Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort

(2016) Meghna Jani et al.   ANNALS OF THE RHEUMATIC DISEASES

CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets

(2016) E. C. Schofield et al.   BIOINFORMATICS

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

(2016) Biola M. Javierre et al.   CELL

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis

(2016) Dao Xuan Nguyen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Previously reported PDE3A–SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort

(2016) Samantha Louise Smith et al.   PHARMACOGENOMICS

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

(2016) Solveig K. Sieberts et al.   Nature Communications

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C

(2016) Paul Martin et al.   PLoS One

Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context

(2015) Mathias Rask-Andersen et al.   HUMAN GENETICS

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

(2015) Borbala Mifsud et al.   NATURE GENETICS

Limitations of GCTA as a solution to the missing heritability problem

(2015) Siddharth Krishna Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

(2015) Yayi Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci

(2015) Paul Martin et al.   Nature Communications

Clinical Utility of Random Anti-Tumor Necrosis Factor Drug-Level Testing and Measurement of Antidrug Antibodies on the Long-Term Treatment Response in Rheumatoid Arthritis

(2015) Meghna Jani et al.   Arthritis & Rheumatology

Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis

(2014) Maša Umićević Mirkov et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficient haplotype matching and storage using the positional Burrows-Wheeler transform (PBWT)

(2014) R. Durbin   BIOINFORMATICS

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

(2014) James Bluett et al.   RHEUMATOLOGY

GWAS replication study confirms the association of PDE3A–SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis

(2013) Isabel Acosta-Colman et al.   PHARMACOGENOMICS

Lack of Association of Variants Previously Associated with Anti-TNF Medication Response in Rheumatoid Arthritis Patients: Results from a Homogeneous Greek Population

(2013) Maria I. Zervou et al.   PLoS One

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

(2013) Jing Cui et al.   PLoS Genetics

Development and Validation of Modified Disease Activity Scores in Rheumatoid Arthritis: Superior Correlation With Magnetic Resonance Imaging-Detected Synovitis and Radiographic Progression

(2013) Joshua F. Baker et al.   Arthritis & Rheumatology

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

(2012) Maša Umiċeviċ Mirkov et al.   ANNALS OF THE RHEUMATIC DISEASES

Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort

(2011) Darren Plant et al.   ARTHRITIS AND RHEUMATISM

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Personalized medicine in rheumatoid arthritis: Miles to go before we sleep

(2010) Robert M. Plenge et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci

(2010) Darren Plant et al.   ARTHRITIS AND RHEUMATISM

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS