Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S] cluster fusion on ISCA1–ISCA2 by electron flow from ferredoxin FDX2

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

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Mammalian iron–sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins

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Structure and electrochemistry of proteins harboring iron-sulfur clusters of different nuclearities. Part IV. Canonical, non-canonical and hybrid iron-sulfur proteins

(2019) Piero Zanello   JOURNAL OF STRUCTURAL BIOLOGY

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

(2019) Sylvain Gervason et al.   Nature Communications

A pathway for assembling [4Fe‐4S] 2+ clusters in mitochondrial iron–sulfur protein biogenesis

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Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery

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Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion

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Correction to: Roles and maturation of iron–sulfur proteins in plastids

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Iron–sulfur cluster biosynthesis and trafficking – impact on human disease conditions

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Protein networks in the maturation of human iron–sulfur proteins

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IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex

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Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex

(2017) Christine Wachnowsky et al.   FEBS Journal

Iron–sulfur cluster biogenesis and trafficking in mitochondria

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ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

(2017) Lena Kristina Beilschmidt et al.   Nature Communications

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex

(2017) Michal T. Boniecki et al.   Nature Communications

Structural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis

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Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

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Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

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Genetic approaches of the Fe–S cluster biogenesis process in bacteria: Historical account, methodological aspects and future challenges

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The roles of glutaredoxins ligating Fe–S clusters: Sensing, transfer or repair functions?

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Mössbauer spectroscopy of Fe/S proteins

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Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

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Fe/S protein assembly gene IBA57 mutation causes hereditary spastic paraplegia

(2015) A. Lossos et al.   NEUROLOGY

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

The competition between chemistry and biology in assembling iron–sulfur derivatives. Molecular structures and electrochemistry. Part II. {[Fe2S2](SγCys)4} proteins

(2014) Piero Zanello   COORDINATION CHEMISTRY REVIEWS

ISCA2mutation causes infantile neurodegenerative mitochondrial disorder

(2014) Zuhair N Al-Hassnan et al.   JOURNAL OF MEDICAL GENETICS

Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery

(2014) Diego Brancaccio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[2Fe-2S] cluster transfer in iron-sulfur protein biogenesis

(2014) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

(2014) Holger Webert et al.   Nature Communications

The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron

(2013) Elisabeth M. Froschauer et al.   BIOCHEMICAL JOURNAL

Arabidopsis thaliana Nfu2 Accommodates [2Fe-2S] or [4Fe-4S] Clusters and Is Competent for in Vitro Maturation of Chloroplast [2Fe-2S] and [4Fe-4S] Cluster-Containing Proteins

(2013) Huanyao Gao et al.   BIOCHEMISTRY

Iron/sulfur proteins biogenesis in prokaryotes: Formation, regulation and diversity

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Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy

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Monothiol Glutaredoxins Can Bind Linear [Fe3S4]+ and [Fe4S4]2+ Clusters in Addition to [Fe2S2]2+ Clusters: Spectroscopic Characterization and Functional Implications

(2013) Bo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation

(2013) Marta A. Uzarska et al.   MOLECULAR BIOLOGY OF THE CELL

Spectroscopic and Functional Characterization of Iron–Sulfur Cluster-Bound Forms of Azotobacter vinelandiiNifIscA

(2012) Daphne T. Mapolelo et al.   BIOCHEMISTRY

Spectroscopic and Functional Characterization of Iron-Bound Forms of Azotobacter vinelandiiNifIscA

(2012) Daphne T. Mapolelo et al.   BIOCHEMISTRY

The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation

(2012) Alex D. Sheftel et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular organization, biochemical function, cellular role and evolution of NfuA, an atypical Fe-S carrier

(2012) Béatrice Py et al.   MOLECULAR MICROBIOLOGY

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

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A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

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Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis

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Structural and Functional Diversity of Glutaredoxins in Yeast

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Specialized Function of Yeast Isa1 and Isa2 Proteins in the Maturation of Mitochondrial [4Fe-4S] Proteins

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Monothiol glutaredoxin Grx5 interacts with Fe–S scaffold proteins Isa1 and Isa2 and supports Fe–S assembly and DNA integrity in mitochondria of fission yeast

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The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity

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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

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The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

(2010) A. D. Sheftel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Proposed Role for theAzotobacter vinelandiiNfuA Protein as an Intermediate Iron-Sulfur Cluster Carrier

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