Pathogen perception by NLRs in plants and animals: Parallel worlds

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Protein trafficking during plant innate immunity

(2016) Wen-Ming Wang et al.   Journal of Integrative Plant Biology

TNL-mediated immunity inArabidopsisrequires complex regulation of the redundantADR1gene family

(2016) Oliver Xiaoou Dong et al.   NEW PHYTOLOGIST

Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread

(2016) Thomas Kroj et al.   NEW PHYTOLOGIST

Using decoys to expand the recognition specificity of a plant disease resistance protein

(2016) S. H. Kim et al.   SCIENCE

Structure and evolutionary history of a large family of NLR proteins in the zebrafish

(2016) Kerstin Howe et al.   Open Biology

IBS: an illustrator for the presentation and visualization of biological sequences: Fig. 1.

(2015) Wenzhong Liu et al.   BIOINFORMATICS

Treasure Your Exceptions: Unusual Domains in Immune Receptors Reveal Host Virulence Targets

(2015) Marc T. Nishimura et al.   CELL

A Receptor Pair with an Integrated Decoy Converts Pathogen Disabling of Transcription Factors to Immunity

(2015) Clémentine Le Roux et al.   CELL

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors

(2015) Panagiotis F. Sarris et al.   CELL

The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants

(2015) Guoxun Wang et al.   Cell Host & Microbe

Exploiting Combinatorial Interactions to Expand NLR Specificity

(2015) Roger W. Innes   Cell Host & Microbe

The NLRP1 inflammasomes

(2015) Joseph Chavarría-Smith et al.   IMMUNOLOGICAL REVIEWS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

The Potato Nucleotide-binding Leucine-rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-dependent DNA-deforming Protein

(2015) Stepan Fenyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

(2015) Jens Kortmann et al.   JOURNAL OF IMMUNOLOGY

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Helper NLR proteins NRC2a/b and NRC3 but not NRC1 are required for Pto-mediated cell death and resistance inNicotiana benthamiana

(2015) Chih-Hang Wu et al.   NEW PHYTOLOGIST

Rice Exo70 interacts with a fungal effector,AVR-Pii, and is required for AVR-Pii-triggered immunity

(2015) Koki Fujisaki et al.   PLANT JOURNAL

CC-NBS-LRR-Type R Proteins for Rice Blast Commonly Interact with Specific WRKY Transcription Factors

(2015) Xinqiong Liu et al.   PLANT MOLECULAR BIOLOGY REPORTER

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

(2015) Magdalena Matusiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

(2015) Christoph A. Diebolder et al.   STRUCTURE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the exo70B1 Mutant

(2015) Ting Zhao et al.   PLoS Genetics

Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

(2015) Guan-Feng Wang et al.   PLoS Pathogens

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

(2015) A Maqbool et al.   eLife

The “sensor domains” of plant NLR proteins: more than decoys?

(2015) Chih-Hang Wu et al.   Frontiers in Plant Science

Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour

(2015) Fang Xu et al.   Scientific Reports

Massive expansion and functional divergence of innate immune genes in a protostome

(2015) Linlin Zhang et al.   Scientific Reports

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Inflammasome: Putting the Pieces Together

(2014) Jürgen Ruland   CELL

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life

(2014) Ralf Weßling et al.   Cell Host & Microbe

The NB‐LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance

(2014) Stella Césari et al.   EMBO JOURNAL

Distinct Regions of NLRP1B Are Required To Respond to Anthrax Lethal Toxin and Metabolic Inhibition

(2014) Jana Neiman-Zenevich et al.   INFECTION AND IMMUNITY

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

P-Loop-Dependent NLR SNC1 Can Oligomerize and Activate Immunity in the Nucleus

(2014) Fang Xu et al.   Molecular Plant

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

The Arabidopsis immune adaptor SRFR1 interacts with TCP transcription factors that redundantly contribute to effector-triggered immunity

(2014) Sang Hee Kim et al.   PLANT JOURNAL

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paired Plant Immune Receptors

(2014) M. T. Nishimura et al.   SCIENCE

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

Plant pattern-recognition receptors

(2014) Cyril Zipfel   TRENDS IN IMMUNOLOGY

The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

(2014) Kee Hoon Sohn et al.   PLoS Genetics

NLR-Associating Transcription Factor bHLH84 and Its Paralogs Function Redundantly in Plant Immunity

(2014) Fang Xu et al.   PLoS Pathogens

A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis

(2014) Stella Cesari et al.   Frontiers in Plant Science

Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity

(2013) Stephan Wagner et al.   Cell Host & Microbe

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

(2013) A. Marijke Keestra et al.   NATURE

The Rice Resistance Protein Pair RGA4/RGA5 Recognizes the Magnaporthe oryzae Effectors AVR-Pia and AVR1-CO39 by Direct Binding

(2013) S. Cesari et al.   PLANT CELL

Barley MLA Immune Receptors Directly Interfere with Antagonistically Acting Transcription Factors to Initiate Disease Resistance Signaling

