Targeting NLRP3 and staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

(2020) Xiaogang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release

(2019) Maryam Rashidi et al.   JOURNAL OF IMMUNOLOGY

Complementing the Cancer-Immunity Cycle

(2019) Ruben Pio et al.   Frontiers in Immunology

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

(2018) Taylor S. Cohen et al.   Cell Reports

Methicillin-resistant Staphylococcus aureus

(2018) Andie S. Lee et al.   Nature Reviews Disease Primers

Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin

(2018) Angelino T. Tromp et al.   Nature Microbiology

IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms

(2018) Sílvia Pires et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

(2018) James E. Vince et al.   Cell Reports

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

(2017) András N. Spaan et al.   NATURE REVIEWS MICROBIOLOGY

Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity

(2017) E. Sachiko Seilie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

(2017) Amy T. Y. Yeung et al.   Nature Communications

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB -Independent Tissue-Resident Macrophages

(2017) Julian Buchrieser et al.   Stem Cell Reports

Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way

(2016) Bo Shopsin et al.   Cell Host & Microbe

IVIG-mediated protection against necrotizing pneumonia caused by MRSA

(2016) Binh An Diep et al.   Science Translational Medicine

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

(2016) Taylor S. Cohen et al.   Science Translational Medicine

Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc

(2016) Divya Balasubramanian et al.   mBio

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling

(2016) Kipyegon Kitur et al.   Cell Reports

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

(2016) Mary Speir et al.   Nature Microbiology

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse

(2015) Christian M. Karsten et al.   JOURNAL OF IMMUNOLOGY

Differential Interaction of the Staphylococcal Toxins Panton–Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors

(2015) András N. Spaan et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

(2015) Kaur Alasoo et al.   Scientific Reports

Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection

(2015) Ching Wen Tseng et al.   PLoS Pathogens

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

(2015) Jason H. Melehani et al.   PLoS Pathogens

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

(2015) Nico Lachmann et al.   Stem Cell Reports

Induced Pluripotent Stem Cell Derived Macrophages as a Cellular System to Study Salmonella and Other Pathogens

(2015) Christine Hale et al.   PLoS One

Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins ofStaphylococcus aureuswith a single human monoclonal antibody

(2014) Harald Rouha et al.   mAbs

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Kineret®/IL-1ra Blocks the IL-1/IL-8 Inflammatory Cascade during Recombinant Panton Valentine Leukocidin-Triggered Pneumonia but Not during S. aureus Infection

(2014) Delphine Labrousse et al.   PLoS One

The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors

(2013) András N. Spaan et al.   Cell Host & Microbe

Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1

(2013) A. L. DuMont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner

(2012) Magali Perret et al.   CELLULAR MICROBIOLOGY

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome

(2012) Dirk Holzinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comparative Analysis of USA300 Virulence Determinants in a Rabbit Model of Skin and Soft Tissue Infection

(2011) Scott D. Kobayashi et al.   JOURNAL OF INFECTIOUS DISEASES

Panton-Valentine Leukocidin Does Play a Role in the Early Stage of Staphylococcus aureus Skin Infections: A Rabbit Model

(2011) Urszula Lipinska et al.   PLoS One

Rapid Detection of Staphylococcus aureus Panton-Valentine Leukocidin in Clinical Specimens by Enzyme-Linked Immunosorbent Assay and Immunochromatographic Tests

(2010) C. Badiou et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The Panton‐Valentine Leukocidin Is a Virulence Factor in a Murine Model of Necrotizing Pneumonia

(2010) François Vandenesch et al.   JOURNAL OF INFECTIOUS DISEASES

Community-associated meticillin-resistant Staphylococcus aureus

(2010) Frank R DeLeo et al.   LANCET

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury

(2010) B. A. Diep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Panton‐Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community‐Associated Methicillin‐ResistantStaphylococcus aureusDisease

(2008) Juliane Bubeck Wardenburg et al.   JOURNAL OF INFECTIOUS DISEASES