Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
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Title
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
Authors
Keywords
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Journal
NUCLEIC ACIDS RESEARCH
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2020-07-14
DOI
10.1093/nar/gkaa616
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Related references
Note: Only part of the references are listed.- Towards a treatment for genetic prion disease: trials and biomarkers
- (2020) Sonia M Vallabh et al. LANCET NEUROLOGY
- Evaluating drug targets through human loss-of-function genetic variation
- (2020) Eric Vallabh Minikel et al. NATURE
- Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease
- (2020) Sonia M. Vallabh et al. BMC Medicine
- Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
- (2020) Timothy Miller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-wide transcriptomics identifies an early preclinical signature of prion infection
- (2020) Silvia Sorce et al. PLoS Pathogens
- Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
- (2019) Oliver Preische et al. NATURE MEDICINE
- Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs
- (2019) Keith T. Gagnon et al. Nucleic Acid Therapeutics
- Therapeutic Antisense Oligonucleotides Are Coming of Age
- (2019) C. Frank Bennett Annual Review of Medicine
- Targeting Huntingtin Expression in Patients with Huntington’s Disease
- (2019) Sarah J. Tabrizi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development
- (2019) Sonia M. Vallabh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease
- (2019) Adam M. Staffaroni et al. JAMA Neurology
- Age at onset in genetic prion disease and the design of preventive clinical trials
- (2019) Eric Vallabh Minikel et al. NEUROLOGY
- Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry
- (2019) Eric Vallabh Minikel et al. MOLECULAR & CELLULAR PROTEOMICS
- Demyelinating polyneuropathy in goats lacking prion protein
- (2019) Fredrik S. Skedsmo et al. FASEB JOURNAL
- Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides
- (2019) Andrew G. Reidenbach et al. Biomolecules
- Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression
- (2018) Andrew Geoffrey Bourne Thompson et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias
- (2018) Samir Abu-Rumeileh et al. Alzheimers Research & Therapy
- Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis
- (2017) Lauren M Byrne et al. LANCET NEUROLOGY
- RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus
- (2017) Xue-Hai Liang et al. MOLECULAR THERAPY
- High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions
- (2017) Alessia Franceschini et al. Scientific Reports
- Evaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse Models
- (2017) Lauren R. Moore et al. Molecular Therapy-Nucleic Acids
- Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science
- (2016) Mario Nuvolone et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
- (2016) Alexander Küffer et al. NATURE
- Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases
- (2016) Mehtap Bacioglu et al. NEURON
- Quantifying prion disease penetrance using large population control cohorts
- (2016) Eric Vallabh Minikel et al. Science Translational Medicine
- Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis
- (2016) Bradley R. Groveman et al. Annals of Clinical and Translational Neurology
- Structure-based drug design identifies polythiophenes as antiprion compounds
- (2015) Uli S. Herrmann et al. Science Translational Medicine
- Dose-Response Analysis Using R
- (2015) Christian Ritz et al. PLoS One
- Mouse Models for Studying the Formation and Propagation of Prions
- (2014) Joel C. Watts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systemic Delivery of siRNA Down Regulates Brain Prion Protein and Ameliorates Neuropathology in Prion Disorder
- (2014) Sylvain Lehmann et al. PLoS One
- Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice
- (2014) Misol Ahn et al. PLoS One
- Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked
- (2014) Malin K. Sandberg et al. Nature Communications
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Drug resistance confounding prion therapeutics
- (2013) D. B. Berry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
- (2012) Karah Nazor Friberg et al. Molecular Therapy-Nucleic Acids
- Axonal prion protein is required for peripheral myelin maintenance
- (2010) Juliane Bremer et al. NATURE NEUROSCIENCE
- Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
- (2010) Bruce Pulford et al. PLoS One
- Analysis of proteome dynamics in the mouse brain
- (2010) J. C. Price et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Darwinian Evolution of Prions in Cell Culture
- (2010) J. Li et al. SCIENCE
- Generating a Prion with Bacterially Expressed Recombinant Prion Protein
- (2010) F. Wang et al. SCIENCE
- A systems approach to prion disease
- (2009) Daehee Hwang et al. Molecular Systems Biology
- Measuring prions by bioluminescence imaging
- (2009) G. Tamguney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions
- (2009) Sina Ghaemmaghami et al. PLoS Pathogens
- Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
- (2008) M. D. White et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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