Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

Preclinical evaluation ofNUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

(2018) Rina Nishii et al.   BLOOD

Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis

(2018) Sarah Cargnin et al.   PHARMACOLOGICAL RESEARCH

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

(2018) Mary V. Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogene Variation Consortium Gene Introduction: NUDT15

(2018) Jun J. Yang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

(2016) Takaya Moriyama et al.   NATURE GENETICS

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

(2015) Marieke J.H. Coenen et al.   GASTROENTEROLOGY

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

(2013) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS