Resveratrol in the treatment of pancreatic cancer

Pancreatic cancer stem cells: New insight into a stubborn disease

(2015) Han-xiang Zhan et al.   CANCER LETTERS

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

(2015) V. Adorno-Cruz et al.   CANCER RESEARCH

Resveratrol Attenuates Intermittent Hypoxia-Induced Macrophage Migration to Visceral White Adipose Tissue and Insulin Resistance in Male Mice

(2015) Alba Carreras et al.   ENDOCRINOLOGY

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells

(2015) Shuhei Suzuki et al.   Oncotarget

Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism

(2014) Pei-Wen Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hyperglycemia Regulates TXNIP/TRX/ROS Axis via p38 MAPK and ERK Pathways in Pancreatic Cancer

(2014) Wei Li et al.   CURRENT CANCER DRUG TARGETS

Cancer stem cells - important players in tumor therapy resistance

(2014) Selcuk Colak et al.   FEBS Journal

Resveratrol plays dual roles in pancreatic cancer cells

(2014) Lei Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hyperglycemia, a Neglected Factor during Cancer Progression

(2014) Wanxing Duan et al.   Biomed Research International

Hyperglycemia as a Risk Factor for Cancer Progression

(2014) Tae Young Ryu et al.   Diabetes & Metabolism Journal

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo

(2013) Jiefang Guo et al.   CANCER LETTERS

Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression

(2013) P. Liu et al.   Clinical & Translational Oncology

Resveratrol Inhibits the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells Via Suppression of the PI-3K/Akt/NF-κB Pathway

(2013) Wei Li et al.   CURRENT MEDICINAL CHEMISTRY

Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?

(2013) Adriana Borriello et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

(2013) Yao-An Shen et al.   Evidence-based Complementary and Alternative Medicine

Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells

(2013) Philipp Saiko et al.   INVESTIGATIONAL NEW DRUGS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

3,5,4′-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition

(2013) Jie-Heng Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin

(2012) Il-Rae Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma

(2012) Rakesh Popat et al.   BRITISH JOURNAL OF HAEMATOLOGY

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

(2012) Biagio Arcidiacono et al.   Experimental Diabetes Research

Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain

(2012) Dipti V Tillu et al.   Molecular Pain

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

(2012) Antje Bruckbauer et al.   Nutrition & Metabolism

Resveratrol Inhibits Proliferation and Induces Apoptosis through the Hedgehog Signaling Pathway in Pancreatic Cancer Cell

(2012) Wenhui Mo et al.   PANCREATOLOGY

Current Knowledge on Pancreatic Cancer

(2012) Juan Iovanna et al.   Frontiers in Oncology

Resveratrol and cellular mechanisms of cancer prevention

(2011) Yogeshwer Shukla et al.   Annals of the New York Academy of Sciences

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

(2011) P. Palsamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol inhibits the epidermal growth factor-induced epithelial mesenchymal transition in MCF-7 cells

(2011) Daniele Vergara et al.   CANCER LETTERS

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics

(2011) L. M. Howells et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Effect of food on the pharmacokinetic profile of trans-resveratrol

(2011) M. Vaz-da-Silva et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis

(2011) Yi-Ping Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer

(2011) Uzma Shamim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75

(2011) Diane M. Harris et al.   Metabolomics

Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy

(2011) Dhanya Nambiar et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition

(2011) Sharmila Shankar et al.   PLoS One

Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors

(2011) Sanjit K. Roy et al.   PLoS One

Diabetes and risk of pancreatic cancer: a pooled analysis of three large case–control studies

(2010) Donghui Li et al.   CANCER CAUSES & CONTROL

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

(2010) H.-H. S. Chow et al.   Cancer Prevention Research

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Insulin resistance and cancer: Epidemiological evidence

(2010) Shoichiro Tsugane et al.   CANCER SCIENCE

Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects

(2010) Charles la Porte et al.   CLINICAL PHARMACOKINETICS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells

(2008) Astrid Bernhaus et al.   CANCER LETTERS

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

(2008) Astrid Bernhaus et al.   INVESTIGATIONAL NEW DRUGS

Resveratrol inhibits heregulin-β1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells☆

(2007) F TANG et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The insulin-suppressive effect of resveratrol — An in vitro and in vivo phenomenon

(2007) Tomasz Szkudelski   LIFE SCIENCES