(2013) C. Chang et al.   PLANT CELL

Recognition of the Protein Kinase AVRPPHB SUSCEPTIBLE1 by the Disease Resistance Protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 Is Dependent on S-Acylation and an Exposed Loop in AVRPPHB SUSCEPTIBLE1

(2013) D. Qi et al.   PLANT PHYSIOLOGY

The Role of TIR-NBS and TIR-X Proteins in Plant Basal Defense Responses

(2013) R. S. Nandety et al.   PLANT PHYSIOLOGY

Blast resistance of CC-NB-LRR protein Pb1 is mediated by WRKY45 through protein–protein interaction

(2013) Haruhiko Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

The Gene Sr33, an Ortholog of Barley Mla Genes, Encodes Resistance to Wheat Stem Rust Race Ug99

(2013) S. Periyannan et al.   SCIENCE

Genetic Requirements for Signaling from an Autoactive Plant NB-LRR Intracellular Innate Immune Receptor

(2013) Melinda Roberts et al.   PLoS Genetics

Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity

(2013) Meenu S. Padmanabhan et al.   PLoS Pathogens

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

A new eye on NLR proteins: focused on clarity or diffused by complexity?

(2012) Vera Bonardi et al.   CURRENT OPINION IN IMMUNOLOGY

How to build a pathogen detector: structural basis of NB-LRR function

(2012) Frank LW Takken et al.   CURRENT OPINION IN PLANT BIOLOGY

Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

(2012) Kuo-Chieh Liao et al.   INFECTION AND IMMUNITY

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

(2012) Els F. Halff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Complex NOD-Like Receptor Repertoire of the Coral Acropora digitifera Includes Novel Domain Combinations

(2012) Mayuko Hamada et al.   MOLECULAR BIOLOGY AND EVOLUTION

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Mice, men and the relatives: cross-species studies underpin innate immunity

(2012) C. E. Bryant et al.   Open Biology

Molecular Determinants of Resistance Activation and Suppression by Phytophthora infestans Effector IPI-O

(2012) Yu Chen et al.   PLoS Pathogens

Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance

(2012) Shiwei Bai et al.   PLoS Pathogens

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death

(2011) Takaki Maekawa et al.   Cell Host & Microbe

New insights in plant immunity signaling activation

(2011) Maud Bernoux et al.   CURRENT OPINION IN PLANT BIOLOGY

Plant NB-LRR signaling: upstreams and downstreams

(2011) James Mitch Elmore et al.   CURRENT OPINION IN PLANT BIOLOGY

l-Ala-γ-d-Glu-meso-diaminopimelic Acid (DAP) Interacts Directly with Leucine-rich Region Domain of Nucleotide-binding Oligomerization Domain 1, Increasing Phosphorylation Activity of Receptor-interacting Serine/Threonine-protein Kinase 2 and Its Interaction with Nucleotide-binding Oligomerization Domain 1

(2011) Hamed Laroui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP

(2011) Simon J. Williams et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Cell Death Mediated by the N-Terminal Domains of a Unique and Highly Conserved Class of NB-LRR Protein

(2011) Sarah M. Collier et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

NLR functions in plant and animal immune systems: so far and yet so close

(2011) Takaki Maekawa et al.   NATURE IMMUNOLOGY

Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes

(2011) Jia-Xing Yue et al.   NEW PHYTOLOGIST

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

(2011) V. Bonardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arabidopsis EDS1 Connects Pathogen Effector Recognition to Cell Compartment-Specific Immune Responses

(2011) K. Heidrich et al.   SCIENCE

Pathogen Effectors Target Arabidopsis EDS1 and Alter Its Interactions with Immune Regulators

(2011) S. Bhattacharjee et al.   SCIENCE

Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

(2011) M. S. Mukhtar et al.   SCIENCE

NB-LRR proteins: pairs, pieces, perception, partners, and pathways

(2010) Timothy K Eitas et al.   CURRENT OPINION IN PLANT BIOLOGY

Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector

(2010) K. V. Krasileva et al.   PLANT CELL

A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis

(2010) Haibian Yang et al.   PLANT JOURNAL

Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor

(2010) Z. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TIR Domain of TIR-NB-LRR Resistance Proteins Is a Signaling Domain Involved in Cell Death Induction

(2009) Michal R. Swiderski et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

RRS1andRPS4provide a dualResistance-gene system against fungal and bacterial pathogens

(2009) Mari Narusaka et al.   PLANT JOURNAL

Loss of Function of a Proline-Containing Protein Confers Durable Disease Resistance in Rice

(2009) S. Fukuoka et al.   SCIENCE

Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins

(2009) Olivier Danot et al.   STRUCTURE

Plant NB-LRR Immune Receptors: From Recognition to Transcriptional Reprogramming

(2008) Jeffrey Caplan et al.   Cell Host & Microbe

Structures of TLR–ligand complexes

(2008) Mi Sun Jin et al.   CURRENT OPINION IN IMMUNOLOGY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

(2008) R. A.L. van der Hoorn et al.   PLANT CELL

RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens

(2008) Jens Staal et al.   PLANT JOURNAL

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domains

(2008) R. Brueggeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA