Pathogenesis and Pathophysiology of Pneumococcal Meningitis

Ly-6G+CCR2- Myeloid Cells Rather Than Ly-6ChighCCR2+ Monocytes Are Required for the Control of Bacterial Infection in the Central Nervous System

(2014) A. Mildner et al.   JOURNAL OF IMMUNOLOGY

Mucosal Clearance of Capsule-Expressing Bacteria Requires Both TLR and Nucleotide-Binding Oligomerization Domain 1 Signaling

(2014) T. A. Zola et al.   JOURNAL OF IMMUNOLOGY

Mannose-Binding Lectin (MBL) Facilitates Opsonophagocytosis of Yeasts but Not of Bacteria despite MBL Binding

(2014) N. Brouwer et al.   JOURNAL OF IMMUNOLOGY

Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial

(2011) Katherine MB Ajdukiewicz et al.   LANCET INFECTIOUS DISEASES

Glycerol in bacterial meningitis: one strike and out?

(2011) Matthijs C Brouwer et al.   LANCET INFECTIOUS DISEASES

Adjunctive Dexamethasone Affects the Expression of Genes Related to Inflammation, Neurogenesis and Apoptosis in Infant Rat Pneumococcal Meningitis

(2011) Cornelia Blaser et al.   PLoS One

Attenuation of Cerebrospinal Fluid Inflammation by the Nonbacteriolytic Antibiotic Daptomycin versus That by Ceftriaxone in Experimental Pneumococcal Meningitis

(2010) D. Grandgirard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TAK1 targeting by glucocorticoids determines JNK and I B regulation in Toll-like receptor-stimulated macrophages

(2010) S. Bhattacharyya et al.   BLOOD

Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis

(2010) Christian Østergaard et al.   BMC INFECTIOUS DISEASES

Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis

(2010) Cornelia Blaser et al.   BMC INFECTIOUS DISEASES

Dexamethasone prevents LPS-induced microglial activation and astroglial impairment in an experimental bacterial meningitis co-culture model

(2010) Daniel Hinkerohe et al.   BRAIN RESEARCH

Immunization of Mice with Single PspA Fragments Induces Antibodies Capable of Mediating Complement Deposition on Different Pneumococcal Strains and Cross-Protection

(2010) A. T. Moreno et al.   Clinical and Vaccine Immunology

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

(2010) M. C. Brouwer et al.   CLINICAL MICROBIOLOGY REVIEWS

Inflammation and coagulation

(2010) Marcel Levi et al.   CRITICAL CARE MEDICINE

New understandings on the pathophysiology of bacterial meningitis

(2010) Uwe Koedel et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Mechanisms of injury in bacterial meningitis

(2010) Joachim Gerber et al.   CURRENT OPINION IN NEUROLOGY

Central memory CD4+ T cells dominate the normal cerebrospinal fluid

(2010) Marieke T. de Graaf et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced Susceptibility to Acute Pneumococcal Otitis Media in Mice Deficient in Complement C1qa, Factor B, and Factor B/C2

(2010) H. H. Tong et al.   INFECTION AND IMMUNITY

The Proline-Rich Region of Pneumococcal Surface Proteins A and C Contains Surface-Accessible Epitopes Common to All Pneumococci and Elicits Antibody-Mediated Protection against Sepsis

(2010) C. C. Daniels et al.   INFECTION AND IMMUNITY

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

(2010) Jason W. Rosch et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

(2010) K. Tsuchiya et al.   JOURNAL OF IMMUNOLOGY

Outbreaks of serious pneumococcal disease in closed settings in the post-antibiotic era: A systematic review

(2010) Chikwe Ihekweazu et al.   JOURNAL OF INFECTION

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

(2010) Simon S Jensen et al.   Journal of Inflammation-London

TNF-α, IL-1β, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae

(2010) Tatiana Barichello et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Systemic infection and delirium: when cytokines and acetylcholine collide

(2010) Willem A van Gool et al.   LANCET

Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data

(2010) Diederik van de Beek et al.   LANCET NEUROLOGY

Adjunctive dexamethasone in meningitis: does value depend on clinical setting?

(2010) Peter McIntyre   LANCET NEUROLOGY

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections

(2010) Inga Jensch et al.   MOLECULAR MICROBIOLOGY

Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis

(2010) A. Kadioglu et al.   Molecular Oral Microbiology

Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis

(2010) Mervyn D. I. Vergouwen et al.   Neurocritical Care

Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis

(2010) M. C. Brouwer et al.   NEUROLOGY

Nosocomial Bacterial Meningitis

(2010) Diederik van de Beek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Tissue factor expression in blood cells

(2010) Bjarne Østerud   THROMBOSIS RESEARCH

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza Virus Infection Decreases Tracheal Mucociliary Velocity and Clearance ofStreptococcus pneumoniae

(2009) Lynnelle A. Pittet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone

(2009) U. Egermann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tissue Factor in Coagulation

(2009) Saulius Butenas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis

(2009) S. Yubero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

(2009) D. M. Ferreira et al.   Clinical and Vaccine Immunology

Immunological and Biochemical Correlates of Adjunctive Dexamethasone in Vietnamese Adults with Bacterial Meningitis

(2009) Nguyen Thi Hoang Mai et al.   CLINICAL INFECTIOUS DISEASES

Short-term rifampicin pretreatment reduces inflammation and neuronal cell death in a rabbit model of bacterial meningitis*

(2009) Annette Spreer et al.   CRITICAL CARE MEDICINE

Polymorphic Receptors of the Innate Immune System (MBL/MASP-2 and TLR2/4) and Susceptibility to Pneumococcal Bacteremia in HIV-Infected Patients: A Case-Control Study

(2009) Juan Horcajada et al.   CURRENT HIV RESEARCH

Toll-Like Receptor Stimulation Enhances Phagocytosis and Intracellular Killing of Nonencapsulated and Encapsulated Streptococcus pneumoniae by Murine Microglia

(2009) S. Ribes et al.   INFECTION AND IMMUNITY

Early Bacterial Colonization Induces Toll-Like Receptor-Dependent Transforming Growth Factor   Signaling in the Epithelium

(2009) C. Beisswenger et al.   INFECTION AND IMMUNITY

Role for Toll-Like Receptor 2 in the Immune Response to Streptococcus pneumoniae Infection in Mouse Otitis Media

(2009) F. Han et al.   INFECTION AND IMMUNITY

Streptococcus pneumoniae Resistance to Complement-Mediated Immunity Is Dependent on the Capsular Serotype

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

The Effects of PspC on Complement-Mediated Immunity to Streptococcus pneumoniae Vary with Strain Background and Capsular Serotype

(2009) J. Yuste et al.   INFECTION AND IMMUNITY

Role of Complement in Host Defense against Pneumococcal Otitis Media

(2009) V. Sabharwal et al.   INFECTION AND IMMUNITY

Circulating levels of vasoactive peptides in patients with acute bacterial meningitis

(2009) Ronan M. G. Berg et al.   INTENSIVE CARE MEDICINE

Influenza and bacterial pneumonia

(2009) A.M. Geddes   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells

(2009) S. Bergmann et al.   JOURNAL OF CELL SCIENCE

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

Detection of Streptococcus pneumoniae Strain Cocolonization in the Nasopharynx

(2009) S. D. Brugger et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Complement Factor H, a Marker of Self Protects against Experimental Autoimmune Encephalomyelitis

(2009) M. R. Griffiths et al.   JOURNAL OF IMMUNOLOGY

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Regulation of activin A synthesis in microglial cells: Pathophysiological implications for bacterial meningitis

(2009) Henrik Wilms et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Streptococcus Adherence and Colonization

(2009) A. H. Nobbs et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis

(2009) Charlene Cavalheiro de Menezes et al.   NEUROCHEMICAL RESEARCH

Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis

(2009) E. S. Schut et al.   NEUROLOGY

Tumor necrosis factor alpha (TNF-α) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae

