert K. Tavares et al.   BIOCHEMISTRY

Selective Utilization of Benzimidazolyl-Norcobamides as Cofactors by the Tetrachloroethene Reductive Dehalogenase of Sulfurospirillum multivorans

(2018) Sebastian Keller et al.   JOURNAL OF BACTERIOLOGY

Ecology and evolution of metabolic cross-feeding interactions in bacteria

(2018) Glen D'Souza et al.   NATURAL PRODUCT REPORTS

Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions

(2018) James E. Cassat et al.   Science Translational Medicine

Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

(2018) Joana A Santos et al.   eLife

Identification and quantitation of cobalamin and cobalamin analogues in human feces

(2018) Robert H Allen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Cobalamin Activity-Based Probe Enables Microbial Cell Growth and Finds New Cobalamin-Protein Interactions across Domains

(2018) Joshua J. Rosnow et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cross-exchange of B-vitamins underpins a mutualistic interaction between Ostreococcus tauri and Dinoroseobacter shibae

(2018) Matthew B. Cooper et al.   ISME Journal

Rhodobacterales use a unique L-threonine kinase for the assembly of the nucleotide loop of coenzyme B12

(2018) Norbert K. Tavares et al.   MOLECULAR MICROBIOLOGY

Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM

(2018) S. Rempel et al.   Nature Communications

Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

(2018) Aaron G Wexler et al.   eLife

B Vitamins and Their Congeners as Potential Drivers of Microbial Community Composition in an Oligotrophic Marine Ecosystem

(2018) C. P. Suffridge et al.   Journal of Geophysical Research-Biogeosciences

Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics

(2018) Amanda N. Shelton et al.   ISME Journal

Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition

(2018) Xuan Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sacrificial Cobalt–Carbon Bond Homolysis in Coenzyme B12 as a Cofactor Conservation Strategy

(2018) Gregory C. Campanello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an in vitro Colon Simulation

(2018) Yuanyuan Xu et al.   Frontiers in Microbiology

Guided cobamide biosynthesis for heterologous production of reductive dehalogenases

(2018) Torsten Schubert et al.   Microbial Biotechnology

Mechanistic basis of vitamin B12 and cobinamide salvaging by the Vibrio species

(2018) Shubhangi Agarwal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Underlying mechanisms for syntrophic metabolism of essential enzyme cofactors in microbial communities

(2017) Margaret F Romine et al.   ISME Journal

Purinyl-cobamide is a native prosthetic group of reductive dehalogenases

(2017) Jun Yan et al.   Nature Chemical Biology

Elucidation of roles for vitamin B12in regulation of folate, ubiquinone, and methionine metabolism

(2017) Margaret F. Romine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatic analysis of riboswitch structures uncovers variant classes with altered ligand specificity

(2017) Zasha Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

(2017) Clara Belzer et al.   mBio

The Exometabolome of Two Model Strains of the Roseobacter Group: A Marketplace of Microbial Metabolites

(2017) Gerrit Wienhausen et al.   Frontiers in Microbiology

Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F

(2017) S. A. Mireku et al.   Scientific Reports

In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment

(2017) Jan Zarzycki et al.   Scientific Reports

Total Synthesis, Structure, and Biological Activity of Adenosylrhodibalamin, the Non-Natural Rhodium Homologue of Coenzyme B12

(2016) Florian J. Widner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyanobacteria and Eukaryotic Algae Use Different Chemical Variants of Vitamin B12

(2016) Katherine Emma Helliwell et al.   CURRENT BIOLOGY

Evidence for quorum sensing and differential metabolite production by a marine bacterium in response to DMSP

(2016) Winifred M Johnson et al.   ISME Journal

TheSMUL_1544Gene Product Governs Norcobamide Biosynthesis in the Tetrachloroethene-Respiring Bacterium Sulfurospirillum multivorans

(2016) Sebastian Keller et al.   JOURNAL OF BACTERIOLOGY

1,2-Propanediol Dehydration inRoseburia inulinivorans

(2016) Joseph W. LaMattina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two distinct pools of B12analogs reveal community interdependencies in the ocean

(2016) Katherine R. Heal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling

(2016) William H. DePas et al.   mBio

Experimental Strategies for Functional Annotation and Metabolism Discovery: Targeted Screening of Solute Binding Proteins and Unbiased Panning of Metabolomes

(2015) Matthew W. Vetting et al.   BIOCHEMISTRY

Antivitamins for Medicinal Applications

(2015) Felix Zelder et al.   CHEMBIOCHEM

The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi

(2015) Jun Yan et al.   ISME Journal

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis

(2015) Angad P. Mehta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anaerobic biosynthesis of the lower ligand of vitamin B12

(2015) Amrita B. Hazra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phytoplankton–bacterial interactions mediate micronutrient colimitation at the coastal Antarctic sea ice edge

(2015) Erin M. Bertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin B 12 modulates the transcriptome of the skin microbiota in acne pathogenesis

(2015) Dezhi Kang et al.   Science Translational Medicine

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes

(2015) Stefanía Magnúsdóttir et al.   Frontiers in Genetics

Global prevalence and distribution of genes and microorganisms involved in mercury methylation

(2015) M. Podar et al.   Science Advances

Sustainable Growth of Dehalococcoides mccartyi 195 by Corrinoid Salvaging and Remodeling in Defined Lactate-Fermenting Consortia

(2014) Yujie Men et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

(2014) Jessica A. Ferreyra et al.   Cell Host & Microbe

Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut

(2014) Patrick H. Degnan et al.   Cell Host & Microbe

Vitamin B 12 as a Modulator of Gut Microbial Ecology

(2014) Patrick H. Degnan et al.   Cell Metabolism

Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities

(2014) Yujie Men et al.   ENVIRONMENTAL MICROBIOLOGY

LESS IS MORE: SELECTIVE ADVANTAGES CAN EXPLAIN THE PREVALENT LOSS OF BIOSYNTHETIC GENES IN BACTERIA

(2014) Glen D'Souza et al.   EVOLUTION

Fundamental shift in vitamin B12 eco-physiology of a model alga demonstrated by experimental evolution

(2014) Katherine E Helliwell et al.   ISME Journal

Aquatic metagenomes implicate Thaumarchaeota in global cobalamin production

(2014) Andrew C Doxey et al.   ISME Journal

Syntrophic exchange in synthetic microbial communities

(2014) M. T. Mee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated circuit-based electrochemical sensor for spatially resolved detection of redox-active metabolites in biofilms

(2014) Daniel L. Bellin et al.   Nature Communications

A bioassay for the detection of benzimidazoles reveals their presence in a range of environmental samples

(2014) Terence S. Crofts et al.   Frontiers in Microbiology

Nutrient cross-feeding in the microbial world

(2014) Erica C. Seth et al.   Frontiers in Microbiology

Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity

(2013) Terence S. Crofts et al.   CHEMISTRY & BIOLOGY

Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12

(2013) Amrita B. Hazra et al.   CHEMISTRY & BIOLOGY

Exogenous 5,6-dimethylbenzimidazole caused production of a non-functional tetrachloroethene reductive dehalogenase inSulfurospirillum multivorans

(2013) Sebastian Keller et al.   ENVIRONMENTAL MICROBIOLOGY

Growth Inhibition of Sporomusa ovata by Incorporation of Benzimidazole Bases into Cobamides

(2013) K. C. Mok et al.   JOURNAL OF BACTERIOLOGY

The Genetic Basis for Bacterial Mercury Methylation

(2013) J. M. Parks et al.   SCIENCE

A vitamin B12 transporter in Mycobacterium tuberculosis

(2013) K. Gopinath et al.   Open Biology

Unexpected Specificity of Interspecies Cobamide Transfer from Geobacter spp. to Organohalide-Respiring Dehalococcoides mccartyi Strains

(2012) Jun Yan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Versatility in Corrinoid Salvaging and Remodeling Pathways Supports Corrinoid-Dependent Metabolism in Dehalococcoides mccartyi

(2012) Shan Yi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The anaerobic biosynthesis of vitamin B12

(2012) Simon J. Moore et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mutualistic interactions between vitamin B12-dependent algae and heterotrophic bacteria exhibit regulation

(2012) Elena Kazamia et al.   ENVIRONMENTAL MICROBIOLOGY

An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis

(2012) Evelyne Deery et al.   Nature Chemical Biology

Insights into the Evolution of Vitamin B12 Auxotrophy from Sequenced Algal Genomes

(2011) K. E. Helliwell et al.   MOLECULAR BIOLOGY AND EVOLUTION

ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis

(2011) Chi Ho Chan et al.   MOLECULAR MICROBIOLOGY

Methyladeninylcobamide functions as the cofactor of methionine synthase in a Cyanobacterium,Spirulina platensisNIES-39

(2010) Yuri Tanioka et al.   FEBS LETTERS

A new pathway for the synthesis of α-ribazole-phosphate in Listeria innocua

(2010) Michael J. Gray et al.   MOLECULAR MICROBIOLOGY

Most harmful algal bloom species are vitamin B1 and B12 auxotrophs

(2010) Y. Z. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization

(2009) Yan Zhang et al.   BMC GENOMICS

Apparent ruminal synthesis and intestinal disappearance of vitamin B12 and its analogs in dairy cows

(2009) C.L. Girard et al.   JOURNAL OF DAIRY SCIENCE

The cobinamide amidohydrolase (cobyric acid-forming) CbiZ enzyme: a critical activity of the cobamide remodelling system ofRhodobacter sphaeroides

(2009) Michael J. Gray et al.   MOLECULAR MICROBIOLOGY

The Corrin Moiety of Coenzyme B12is the Determinant for Switching thebtuBRiboswitch ofE. coli

(2008) Sofia Gallo et al.   CHEMBIOCHEM

Riboswitches that Sense S-adenosylhomocysteine and Activate Genes Involved in Coenzyme Recycling

(2008) Joy Xin Wang et al.   MOLECULAR CELL