Dioscin elicits anti‐tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer

Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2

(2018) Honglin Li et al.   BMC CANCER

Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression

(2018) Yao-Chen Wang et al.   International Journal of Biological Sciences

Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections

(2018) Xufeng Tao et al.   PHARMACOLOGICAL RESEARCH

Involvement of JNK signaling in IL4-induced M2 macrophage polarization

(2017) Jin Hao et al.   EXPERIMENTAL CELL RESEARCH

Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization

(2017) Yu Kou et al.   INTERNATIONAL JOURNAL OF CANCER

The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation

(2017) Toyohisa Iriki et al.   LUNG CANCER

Targeting tumor associated macrophages: The new challenge for nanomedicine

(2017) Fernando Torres Andón et al.   SEMINARS IN IMMUNOLOGY

Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β

(2017) Xufeng Tao et al.   Cell Death & Disease

Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model

(2017) Chanju Lee et al.   Oncotarget

Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression

(2017) Meiyu Peng et al.   Oncotarget

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

(2017) Xiang Zheng et al.   Oncotarget

E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer

(2017) Min Xu et al.   Frontiers in Pharmacology

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam ( Dioscorea villosa ) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

(2016) Pranapda Aumsuwan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inflammation-induced up-regulation of hepcidin and down-regulation of ferroportin transcription are dependent on macrophage polarization

(2016) Rafiou Agoro et al.   BLOOD CELLS MOLECULES AND DISEASES

Potent effects of dioscin against gastric cancer in vitro and in vivo

(2016) Xinwei Zhao et al.   PHYTOMEDICINE

Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

(2016) Guangxian Zhang et al.   PHYTOMEDICINE

Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1

(2016) Changyuan Wang et al.   Scientific Reports

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor microenvironment: Sanctuary of the devil

(2015) Lanlan Hui et al.   CANCER LETTERS

Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion

(2015) Xiaolong Yan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nanomedicine and cancer immunotherapy – targeting immunosuppressive cells

(2015) Fernando Torres Andón et al.   JOURNAL OF DRUG TARGETING

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

(2015) Jun Zhang et al.   Oncotarget

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression

(2015) Ang Yuan et al.   Scientific Reports

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Macrophage polarization

(2014) Jan Van den Bossche et al.   CURRENT OPINION IN LIPIDOLOGY

Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages

(2014) Lidia Jiménez-Garcia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway

(2013) Yongli Wei et al.   FOOD AND CHEMICAL TOXICOLOGY

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dioscin Restores the Activity of the Anticancer Agent Adriamycin in Multidrug-Resistant Human Leukemia K562/Adriamycin Cells by Down-Regulating MDR1 via a Mechanism Involving NF-κB Signaling Inhibition

(2013) Lijuan Wang et al.   JOURNAL OF NATURAL PRODUCTS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells

(2011) Bu Tong Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin upregulation

(2011) Hernan Roca et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time

(2010) Junliang Ma et al.   BMC CANCER

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics

(2010) Rita A Mukhtar et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY