SIRT1–NOX4 signaling axis regulates cancer cachexia

Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy

(2019) Angara Zambrano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The physiopathologic role of oxidative stress in skeletal muscle

(2018) Bianca Maria Scicchitano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia

(2018) Johanna Ábrigo et al.   Oxidative Medicine and Cellular Longevity

Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice

(2018) Tomoyasu Kadoguchi et al.   Frontiers in Physiology

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Dual Effects of Resveratrol on Cell Death and Proliferation of Colon Cancer Cells

(2017) Álvaro San Hipólito-Luengo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

(2017) Weijin Zhang et al.   Oxidative Medicine and Cellular Longevity

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

(2017) Huai-Qiang Ju et al.   Nature Communications

Establishment and characterization of a novel murine model of pancreatic cancer cachexia

(2017) Katherine A. Michaelis et al.   Journal of Cachexia Sarcopenia and Muscle

The sirt1/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells

(2016) Yulong Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

The physiological roles of Sirt1 in skeletal muscle

(2016) Patricia S. Pardo et al.   Aging-US

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

(2015) Adam P. Sharples et al.   AGING CELL

Resveratrol in the treatment of pancreatic cancer

(2015) Qinhong Xu et al.   Annals of the New York Academy of Sciences

Sirtuins and the Metabolic Hurdles in Cancer

(2015) Natalie J. German et al.   CURRENT BIOLOGY

SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo

(2015) Chern Ein Oon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro

(2015) J.W. Wu et al.   GENETICS AND MOLECULAR RESEARCH

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

(2015) Surendra K. Shukla et al.   Oncotarget

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

(2015) Fiorella Ghisays et al.   Cell Reports

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients

(2015) Liane M. McGlynn et al.   PLoS One

Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force

(2014) M. Aapro et al.   ANNALS OF ONCOLOGY

Targeting FoxO1 with AS1842856 Suppresses Adipogenesis

(2014) Peng Zou et al.   CELL CYCLE

Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins

(2014) WENPENG DONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resveratrol plays dual roles in pancreatic cancer cells

(2014) Lei Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons

(2013) Adam J. Case et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide dismutase mimic, MnTE-2-PyP5+ ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum

(2013) John O. Archambeau et al.   Redox Biology

Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells

(2012) Clintoria R. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

(2012) N. V. Chaika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells

(2012) Reas S. Khan et al.   Frontiers in Cellular Neuroscience

Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting

(2012) John J McCarthy et al.   Skeletal Muscle

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo

(2011) Scott Shadfar et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Oxidative stress and muscle homeostasis

(2010) Antonio Musarò et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

SirT1 in muscle physiology and disease: lessons from mouse models

(2010) M. Vinciguerra et al.   Disease Models & Mechanisms

Skeletal Muscle NADPH Oxidase Is Increased and Triggers Stretch-Induced Damage in the mdx Mouse

(2010) Nicholas P. Whitehead et al.   PLoS One

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic cancerrelated cachexia: influence on metabolism and correlation to weight loss and pulmonary function

(2009) Jeannine Bachmann et al.   BMC CANCER

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Sirt1 increases skeletal muscle precursor cell proliferation

(2008) Christopher R. Rathbone et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium

(2008) S. Varma Penumathsa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer

(2008) Jeannine Bachmann et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY