Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

(2019) Sonia M. Vallabh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

­Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry

(2019) Eric Vallabh Minikel et al.   MOLECULAR & CELLULAR PROTEOMICS

Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer’s Amyloid-β Oligomers

(2018) Mikhail A. Kostylev et al.   MOLECULAR CELL

Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

(2016) Jonathan B. Baell   JOURNAL OF NATURAL PRODUCTS

Results from a phase 1 study of nusinersen (ISIS-SMNRx) in children with spinal muscular atrophy

(2016) Claudia A. Chiriboga et al.   NEUROLOGY

ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

(2014) Niels H. Skotte et al.   PLoS One

Nonspecific Prion Protein–Nucleic Acid Interactions Lead to Different Aggregates and Cytotoxic Species

(2012) Bruno Macedo et al.   BIOCHEMISTRY

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

(2012) Karah Nazor Friberg et al.   Molecular Therapy-Nucleic Acids

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

(2008) Mariana P. B. Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of drugs for treatment of prion infections of the central nervous system

(2008) C. Riemer et al.   JOURNAL OF GENERAL VIROLOGY