Mitochondrial Dysfunction is a Key Pathway that Links Saturated Fat Intake to the Development and Progression of NAFLD

High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice

(2020) Run Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars

(2020) Siôn A. Parry et al.   DIABETES CARE

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

(2020) Jin Wang et al.   Lipids in Health and Disease

The influence of dietary fatty acids on liver fat content and metabolism

(2019) Leanne Hodson et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The Impact of Dairy Products in the Development of Type 2 Diabetes: Where Does the Evidence Stand in 2019?

(2019) Jing Guo et al.   Advances in Nutrition

Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects

(2019) Giuseppe Paradies et al.   Cells

Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat: a randomized trial

(2019) Fredrik Rosqvist et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

(2019) Leanne Hodson et al.   Nature Reviews Endocrinology

Protective effect of metformin against palmitate-induced hepatic cell death

(2019) Yana Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Dysfunction in the Transition from NASH to HCC

(2019) Mélissa Léveillé et al.   Metabolites

20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat–high-fructose diet

(2018) Gilles Fouret et al.   BRITISH JOURNAL OF NUTRITION

VDAC1 functions in Ca 2+ homeostasis and cell life and death in health and disease

(2018) Varda Shoshan-Barmatz et al.   CELL CALCIUM

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

Mitochondria in non-alcoholic fatty liver disease

(2018) Inês C.M. Simões et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolic effects, safety, and acceptability of very low-calorie ketogenic dietetic scheme on candidates for bariatric surgery

(2018) Vincenzo Pilone et al.   Surgery for Obesity and Related Diseases

Mechanisms by Which Dietary Fatty Acids Regulate Mitochondrial Structure-Function in Health and Disease

(2018) E Madison Sullivan et al.   Advances in Nutrition

Mitochondrial dysfunction-related lipid changes occur in non-alcoholic fatty liver disease progression

(2018) Kang-Yu Peng et al.   JOURNAL OF LIPID RESEARCH

Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes

(2017) Isabel Errazuriz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

(2017) Elisa Álvarez Hernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of dietary macronutrients on liver fat accumulation and metabolism

(2017) Siôn A Parry et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Murine diet-induced obesity remodels cardiac and liver mitochondrial phospholipid acyl chains with differential effects on respiratory enzyme activity

(2017) E. Madison Sullivan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Non-alcoholic Fatty Liver Disease in Morbidly Obese Individuals Undergoing Bariatric Surgery: Prevalence and Effect of the Pre-Bariatric Very Low Calorie Diet

(2017) Katherine J. P. Schwenger et al.   OBESITY SURGERY

Omega-3 PUFA modulate lipogenesis, ER stress, and mitochondrial dysfunction markers in NASH – Proteomic and lipidomic insight

(2017) Lívia Samara dos Reis Rodrigues Okada et al.   CLINICAL NUTRITION

Nonalcoholic Fatty Liver Disease

(2016) Fernando Bril et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Metabolic profiling of fatty liver in young and middle-aged adults: Cross-sectional and prospective analyses of the Young Finns Study

(2016) Jari E. Kaikkonen et al.   HEPATOLOGY

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

(2015) Ruth C. Meex et al.   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance

(2015) Jennifer Rieusset et al.   DIABETOLOGIA

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Current Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease

(2015) Shatha Hammad et al.   LIPIDS

Fat Quality Influences the Obesogenic Effect of High Fat Diets

(2015) Raffaella Crescenzo et al.   Nutrients

Hepatokines as a Link between Obesity and Cardiovascular Diseases

(2015) Hye Jin Yoo et al.   Diabetes & Metabolism Journal

New Evidence for the Role of Ceramide in the Development of Hepatic Insulin Resistance

(2015) Karolina Konstantynowicz-Nowicka et al.   PLoS One

Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans

(2014) Mario Kratz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein

(2014) Lucas Lindeboom et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

(2014) F. Rosqvist et al.   DIABETES

Dietary fat modifies lipid metabolism in the adipose tissue of metabolic syndrome patients

(2014) Antonio Camargo et al.   Genes and Nutrition

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

(2014) Giuseppe Paradies   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Dietary Fat and Saturated Fat Content on Liver Fat and Markers of Oxidative Stress in Overweight/Obese Men and Women under Weight-Stable Conditions

(2014) Anna Marina et al.   Nutrients

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics

(2013) João P. Monteiro et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease

(2013) Marno C. Ryan et al.   JOURNAL OF HEPATOLOGY

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

(2013) Robert A. Egnatchik et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial

(2012) Helena Bjermo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients

(2012) L. Bozzetto et al.   DIABETES CARE

Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease

(2012) Manar Aoun et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity

(2011) Rodrigo Valenzuela et al.   Food & Function

Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men

(2010) H. Sobrecases et al.   DIABETES & METABOLISM

Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2

(2010) Yong Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei

(2010) Grzegorz Chocian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets

(2008) Adam J. Chicco et al.   HYPERTENSION

Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men

(2008) Rutger W. van der Meer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

(2008) João S. Teodoro et al.   MITOCHONDRION