The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
Authors
Keywords
-
Journal
MOLECULAR PHARMACOLOGY
Volume 96, Issue 5, Pages 562-572
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2019-09-13
DOI
10.1124/mol.119.117390
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations
- (2019) Mandeep Atwal et al. MOLECULAR PHARMACOLOGY
- Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes
- (2018) Ka Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
- (2018) Marc L Hyer et al. NATURE MEDICINE
- TOP2B: The First Thirty Years
- (2018) Caroline Austin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- SUMO-mediated regulation of NLRP3 modulates inflammasome activity
- (2018) Rachael Barry et al. Nature Communications
- Ubiquitin Chain Enrichment Middle-Down Mass Spectrometry (UbiChEM-MS) Reveals Cell-Cycle Dependent Formation of Lys11/Lys48 Branched Ubiquitin Chains
- (2017) Ambar S. J. B. Rana et al. JOURNAL OF PROTEOME RESEARCH
- Proteasome inhibitors in cancer therapy
- (2017) Elisabet E. Manasanch et al. Nature Reviews Clinical Oncology
- Deubiquitylating enzymes and drug discovery: emerging opportunities
- (2017) Jeanine A. Harrigan et al. NATURE REVIEWS DRUG DISCOVERY
- ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links
- (2017) Matthew J. Schellenberg et al. SCIENCE
- Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes
- (2017) Christian Setz et al. Viruses-Basel
- Drugging the undruggables: exploring the ubiquitin system for drug development
- (2016) Xiaodong Huang et al. CELL RESEARCH
- The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death
- (2016) Roslyn N. Crowder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deubiquitinase inhibition as a cancer therapeutic strategy
- (2015) Padraig D'Arcy et al. PHARMACOLOGY & THERAPEUTICS
- Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation
- (2015) Vijaya Pandey et al. Scientific Reports
- Analysis of histone modifications at human ribosomal DNA in liver cancer cell
- (2015) Feng Yu et al. Scientific Reports
- Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation
- (2015) Xingyue He et al. PLoS One
- Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
- (2014) Akihisa Onoda et al. NUCLEIC ACIDS RESEARCH
- An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation
- (2013) Yeong Sang Kim et al. CHEMISTRY & BIOLOGY
- Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation
- (2013) Swagat Ray et al. Nature Communications
- The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseases
- (2012) Veronika Seiberlich et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents
- (2012) Ian G. Cowell et al. International Journal of Environmental Research and Public Health
- Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
- (2011) Mikael Altun et al. CHEMISTRY & BIOLOGY
- Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1
- (2011) Corina M. Balut et al. FASEB JOURNAL
- Histone deacetylase inhibition redistributes topoisomerase IIb from heterochromatin to euchromatin
- (2011) Ian G. Cowell et al. Nucleus
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
- (2010) Yves Pommier et al. CHEMISTRY & BIOLOGY
- An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay
- (2010) Ian G. Cowell et al. MUTAGENESIS
- Conjugation of Human Topoisomerase 2 with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain Specificity
- (2008) M. Agostinho et al. CANCER RESEARCH
- Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses
- (2008) Jia-Rong Fan et al. DNA REPAIR
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started