Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

(2019) Henrike Johanna Gothe et al.   MOLECULAR CELL

Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations

(2019) Mandeep Atwal et al.   MOLECULAR PHARMACOLOGY

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison

(2019) Ian G. Cowell et al.   MOLECULAR PHARMACOLOGY

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

(2019) William H. Gittens et al.   Nature Communications

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

(2018) Jan B Heidelberger et al.   EMBO REPORTS

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

(2018) Ka Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

(2018) Marc L Hyer et al.   NATURE MEDICINE

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links

(2017) Matthew J. Schellenberg et al.   SCIENCE

Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme

(2017) Mohit Misra et al.   STRUCTURE

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

(2016) Ka C. Lee et al.   BIOCHEMICAL PHARMACOLOGY

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2

(2016) Matthew J. Schellenberg et al.   NUCLEIC ACIDS RESEARCH

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks

(2013) Ismail Hassan Ismail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a Novel Ubiquitin-Independent Proteasome Pathway when RNA Polymerase II Encounters a Protein Roadblock

(2013) Y. Ban et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

(2013) Y. Maede et al.   MOLECULAR CANCER THERAPEUTICS

Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

(2013) Margaret Tammaro et al.   PLoS One

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

(2012) Pavel Moudry et al.   CELL CYCLE

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

(2012) Matthew J Schellenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

(2012) K. C. Lee et al.   Biology Open

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay

(2010) Ian G. Cowell et al.   MUTAGENESIS

MRE11 Function in Response to Topoisomerase Poisons Is Independent of its Function in Double-Strand Break Repair in Saccharomyces cerevisiae

(2010) Nicolle K. Hamilton et al.   PLoS One

Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

(2010) Kyoko Nakamura et al.   PLoS Genetics

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Numerical Analysis of Etoposide Induced DNA Breaks

(2009) Aida Muslimović et al.   PLoS One

The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

(2009) Iris Alchanati et al.   PLoS One

Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses

(2008) Jia-Rong Fan et al.   DNA REPAIR

Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone

(2008) Daniel J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Activating the ubiquitin family: UBA6 challenges the field

(2008) Marcus Groettrup et al.   TRENDS IN BIOCHEMICAL SCIENCES