Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations

Risk-benefit of dexrazoxane for preventing anthracycline-related cardiotoxicity: re-evaluating the European labeling

(2018) Peter Reichardt et al.   Future Oncology

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

(2018) Joseph A. Sparano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

(2016) Ka C. Lee et al.   BIOCHEMICAL PHARMACOLOGY

Comparative effects of doxorubicin and a doxorubicin analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on human topoisomerase IIβ activity and cardiac function in a chronic rabbit model

(2016) Nicole E. Frank et al.   INVESTIGATIONAL NEW DRUGS

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

(2016) Agnes Maillet et al.   Scientific Reports

Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity

(2015) Sae Rin Jean et al.   ACS Chemical Biology

Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules

(2015) Angelica Mariani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitoxantrone, More than Just Another Topoisomerase II Poison

(2015) Benny J. Evison et al.   MEDICINAL RESEARCH REVIEWS

Switched on with magnets

(2013) Sanjay Kumar   Nature Nanotechnology

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons

(2012) Stefanie C. Huelsenbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

(2012) Ian G. Cowell et al.   International Journal of Environmental Research and Public Health

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells

(2011) Nicole C Dubois et al.   NATURE BIOTECHNOLOGY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay

(2010) Ian G. Cowell et al.   MUTAGENESIS

NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform

(2008) Eriko Toyoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone

(2008) Daniel J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

(2008) K. E. Coldwell et al.   NUCLEIC ACIDS RESEARCH