LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone–growth cone communication

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

(2020) Tomoki Kuwahara et al.   Frontiers in Neuroscience

Breaking symmetry – cell polarity signaling pathways in growth cone guidance and synapse formation

(2020) Yimin Zou   CURRENT OPINION IN NEUROBIOLOGY

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Understanding axon guidance: are we nearly there yet?

(2018) Esther T. Stoeckli   DEVELOPMENT

Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway

(2018) Austen A. Sitko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Planar cell polarity in development and disease

(2017) Mitchell T. Butler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling

(2017) Chun-Hao Chen et al.   PLoS Genetics

Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2

(2017) Keisuke Onishi et al.   eLife

Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance

(2016) Simon D. Sun et al.   BMC NEUROSCIENCE

The planar cell polarity protein Vangl2 is required for retinal axon guidance

(2015) Vicki Leung et al.   Developmental Neurobiology

Canonical wnt signaling is required for commissural axon guidance

(2015) Evelyn C. Avilés et al.   Developmental Neurobiology

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening

(2015) Nicholas J. Lavalley et al.   HUMAN MOLECULAR GENETICS

The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila

(2015) R. Gombos et al.   JOURNAL OF NEUROSCIENCE

Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth inCaenorhabditis elegans

(2015) Chaogu Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon guidance and injury—lessons from Wnts and Wnt signaling

(2014) Keisuke Onishi et al.   CURRENT OPINION IN NEUROBIOLOGY

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

(2014) Loukia Parisiadou et al.   NATURE NEUROSCIENCE

Loss of Dishevelleds Disrupts Planar Polarity in Ependymal Motile Cilia and Results in Hydrocephalus

(2014) Shinya Ohata et al.   NEURON

What axons tell each other: axon–axon signaling in nerve and circuit assembly

(2013) Liang Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons

(2013) Elvis Huarcaya Najarro et al.   DEVELOPMENTAL BIOLOGY

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

(2013) Fumitaka Kawakami et al.   FEBS Journal

Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance

(2013) K. Onishi et al.   JOURNAL OF NEUROSCIENCE

Neuropilin2 regulates the guidance of post-crossing spinal commissural axons in a subtype-specific manner

(2013) Tracy S Tran et al.   Neural Development

The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo

(2011) Eli M. Mrkusich et al.   DEVELOPMENTAL BIOLOGY

Vangl2 Promotes Wnt/Planar Cell Polarity-like Signaling by Antagonizing Dvl1-Mediated Feedback Inhibition in Growth Cone Guidance

(2011) Beth Shafer et al.   DEVELOPMENTAL CELL

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations

(2011) Etsuro Ohta et al.   FEBS LETTERS

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

The Wnt5/Planar Cell Polarity Pathway Regulates Axonal Development of the Drosophila Mushroom Body Neuron

(2011) K. Shimizu et al.   JOURNAL OF NEUROSCIENCE

Sonic Hedgehog Guides Post-Crossing Commissural Axons Both Directly and Indirectly by Regulating Wnt Activity

(2010) E. Domanitskaya et al.   JOURNAL OF NEUROSCIENCE

Wnt/Planar Cell Polarity Signaling Controls the Anterior-Posterior Organization of Monoaminergic Axons in the Brainstem

(2010) A. G. Fenstermaker et al.   JOURNAL OF NEUROSCIENCE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

(2010) Susanne Zach et al.   PLoS One

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

(2009) Rosa M. Sancho et al.   HUMAN MOLECULAR GENETICS

Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1

(2009) Oshri Avraham et al.   Neural Development

The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signaling

(2008) Jun Wu et al.   DEVELOPMENTAL CELL

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

(2008) Anthony K.F. Liou et al.   NEUROBIOLOGY OF DISEASE

Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra

(2008) Baek-Soo Han et al.   NEUROSCIENCE LETTERS