(2009) Tatiana Barichello et al.   NEUROSCIENCE LETTERS

Bacterial Pathogens and Death during the 1918 Influenza Pandemic

(2009) Yu-Wen Chien et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hearing Impairment in Childhood Bacterial Meningitis Is Little Relieved by Dexamethasone or Glycerol

(2009) H. Peltola et al.   PEDIATRICS

The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model

(2009) D. Bogaert et al.   VACCINE

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media

(2008) Jun Shimada et al.   BMC INFECTIOUS DISEASES

Dexamethasone regulation of matrix metalloproteinase expression in experimental pneumococcal meningitis

(2008) Xinjie Liu et al.   BRAIN RESEARCH

Polar bacterial invasion and translocation ofStreptococcus suisacross the blood-cerebrospinal fluid barrierin vitro

(2008) Tobias Tenenbaum et al.   CELLULAR MICROBIOLOGY

Mannose-Binding Lectin Genotypes in Susceptibility to Community-Acquired Pneumonia

(2008) Henrik Endeman et al.   CHEST

Caspases inhibition decreases neurological sequelae in meningitis*

(2008) Jose Irazuzta et al.   CRITICAL CARE MEDICINE

Pneumolysin: A Double-Edged Sword During the Host-Pathogen Interaction

(2008) Helen Marriott et al.   CURRENT MOLECULAR MEDICINE

Virulence factors in pneumococcal respiratory pathogenesis

(2008) Julie A Preston et al.   Future Microbiology

NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens

(2008) Vinita S. Chauhan et al.   GLIA

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway

(2008) J. Yuste et al.   INFECTION AND IMMUNITY

The Interaction of Streptococcus pneumoniae with Plasmin Mediates Transmigration across Endothelial and Epithelial Monolayers by Intercellular Junction Cleavage

(2008) C. Attali et al.   INFECTION AND IMMUNITY

Increased risk of serious pneumococcal disease in patients with asthma

(2008) Young J. Juhn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of Staphylococcus aureus Catalase in Niche Competition against Streptococcus pneumoniae

(2008) B. Park et al.   JOURNAL OF BACTERIOLOGY

Hydrogen Peroxide-Mediated Interference Competition by Streptococcus pneumoniae Has No Significant Effect on Staphylococcus aureus Nasal Colonization of Neonatal Rats

(2008) E. Margolis   JOURNAL OF BACTERIOLOGY

A Second Pilus Type in Streptococcus pneumoniae Is Prevalent in Emerging Serotypes and Mediates Adhesion to Host Cells

(2008) F. Bagnoli et al.   JOURNAL OF BACTERIOLOGY

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

(2008) Matthias Klein et al.   JOURNAL OF INFECTIOUS DISEASES

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

(2008) Robert Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis

(2008) Cristina P Marques et al.   JOURNAL OF NEUROVIROLOGY

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

(2008) Matthijs C Brouwer et al.   LANCET INFECTIOUS DISEASES

Interaction of pneumococcal phase variation and middle ear pressure/gas composition: An in vitro model of simulated otitis media

(2008) Ha-Sheng Li-Korotky et al.   MICROBIAL PATHOGENESIS

The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae

(2008) Xin-Ming Song et al.   MICROBIAL PATHOGENESIS

Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae

(2008) Estella A. Koppel et al.   MOLECULAR IMMUNOLOGY

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae

(2008) Jin-Yeon Park et al.   NEUROSCIENCE LETTERS

Increase in Serum Osmolality Is Possible Mechanism for the Beneficial Effects of Glycerol in Childhood Bacterial Meningitis

(2008) Sunit Singhi et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Drug Insight: steroids in CNS infectious diseases—new indications for an old therapy

(2008) Michael T Fitch et al.   Nature clinical practice. Neurology

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

(2008) Kimberly M. Davis et al.   PLoS Pathogens

Pooled Analysis of 2,408 Cases of Acute Adult Purulent Meningitis from Turkey

(2007) Bilgin Arda et al.   MEDICAL PRINCIPLES AND PRACTICE

Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae

(2007) Martina M. Ochs et al.   MICROBIAL PATHOGENESIS