Upregulation of Alzheimer’s Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury

(2019) Wei Wang et al.   EBioMedicine

A Curcumin Analog Reduces Levels of the Alzheimer’s Disease-Associated Amyloid-β Protein by Modulating AβPP Processing and Autophagy

(2019) Yu Wan et al.   JOURNAL OF ALZHEIMERS DISEASE

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

(2018) WonHee Kim et al.   Molecular Neurodegeneration

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome

(2018) Can Zhang et al.   PLoS One

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis

(2018) Can Zhang et al.   Scientific Reports

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

(2018) Tina Heiland et al.   GLIA

Pharmacological and Toxicological Properties of the Potent Oral γ -Secretase Modulator BPN-15606

(2017) Steven L. Wagner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

(2017) Katarzyna Marta Zoltowska et al.   Molecular Neurodegeneration

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

(2017) Frank Raven et al.   EBioMedicine

Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density

(2017) Can Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

(2017) Myles R. Minter et al.   Scientific Reports

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2016) G. D. Manocha et al.   JOURNAL OF NEUROSCIENCE

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes

(2016) Mei-Chen Liao et al.   JOURNAL OF NEUROSCIENCE

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments

(2015) Haizhi Wang et al.   BIOCHEMISTRY

Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages

(2015) L. Devi et al.   NEUROSCIENCE

Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques

(2015) Elena Galea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of  -Amyloid by Cells Other Than Excitatory Neurons

(2014) K. Veeraraghavalu et al.   JOURNAL OF NEUROSCIENCE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Detrimental Effect of Genetic Inhibition of B-Site App-Cleaving Enzyme 1 on Functional Outcome after Controlled Cortical Impact in Young Adult Mice

(2011) Rebekah C. Mannix et al.   JOURNAL OF NEUROTRAUMA

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

(2011) Kengo Uemura et al.   Molecular Neurodegeneration

Loss of Function ofATXN1Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

(2009) David J Loane et al.   NATURE MEDICINE

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE