Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

(2015) Akira Nakajima et al.   BEHAVIOURAL BRAIN RESEARCH

Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2

(2015) Su-Yu Chien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

(2015) Yongjian Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Challenges and the Promise of Molecular Targeted Therapy in Malignant Gliomas

(2015) Hongxiang Wang et al.   NEOPLASIA

Nobiletin Induces Inhibitions of Ras Activity and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling to Suppress Cell Proliferation in C6 Rat Glioma Cells

(2013) Koichi Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

(2013) Y. Yabuki et al.   NEUROSCIENCE

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells

(2013) Ming-Der Shi et al.   PHYTOMEDICINE

Inhibitory Effects of Nobiletin on Hepatocellular CarcinomaIn VitroandIn Vivo

(2013) Xiuying Ma et al.   PHYTOTHERAPY RESEARCH

Synergistic Anti-inflammatory Effects of Nobiletin and Sulforaphane in Lipopolysaccharide-Stimulated RAW 264.7 Cells

(2012) Shanshan Guo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice

(2012) Young-Sil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells

(2011) Roberta Castino et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

(2011) Suguru Harada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice

(2008) Shingo Miyamoto et al.   CARCINOGENESIS

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A highly invasive human glioblastoma pre-clinical model for testing therapeutics

(2008) Qian Xie et al.   Journal of Translational Medicine

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells

(2007) Yoshiki Miyata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS