From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
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Title
From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
Authors
Keywords
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Journal
Molecular Neurodegeneration
Volume 15, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-06-03
DOI
10.1186/s13024-020-00373-9
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Note: Only part of the references are listed.- Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
- (2019) Youjun Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
- (2019) Joseph R. Klim et al. NATURE NEUROSCIENCE
- Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
- (2019) Ze’ev Melamed et al. NATURE NEUROSCIENCE
- RNA Dysregulation in Amyotrophic Lateral Sclerosis
- (2019) Zoe Butti et al. Frontiers in Genetics
- ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles
- (2019) Haiyan An et al. Acta Neuropathologica Communications
- Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients
- (2019) Raygene Martier et al. Molecular Therapy-Nucleic Acids
- Toward a Glutamate Hypothesis of Frontotemporal Dementia
- (2019) Alberto Benussi et al. Frontiers in Neuroscience
- Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
- (2019) Archana Prasad et al. Frontiers in Molecular Neuroscience
- Astrocytes in Neuropathologies Affecting the Frontal Cortex
- (2019) Ulla-Kaisa Peteri et al. Frontiers in Cellular Neuroscience
- Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
- (2019) David R Beers et al. LANCET NEUROLOGY
- Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology
- (2019) Silvia Pozzi et al. JOURNAL OF CLINICAL INVESTIGATION
- FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
- (2019) Lara Marrone et al. ACTA NEUROPATHOLOGICA
- The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?
- (2019) Rudolf C Hergesheimer et al. BRAIN
- Gut microbiota in ALS: possible role in pathogenesis?
- (2019) Pamela A. McCombe et al. Expert Review of Neurotherapeutics
- Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets
- (2019) Joseph R. Klim et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS
- (2019) Hannah Rostalski et al. Frontiers in Neuroscience
- Antisense Oligonucleotide Therapies for Neurodegenerative Diseases
- (2019) C. Frank Bennett et al. Annual Review of Neuroscience
- Cortico-spinal tDCS in ALS: A randomized, double-blind, sham-controlled trial
- (2019) Alberto Benussi et al. Brain Stimulation
- Potential roles of gut microbiome and metabolites in modulating ALS in mice
- (2019) Eran Blacher et al. NATURE
- Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial
- (2019) Jesus S. Mora et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
- (2019) Raygene Martier et al. Molecular Therapy-Nucleic Acids
- Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model
- (2019) Elisabeth Rossaert et al. Acta Neuropathologica Communications
- Past and Future of Neurotrophic Growth Factors Therapies in ALS: From Single Neurotrophic Growth Factor to Stem Cells and Human Platelet Lysates
- (2019) Flore Gouel et al. Frontiers in Neurology
- New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures
- (2019) Adam L. Boxer et al. Alzheimers & Dementia
- Long‐term edaravone efficacy in amyotrophic lateral sclerosis: Post‐hoc analyses of Study 19 (MCI186‐19)
- (2019) Jeremy Shefner et al. MUSCLE & NERVE
- Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis
- (2019) Marcel Naumann et al. Annals of Clinical and Translational Neurology
- CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
- (2019) Weiwei Cheng et al. NEURON
- Toxicity in ALS: TDP-43 modifiers and C9orf72
- (2019) Jessie L St. Martin et al. NEUROSCIENCE LETTERS
- ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
- (2019) Rita Mejzini et al. Frontiers in Neuroscience
- Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients
- (2018) Craig L. Bennett et al. ACTA NEUROPATHOLOGICA
- Potential Role of Gut Microbiota in ALS Pathogenesis and Possible Novel Therapeutic Strategies
- (2018) Letizia Mazzini et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
- (2018) Andrew E. Arrant et al. JOURNAL OF NEUROSCIENCE
- Riluzole, disease stage and survival in ALS
- (2018) Thanuja Dharmadasa et al. LANCET NEUROLOGY
- Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations
- (2018) Gye Sun Jeon et al. MOLECULAR NEUROBIOLOGY
- Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
- (2018) Yingxiao Shi et al. NATURE MEDICINE
- TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
- (2018) Matthew A. White et al. NATURE NEUROSCIENCE
- Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressiveSOD1ALS
- (2018) Michael Benatar et al. NEUROLOGY
- TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
- (2018) Yousra Khalfallah et al. Scientific Reports
- VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics
- (2018) Jinsy A. Andrews et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis
- (2018) Rebecca K. Sheean et al. JAMA Neurology
- Linking hnRNP Function to ALS and FTD Pathology
- (2018) Maria D. Purice et al. Frontiers in Neuroscience
- Emerging Issues in AAV-Mediated In Vivo Gene Therapy
- (2018) Pasqualina Colella et al. Molecular Therapy-Methods & Clinical Development
- Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis
- (2018) Ki-Wook Oh et al. ANNALS OF NEUROLOGY
- A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration
- (2018) Daniel A Solomon et al. BRAIN
- Treatment of Primary Progressive Aphasias by Transcranial Direct Current Stimulation Combined with Language Training
- (2018) Maria Cotelli et al. JOURNAL OF ALZHEIMERS DISEASE
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- (2018) Steve Vucic JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
- (2018) Patrick Oeckl et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
- (2018) Manoj Kumar Jaiswal MEDICINAL RESEARCH REVIEWS
- C9orf72-mediated ALS and FTD: multiple pathways to disease
- (2018) Rubika Balendra et al. Nature Reviews Neurology
- Inflammation in ALS/FTD pathogenesis
- (2018) Madelyn E. McCauley et al. ACTA NEUROPATHOLOGICA
- Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology
- (2018) Alissa L. Nana et al. ACTA NEUROPATHOLOGICA
- Effects of cannabinoids in Amyotrophic Lateral Sclerosis (ALS) murine models: a systematic review and meta-analysis
- (2018) Berzenn Urbi et al. JOURNAL OF NEUROCHEMISTRY
- Disease-modifying effects of metabolic perturbations in ALS/FTLD
- (2018) Ali Jawaid et al. Molecular Neurodegeneration
- Amyotrophic lateral sclerosis — a multisystem neurodegenerative disorder
- (2018) Murray Grossman Nature Reviews Neurology
- Review: Neuropathology of non-tau frontotemporal lobar degeneration
- (2018) M. Neumann et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Review: Modelling the pathology and behaviour of frontotemporal dementia
- (2018) D. A. Solomon et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis
- (2018) Katherine S. Yanagi et al. NEUROSCIENCE
- Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila
- (2018) Marine Pons et al. Acta Neuropathologica Communications
- Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice
- (2018) Krista J. Spiller et al. NEUROBIOLOGY OF DISEASE
- Metals and neurodegenerative diseases. A systematic review
- (2017) Calogero Edoardo Cicero et al. ENVIRONMENTAL RESEARCH
- Recent advances in the molecular genetics of frontotemporal lobar degeneration
- (2017) Innocenzo Rainero FUNCTIONAL NEUROLOGY
- The Microbiome-Gut-Brain Axis in Health and Disease
- (2017) Timothy G. Dinan et al. GASTROENTEROLOGY CLINICS OF NORTH AMERICA
- RNA-binding proteins in neurodegeneration: mechanisms in aggregate
- (2017) Erin G. Conlon et al. GENES & DEVELOPMENT
- Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
- (2017) Zhang-Yu Zou et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle
- (2017) Darren T. Hwee et al. JOURNAL OF PHYSIOLOGY-LONDON
- Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
- (2017) Koji Abe et al. LANCET NEUROLOGY
- Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2017) Vincent Meininger et al. LANCET NEUROLOGY
- CK-2127107 amplifies skeletal muscle response to nerve activation in humans
- (2017) Jinsy A. Andrews et al. MUSCLE & NERVE
- Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
- (2017) Lindsay A. Becker et al. NATURE
- Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN , TMEM106B , ABCC9 , and KCNMB2
- (2017) Yuriko Katsumata et al. NEUROBIOLOGY OF AGING
- Frontotemporal Dementia
- (2017) Nicholas T. Olney et al. NEUROLOGIC CLINICS
- Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases
- (2017) Kathleen M. Schoch et al. NEURON
- Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells
- (2017) Chiara Appocher et al. NUCLEIC ACIDS RESEARCH
- Clinical features of amyotrophic lateral sclerosis and their prognostic value
- (2017) C. Tard et al. REVUE NEUROLOGIQUE
- Pathology of Neurodegenerative Diseases
- (2017) Brittany N. Dugger et al. Cold Spring Harbor Perspectives in Biology
- Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
- (2017) Kahina Hammam et al. Nature Communications
- Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
- (2017) Ping Wang et al. Nature Communications
- Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
- (2017) Jung-A. A. Woo et al. Nature Communications
- Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target
- (2017) B. Borroni et al. Scientific Reports
- Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
- (2017) Charles C. White et al. PLOS MEDICINE
- Edaravone and its clinical development for amyotrophic lateral sclerosis
- (2017) Koji Takei et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials
- (2017) Syed I. Khalid et al. Frontiers in Neurology
- Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes
- (2017) Herve Rhinn et al. Cell Systems
- ALS and FTD: an epigenetic perspective
- (2016) Veronique V. Belzil et al. ACTA NEUROPATHOLOGICA
- Gut Microbiota-brain Axis
- (2016) Hong-Xing Wang et al. CHINESE MEDICAL JOURNAL
- Genetics of Frontotemporal Dementia
- (2016) Diana A. Olszewska et al. Current Neurology and Neuroscience Reports
- Mechanistic Insights into Hsp104 Potentiation
- (2016) Mariana P. Torrente et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies
- (2016) Roberta Cascella et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The clinical spectrum of sporadic and familial forms of frontotemporal dementia
- (2016) Ione O. C. Woollacott et al. JOURNAL OF NEUROCHEMISTRY
- Frontotemporal dementia: from molecular mechanisms to therapy
- (2016) Christian Haass et al. JOURNAL OF NEUROCHEMISTRY
- Genetics of FTLD: overview and what else we can expect from genetic studies
- (2016) Cyril Pottier et al. JOURNAL OF NEUROCHEMISTRY
- Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders
- (2016) Maria Sara Cipolat Mis et al. MOLECULAR NEUROBIOLOGY
- Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy
- (2016) Shunsuke Koga et al. MOVEMENT DISORDERS
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
- (2016) Emanuela Mazzon et al. Neural Regeneration Research
- Transplantation of spinal cord–derived neural stem cells for ALS
- (2016) Jonathan D. Glass et al. NEUROLOGY
- Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS
- (2016) Nathan P. Staff et al. NEUROLOGY
- CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
- (2016) Kelly L. Williams et al. Nature Communications
- Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis
- (2016) Jeri W. Nieves et al. JAMA Neurology
- Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis
- (2016) Panayiota Petrou et al. JAMA Neurology
- Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C
- (2016) A. Dardis et al. Acta Neuropathologica Communications
- Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients
- (2016) Gamze Guven et al. PLoS One
- Molecular basis of ALS and FTD: implications for translational studies / Molekularna osnova ALS-a i FTD-a: implikacije za translacijska istraživanja
- (2015) Rajka M. Liščić Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology
- ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons
- (2015) J. Lenzi et al. Disease Models & Mechanisms
- Motor neuron disease-frontotemporal dementia: a clinical continuum
- (2015) Emma Devenney et al. Expert Review of Neurotherapeutics
- TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor
- (2015) Fatemeh Mohagheghi et al. HUMAN MOLECULAR GENETICS
- C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
- (2015) Jonathan D Rohrer et al. LANCET NEUROLOGY
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
- (2015) Brian D. Freibaum et al. NATURE
- Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- (2015) Ana Jovičić et al. NATURE NEUROSCIENCE
- Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion
- (2015) Pietro Fratta et al. NEUROBIOLOGY OF AGING
- Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants
- (2015) Shahram Saberi et al. NEUROLOGIC CLINICS
- Loss ofTBK1is a frequent cause of frontotemporal dementia in a Belgian cohort
- (2015) Ilse Gijselinck et al. NEUROLOGY
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
- (2015) Tetsuro Murakami et al. NEURON
- TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
- (2015) Emma L. Scotter et al. Neurotherapeutics
- TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
- (2015) Laura De Conti et al. NUCLEIC ACIDS RESEARCH
- The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia
- (2015) Rowan A. Radford et al. Frontiers in Cellular Neuroscience
- TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III
- (2015) Mi-Hee Jun et al. Molecular Brain
- Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis
- (2015) Ki-Wook Oh et al. Stem Cells Translational Medicine
- Motor neuron disease-frontotemporal dementia: a clinical continuum
- (2015) Emma Devenney et al. Expert Review of Neurotherapeutics
- Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis
- (2015) Marianthi-Anna Kioumourtzoglou et al. JAMA Neurology
- Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
- (2015) Katja Hochgräfe et al. Acta Neuropathologica Communications
- Ozanezumab Dose Selection for Amyotrophic Lateral Sclerosis by Pharmacokinetic-Pharmacodynamic Modelling of Immunohistochemistry Data from Patient Muscle Biopsies
- (2015) Alienor Berges et al. PLoS One
- Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
- (2014) Julie van der Zee et al. ACTA NEUROPATHOLOGICA
- TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
- (2014) Michael D. Gallagher et al. ACTA NEUROPATHOLOGICA
- Frontotemporal dementia: a bridge between dementia and neuromuscular disease
- (2014) Adeline S.L. Ng et al. Annals of the New York Academy of Sciences
- C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia
- (2014) Sarah Mizielinska et al. CURRENT OPINION IN NEUROLOGY
- Tirasemtiv (CK-2017357)
- (2014) M. Romano DRUGS OF THE FUTURE
- High-calorie diets in amyotrophic lateral sclerosis
- (2014) Ammar Al-Chalabi LANCET
- Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
- (2014) Merit E Cudkowicz et al. LANCET NEUROLOGY
- Antisense Oligonucleotide Therapy for the Treatment of C9ORF72 ALS/FTD Diseases
- (2014) Giulietta Riboldi et al. MOLECULAR NEUROBIOLOGY
- Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
- (2014) Marka van Blitterswijk et al. Molecular Neurodegeneration
- Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
- (2014) Janel O Johnson et al. NATURE NEUROSCIENCE
- Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
- (2014) Bradley N. Smith et al. NEURON
- Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells
- (2014) Agnes L. Nishimura et al. PLoS One
- Ceftriaxone Preserves Glutamate Transporters and Prevents Intermittent Hypoxia-Induced Vulnerability to Brain Excitotoxic Injury
- (2014) Rekha Jagadapillai et al. PLoS One
- Frontotemporal Lobar Degeneration: A Clinical Approach
- (2014) Elissaios Karageorgiou et al. SEMINARS IN NEUROLOGY
- The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43
- (2014) Nicole F. Liachko et al. PLoS Genetics
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation
- (2013) Masaki Kamada et al. NEUROPATHOLOGY
- GeneMANIA Prediction Server 2013 Update
- (2013) Khalid Zuberi et al. NUCLEIC ACIDS RESEARCH
- The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol
- (2013) Bernadett Kalmar et al. PHARMACOLOGY & THERAPEUTICS
- Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review
- (2013) Xiao-dong Pan et al. Translational Neurodegeneration
- Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
- (2012) Glenda Halliday et al. ACTA NEUROPATHOLOGICA
- Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development
- (2012) Adam L. Boxer et al. Alzheimers & Dementia
- Progranulin: An emerging target for FTLD therapies
- (2012) Jennifer Gass et al. BRAIN RESEARCH
- The role of Nogo-A in axonal plasticity, regrowth and repair
- (2012) Vincent Pernet et al. CELL AND TISSUE RESEARCH
- TLS/FUS
- (2012) Adelene Y. Tan et al. CELL CYCLE
- Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
- (2012) Jenny S. Henkel et al. EMBO Molecular Medicine
- Progranulin regulates neuronal outgrowth independent of Sortilin
- (2012) Jennifer Gass et al. Molecular Neurodegeneration
- Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation
- (2012) J. Kirby et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
- (2012) M. Prudencio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements
- (2012) A. Y. Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association of TMEM106B Gene Polymorphism With Age at Onset in Granulin Mutation Carriers and Plasma Granulin Protein Levels
- (2011) Carlos Cruchaga et al. ARCHIVES OF NEUROLOGY
- FTD and ALS: A Tale of Two Diseases
- (2011) R. Ferrari et al. Current Alzheimer Research
- Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways
- (2011) Vivek Swarup et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
- (2011) Laura Ferraiuolo et al. Nature Reviews Neurology
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
- (2011) Edward B. Lee et al. NATURE REVIEWS NEUROSCIENCE
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
- (2010) Ryan Vass et al. ACTA NEUROPATHOLOGICA
- Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma
- (2010) Minerva M. Carrasquillo et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS
- (2010) Ali Jawaid et al. Amyotrophic Lateral Sclerosis
- Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis
- (2010) B.C. Cheah et al. CURRENT MEDICINAL CHEMISTRY
- Does apolipoprotein E genotype modify the clinical expression of ALS?
- (2010) A. Jawaid et al. EUROPEAN JOURNAL OF NEUROLOGY
- ALS disease onset may occur later in patients with pre-morbid diabetes mellitus
- (2010) A. Jawaid et al. EUROPEAN JOURNAL OF NEUROLOGY
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
- (2010) Andrew C. Elden et al. NATURE
- Genetic contribution of FUS to frontotemporal lobar degeneration
- (2010) T. Van Langenhove et al. NEUROLOGY
- TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers
- (2010) N. Finch et al. NEUROLOGY
- Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
- (2010) Fenghua Hu et al. NEURON
- Ameliorating Amyotrophic Lateral Sclerosis
- (2010) Lewis P. Rowland NEW ENGLAND JOURNAL OF MEDICINE
- The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
- (2010) David Warde-Farley et al. NUCLEIC ACIDS RESEARCH
- Non-ATG-initiated translation directed by microsatellite expansions
- (2010) T. Zu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular basis of amyotrophic lateral sclerosis
- (2010) Rajka M. Liscic et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
- (2009) Michael J. Strong et al. Amyotrophic Lateral Sclerosis
- Rethinking ALS: The FUS about TDP-43
- (2009) Clotilde Lagier-Tourenne et al. CELL
- Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial
- (2009) L. Mazzini et al. EXPERIMENTAL NEUROLOGY
- Mutation withinTARDBPleads to Frontotemporal Dementia without motor neuron disease
- (2009) B. Borroni et al. HUMAN MUTATION
- Hypermetabolism in ALS patients: an early and persistent phenomenon
- (2009) C. Bouteloup et al. JOURNAL OF NEUROLOGY
- Incidence of amyotrophic lateral sclerosis in Europe
- (2009) G. Logroscino et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases
- (2008) Wen-Lang Lin et al. ACTA NEUROPATHOLOGICA
- The Endocannabinoid System in Amyotrophic Lateral Sclerosis
- (2008) Lynsey Bilsland et al. CURRENT PHARMACEUTICAL DESIGN
- ALS and FTLD: two faces of TDP-43 proteinopathy
- (2008) R. M. Liscic et al. EUROPEAN JOURNAL OF NEUROLOGY
- Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies
- (2008) Kunihiro Uryu et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Nuclear TAR DNA Binding Protein 43 Expression in Spinal Cord Neurons Correlates With the Clinical Course in Amyotrophic Lateral Sclerosis
- (2008) Hisae Sumi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
- (2008) Vivianna M Van Deerlin et al. LANCET NEUROLOGY
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- Incidence of early-onset dementias in Cambridgeshire, United Kingdom
- (2008) L. Mercy et al. NEUROLOGY
- Pallidonigral TDP-43 pathology in Perry syndrome
- (2008) Christian Wider et al. PARKINSONISM & RELATED DISORDERS
- Nutrition and Dietary Supplements in Motor Neuron Disease
- (2008) Jeffrey Rosenfeld et al. Physical Medicine and Rehabilitation Clinics of North America
- Novel roles for Nogo receptor in inflammation and disease
- (2008) Samuel David et al. TRENDS IN NEUROSCIENCES
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