期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 108, 期 1, 页码 297-308出版社
OXFORD UNIV PRESS
DOI: 10.1002/JLB.1MIR0420-076R
关键词
atherosclerosis; cancer; monocytes; T cells
资金
- National Institutes of Health [R01 CA202987, R01 HL134236, P01 HL136275, U01 CA224766, T32 AI125279-01, F32 HL146069-01A1]
- AHA [19POST34450020]
Monocytes and monocyte-derived cells, including M phi s and dendritic cells, exhibit a diverse array of phenotypic states that are dictated by their surrounding microenvironment. These cells direct T cell activation and function via cues that range from being immunosuppressive to immunostimulatory. Solid tumors and atherosclerotic plaques represent two pathological niches with distinct immune microenvironments. While monocytes and their progeny possess a phenotypic spectrum found within both disease contexts, most within tumors are pro-tumoral and support evasion of host immune responses by tumor cells. In contrast, monocyte-derived cells within atherosclerotic plaques are usually pro-atherogenic, pro-inflammatory, and predominantly directed against self-antigens. Consequently, cancer immunotherapies strive to enhance the immune response against tumor antigens, whereas atherosclerosis treatments seek to dampen the immune response against lipid antigens. Insights into monocyte-T cell interactions within these niches could thus inform therapeutic strategies for two immunologically distinct diseases. Here, we review monocyte diversity, interactions between monocytes and T cells within tumor and plaque microenvironments, how certain therapies have leveraged these interactions, and novel strategies to assay such associations.
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