Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition

(2015) Xufeng Tao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells

(2015) Li Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells

(2014) Stefania Meschini et al.   Autophagy

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway

(2014) Ting Chen et al.   CANCER BIOLOGY & THERAPY

ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer

(2014) Mary M. Heckler et al.   FEBS Journal

Sweat but no gain: Inhibiting proliferation of multidrug resistant cancer cells with “ersatzdroges”

(2014) Yoonseok Kam et al.   INTERNATIONAL JOURNAL OF CANCER

Combination of Apolipoprotein A1-Modi Liposome–Doxorubicin with Autophagy Inhibitors Overcame Drug Resistance In Vitro

(2014) Baolong Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Nanomaterial-Induced Autophagy: A New Reversal MDR Tool in Cancer Therapy?

(2014) Elisa Panzarini et al.   MOLECULAR PHARMACEUTICS

Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways

(2014) Qingyi Tong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo

(2014) Lijuan Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dioscin Attenuates Hepatic Ischemia-Reperfusion Injury in Rats Through Inhibition of Oxidative-Nitrative Stress, Inflammation and Apoptosis

(2014) Xufeng Tao et al.   TRANSPLANTATION

Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines

(2013) Ming-Ju Hsieh et al.   ARCHIVES OF TOXICOLOGY

Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades

(2013) Xinhua Qu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Breast cancer subtypes: response to radiotherapy and potential radiosensitisation

(2013) F E Langlands et al.   BRITISH JOURNAL OF RADIOLOGY

Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin

(2013) Xiaokui Huo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dioscin Restores the Activity of the Anticancer Agent Adriamycin in Multidrug-Resistant Human Leukemia K562/Adriamycin Cells by Down-Regulating MDR1 via a Mechanism Involving NF-κB Signaling Inhibition

(2013) Lijuan Wang et al.   JOURNAL OF NATURAL PRODUCTS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-κB in R-HepG2 Cell Line

(2012) Jianguo Sun et al.   PLoS One

Autophagy and Transporter-Based Multi-Drug Resistance

(2012) Priyank Kumar et al.   Cells

Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2011) F. Cardoso et al.   ANNALS OF ONCOLOGY

Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells

(2011) Bu Tong Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oroxylin a reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway

(2011) Hui-Ying Yang et al.   MOLECULAR CARCINOGENESIS

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

(2010) Y.-j. Mi et al.   CANCER RESEARCH

A green and efficient protocol for industrial-scale preparation of dioscin from Dioscorea nipponica Makino by two-step macroporous resin column chromatography

(2010) Lianhong Yin et al.   CHEMICAL ENGINEERING JOURNAL

Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-κB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells

(2010) Tran Thi Hien et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Application of Proteomic and Bioinformatic Techniques for Studying the Hepatoprotective Effect of Dioscin against CCl4-induced Liver Damage in Mice

(2010) Binan Lu et al.   PLANTA MEDICA

Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer

(2008) Helen M. Coley   CANCER TREATMENT REVIEWS

PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines

(2008) Mariana G. García et al.   LEUKEMIA RESEARCH

Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway

(2007) Byeong Hyeok Choi et al.   CANCER LETTERS