A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

The impact of the COVID ‐19 pandemic on patients with chronic plaque psoriasis being treated with biological therapy: the Northern Italy experience

(2020) P. Gisondi et al.   BRITISH JOURNAL OF DERMATOLOGY

Autopsy in suspected COVID-19 cases

(2020) Brian Hanley et al.   JOURNAL OF CLINICAL PATHOLOGY

COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal

(2020) Hasan K. Siddiqi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs

(2020) A. Conti et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

SARS‐CoV‐2 infection in a psoriatic patient treated with IL‐17 inhibitor

(2020) R. Balestri et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

SARS-CoV-2 infection in a psoriatic patient treated with IL-23 inhibitor

(2020) F. Messina et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

(2020) Pavan K. Bhatraju et al.   NEW ENGLAND JOURNAL OF MEDICINE

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

The protective and pathogenic roles of IL-17 in viral infections: friend or foe?

(2019) Wen-Tao Ma et al.   Open Biology

A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

(2019) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus

(2018) Adel Abdel-Moneim et al.   BIOMEDICINE & PHARMACOTHERAPY

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

(2018) Waleed H. Mahallawi et al.   CYTOKINE

SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension

(2018) Ya-Nan Du et al.   Frontiers in Physiology

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity

(2017) Bo Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of interleukin-17A in the pathogenesis of kidney diseases

(2017) Charlotte Cortvrindt et al.   PATHOLOGY

Th17 cells are associated with protection from ventilator associated pneumonia

(2017) Marika Orlov et al.   PLoS One

Role of IL-17 in LPS-induced acute lung injury: an in vivo study

(2017) Qi Ding et al.   Oncotarget

Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome

(2016) Roshell Muir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome

(2016) Carmen Mikacenic et al.   CRITICAL CARE MEDICINE

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

(2016) Agnieszka Wasilewska et al.   Postepy Dermatologii i Alergologii

MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells

(2015) L. Ma et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort

(2015) Eliecer Coto et al.   HUMAN IMMUNOLOGY

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

(2015) John T. Li et al.   JOURNAL OF IMMUNOLOGY

Estradiol Inhibits Th17 Cell Differentiation through Inhibition ofRORγTTranscription by Recruiting the ERα/REA Complex to Estrogen Response Elements of theRORγTPromoter

(2015) Rong-Yi Chen et al.   JOURNAL OF IMMUNOLOGY

IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense

(2015) S Cai et al.   Mucosal Immunology

The role of Th17 and Treg responses in the pathogenesis of RSV infection

(2015) Thomas C. Mangodt et al.   PEDIATRIC RESEARCH

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

(2014) Tara E Sutherland et al.   NATURE IMMUNOLOGY

Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?

(2014) Emmanuel Faure et al.   PLoS One

Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients

(2014) Lucy Baldeón R. et al.   PLoS One

Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis

(2013) Zhenping Li et al.   CARDIOVASCULAR PATHOLOGY

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

(2013) Hsing-Chuan Tsai et al.   Clinical & Developmental Immunology

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

Loss of the balance between CD4+Foxp3+ regulatory T cells and CD4+IL17A+ Th17 cells in patients with type 1 diabetes

(2013) Monika Ryba-Stanisławowska et al.   HUMAN IMMUNOLOGY

Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori–infected children

(2013) C Serrano et al.   Mucosal Immunology

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis

(2012) Abdul M. Tyagi et al.   PLoS One

MicroRNA-155 Modulates Treg and Th17 Cells Differentiation and Th17 Cell Function by Targeting SOCS1

(2012) Rui Yao et al.   PLoS One

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

Estradiol impairs the Th17 immune response against Candida albicans

(2011) Miguel Relloso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes

(2011) M. Balasubramanyam et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis

(2011) Maria D. Van Kerkhove et al.   PLOS MEDICINE

Potentiation of Th17 cytokines in aging process contributes to the development of colitis

(2010) Xinshou Ouyang et al.   CELLULAR IMMUNOLOGY

IL-17 Contributes to Angiogenesis in Rheumatoid Arthritis

(2010) S. R. Pickens et al.   JOURNAL OF IMMUNOLOGY

Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice

(2010) A. Kudva et al.   JOURNAL OF IMMUNOLOGY

Th17 cells, Jobʼs syndrome and HIV: opportunities for bacterial and fungal infections

(2010) Joshua D Milner et al.   Current Opinion in HIV and AIDS

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Critical Role of IL-17RA in Immunopathology of Influenza Infection

(2009) C. R. Crowe et al.   JOURNAL OF IMMUNOLOGY

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Interferon and cytokine responses to SARS-coronavirus infection

(2008) Volker Thiel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women

(2008) M Sumarac-Dumanovic et al.   INTERNATIONAL JOURNAL OF OBESITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE