Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats

(2016) Jing Yao et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype

(2014) Zunling Li et al.   BMC CANCER

Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis

(2014) Francesca Algieri et al.   Journal of Crohns & Colitis

Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients

(2014) Satya Vati Rana et al.   Journal of Crohns & Colitis

Mechanism of IL-1 -Induced Increase in Intestinal Epithelial Tight Junction Permeability

(2014) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

(2014) Tobias Piegeler et al.   BMC Anesthesiology

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Hymenaea stigonocarpa Mart. ex Hayne: A tropical medicinal plant with intestinal anti-inflammatory activity in TNBS model of intestinal inflammation in rats

(2013) Patrícia Rodrigues Orsi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mechanism of IL-1  Modulation of Intestinal Epithelial Barrier Involves p38 Kinase and Activating Transcription Factor-2 Activation

(2013) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway

(2013) Raquel Cristina Schwanke et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells

(2012) Sandra Lechowski et al.   EUROPEAN JOURNAL OF NUTRITION

Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF- B Pathway in Human Non-Small Cell Lung Cancer

(2011) L. Song et al.   CLINICAL CANCER RESEARCH

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

(2011) E. E. Mulvihill et al.   DIABETES

Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method

(2011) Sheelendra Pratap Singh et al.   FITOTERAPIA

Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model

(2011) Kai Heng Lam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Non-proteolytic house dust mite allergen, Der p 2, upregulated expression of tight junction molecule claudin-2 associated with Akt/GSK-3β/β-catenin signaling pathway

(2011) Wei-Chun Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions

(2011) Z. Bian et al.   JOURNAL OF IMMUNOLOGY

Development of High-Energy Amorphous Solid Dispersion of Nanosized Nobiletin, a Citrus Polymethoxylated Flavone, with Improved Oral Bioavailability

(2011) Satomi Onoue et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis

(2011) Micha Hoffmann et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation

(2010) Yanji Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo

(2010) Gang Luo et al.   CANCER BIOLOGY & THERAPY

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

(2010) Maren Amasheh et al.   JOURNAL OF CELL SCIENCE

Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrier

(2010) Rana Al-Sadi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets

(2010) Christopher M Scull et al.   Journal of Inflammation-London

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

(2009) Feli Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3',4'-didemethylnobiletin, derived from nobiletin

(2008) C.-S. Lai et al.   CARCINOGENESIS

Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells

(2008) Jie Liang et al.   FEBS Journal

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

(2008) M C Arrieta et al.   GUT

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-α-induced regulation of myosin light chain kinase gene activity

(2008) Dongmei Ye et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE