Past and Future of Neurotrophic Growth Factors Therapies in ALS: From Single Neurotrophic Growth Factor to Stem Cells and Human Platelet Lysates

Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?

(2019) Agnese Gugliandolo et al.   Stem Cells International

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

(2019) David R Beers et al.   LANCET NEUROLOGY

Systemic administration of scAAV9-IGF1 extends survival in SOD1 G93A ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway

(2018) Wan Wang et al.   BRAIN RESEARCH BULLETIN

The biology of the platelet with special reference to inflammation wound healing and immunity

(2018) Alan T Nurden   Frontiers in Bioscience-Landmark

Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis

(2018) Gretchen M. Thomsen et al.   STEM CELLS

Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis

(2018) Ki-Wook Oh et al.   ANNALS OF NEUROLOGY

Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects

(2017) G M Thomsen et al.   GENE THERAPY

Stem cells for ALS: An overview of possible therapeutic approaches

(2017) Joanna Czarzasta et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway

(2016) Ying Wang et al.   BRAIN RESEARCH

Disruption of the astrocytic TNFR1-GDNF axis accelerates motor neuron degeneration and disease progression in amyotrophic lateral sclerosis

(2016) Liliana Brambilla et al.   HUMAN MOLECULAR GENETICS

The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways

(2016) Flore Gouel et al.   Journal of Tissue Engineering and Regenerative Medicine

Tandem Delivery of Multiple Therapeutic Genes Using Umbilical Cord Blood Cells Improves Symptomatic Outcomes in ALS

(2016) Rustem Robertovich Islamov et al.   MOLECULAR NEUROBIOLOGY

Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1G93A ALS Mouse Model via Upregulation of D-Amino Acid Oxidase

(2016) HuiQian Lin et al.   MOLECULAR NEUROBIOLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Granulocyte Colony-Stimulating Factor Ameliorates Skeletal Muscle Dysfunction in Amyotrophic Lateral Sclerosis Mice and Improves Proliferation of SOD1-G93A Myoblasts in vitro

(2016) Amaya Rando et al.   Neurodegenerative Diseases

Breathing pattern in a phase I clinical trial of intraspinal injection of autologous bone marrow mononuclear cells in patients with amyotrophic lateral sclerosis

(2016) Francisco José Ruiz-López et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke

(2015) Ying Zhang et al.   BRAIN RESEARCH

Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule

(2015) Rustem Islamov et al.   CURRENT GENE THERAPY

Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-κB-dependent inflammation process in a mouse model of Parkinson's disease

(2015) Eduardo Anitua et al.   JOURNAL OF CONTROLLED RELEASE

Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors

(2015) Sarah Knippenberg et al.   Journal of Tissue Engineering and Regenerative Medicine

Human neural stem cell transplantation in ALS: initial results from a phase I trial

(2015) Letizia Mazzini et al.   Journal of Translational Medicine

Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis

(2014) Marina Boido et al.   CYTOTHERAPY

Plasma rich in growth factors (PRGF-Endoret) reduces neuropathologic hallmarks and improves cognitive functions in an Alzheimer's disease mouse model

(2014) Eduardo Anitua et al.   NEUROBIOLOGY OF AGING

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

(2014) Orhan Tansel Korkmaz et al.   NEUROSCIENCE LETTERS

Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis

(2014) Christina M Lewis et al.   Stem Cell Research & Therapy

Blood-derived biomaterials and platelet growth factors in regenerative medicine

(2013) Thierry Burnouf et al.   BLOOD REVIEWS

Transplantation of Human Adipose Tissue-Derived Stem Cells Delays Clinical Onset and Prolongs Life Span in ALS Mouse Model

(2013) Kwang S. Kim et al.   CELL TRANSPLANTATION

Acute and chronic MRI changes in the spine and spinal cord after surgical stem cell grafting in patients with definite amyotrophic lateral sclerosis: Post-infusion injuries are unrelated with clinical impairment

(2013) José M. García Santos et al.   MAGNETIC RESONANCE IMAGING

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

(2013) Dan Krakora et al.   MOLECULAR THERAPY

Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model

(2013) S. Marconi et al.   NEUROSCIENCE

Bone Marrow Transplantation in Hindlimb Muscles of Motoneuron Degenerative Mice Reduces Neuronal Death and Improves Motor Function

(2013) Diego Pastor et al.   STEM CELLS AND DEVELOPMENT

Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke

(2013) Yael Hayon et al.   THROMBOSIS AND HAEMOSTASIS

Delayed Administration of VEGF Rescues Spinal Motor Neurons from Death with a Short Effective Time Frame in Excitotoxic Experimental Models in Vivo

(2012) Luis B Tovar-y-Romo et al.   ASN Neuro

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(2012) Antonio Uccelli et al.   MOLECULAR MEDICINE

Intraspinal Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

(2012) Jonathan Riley et al.   NEUROSURGERY

Multiple Intravenous Administrations of Human Umbilical Cord Blood Cells Benefit in a Mouse Model of ALS

(2012) Svitlana Garbuzova-Davis et al.   PLoS One

Deletion of the BDNF Truncated Receptor TrkB.T1 Delays Disease Onset in a Mouse Model of Amyotrophic Lateral Sclerosis

(2012) Sudhirkumar U. Yanpallewar et al.   PLoS One

Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

(2012) Miguel Blanquer et al.   STEM CELLS

Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients

(2012) Jonathan D. Glass et al.   STEM CELLS

Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice

(2011) Albert A Rizvanov et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intraspinal Injection of Human Umbilical Cord Blood-Derived Cells Is Neuroprotective in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2011) Sarah Knippenberg et al.   Neurodegenerative Diseases

Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule

(2011) Ana C Calvo et al.   Orphanet Journal of Rare Diseases

Intracerebroventricular Administration of Human Umbilical Cord Blood Cells Delays Disease Progression in Two Murine Models of Motor Neuron Degeneration

(2011) P. Bigini et al.   REJUVENATION RESEARCH

Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research

(2011) Kristien Reekmans et al.   Stem Cell Reviews and Reports

Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

(2011) Diego Pastor et al.   Stem Cell Reviews and Reports

Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study

(2010) Beatrice Nefussy et al.   Amyotrophic Lateral Sclerosis

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

(2010) James C Dodge et al.   MOLECULAR THERAPY

CNS-targeted Viral Delivery of G-CSF in an Animal Model for ALS: Improved Efficacy and Preservation of the Neuromuscular Unit

(2010) Alexandre Henriques et al.   MOLECULAR THERAPY

Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis

(2009) Yuanjin Zhang et al.   Amyotrophic Lateral Sclerosis

Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

(2009) D H Hwang et al.   GENE THERAPY

Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry

(2009) Leyan Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain

(2009) Patricia Mathieu et al.   JOURNAL OF NEUROCHEMISTRY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis

(2008) Claudia Pitzer et al.   BRAIN

Platelets and wound healing

(2008) Alan et al.   Frontiers in Bioscience-Landmark

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

(2008) Masatoshi Suzuki et al.   MOLECULAR THERAPY

Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity

(2008) James C Dodge et al.   MOLECULAR THERAPY

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

Human umbilical cord blood cells transfected with VEGF and L1CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis—a novel approach in stem cell therapy

(2008) Albert A. Rizvanov et al.   NEUROCHEMISTRY INTERNATIONAL

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

(2008) E. J. Sorenson et al.   NEUROLOGY