Article
Environmental Sciences
Xiangrui Wang, Wen-Xiong Wang
Summary: This study demonstrated that Cu2O microparticles were rapidly dissolved to copper ions inside cells, followed by lysosome-mediated exocytosis. Smaller microparticles had a lower uptake rate but dissolved more quickly, leading to faster exocytosis activation. The rapid release of copper ions resulted in immediate toxic effects, mainly through necrosis, while glutathione buffering ability alleviated copper toxicity. The turnover of intracellular copper was much faster at sublethal exposure levels, but the labile copper(I) concentration only increased by a maximum of 2 times. Tolerance to copper-based nanoparticles depended on their ability to discharge released copper ions.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Nancy Wiebelhaus, Jacqueline M. Zaengle-Barone, Kevin K. Hwang, Katherine J. Franz, Michael C. Fitzgerald
Summary: This study utilized protein folding stability and expression level analysis to investigate the effects of copper and two ionophores on E. coli, revealing copper-driven stability changes in proteins related to metabolism, translation, and cell redox homeostasis. The results highlight the unique information that protein stability measurements can offer in understanding metal-dependent processes in drug mode of action studies.
ACS CHEMICAL BIOLOGY
(2021)
Review
Multidisciplinary Sciences
Qingdian Mu, Liyun Chen, Xiaotong Gao, Shuying Shen, Wenjing Sheng, Junxia Min, Fudi Wang
Summary: The article reviews the role of iron in regulating biological processes, immune system development and maintenance, as well as the importance of iron in regulating the inflammatory response and infectious disease processes, the competition between host and pathogen for iron, and the therapeutic implications of targeting iron-related processes for protection against pathogen infection, inflammation control, and improving the efficacy of immunotherapy.
Article
Chemistry, Multidisciplinary
Gulshan R. Walke, Shelly Meron, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Summary: The ATSM-Cu(II) complex shows promising potential as a PET agent for hypoxia imaging in detecting tumors. The study reveals its toxicity to breast cancer cells and higher levels of Cu(I) content in those cells under hypoxic conditions, indicating a higher redox potential in cancer cells compared to normal cells.
Review
Metallurgy & Metallurgical Engineering
Yang -gang Wang, Hao-yang LI, Xiao-yan Yuan, Yan-bin Jiang, Zi-an Xiao, Zhou LI
Summary: This review discusses the relationship between copper, human, and bacteria, focusing on copper antibacterial activity and mechanisms. The results show that copper's antibacterial activity is influenced by various factors and different manufacturing methods are discussed. These findings are important for understanding the role of copper in human immune defense.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2022)
Review
Pharmacology & Pharmacy
Raziye Mohammapdour, Hamidreza Ghandehari
Summary: Research has elucidated the cellular and molecular mechanisms of interaction between inorganic nanoparticles and the immune system, with a specific focus on the immune response to the degradation products. The importance of designing new methods and instruments for assessing the safety of inorganic nanoparticles was emphasized.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
David J. Pinato, Thomas U. Marron, Pallavi Shruti Mishra-Kalyani, Yutao Gong, Guo Wei, David Szafron, Elad Sharon, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Abdul R. Naqash, Thoetchai Peeraphatdit, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Chieh J. Lee, Pei-Chang Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia Abugabal, Tiziana Pressiani, Nicola Personeni, Antonio D'Alessio, Ahmed O. Kaseb, Yi-Hsiang Huang, Celina Ang, Julie Schneider, Anjana Pillai, Lorenza Rimassa, Kirsten B. Goldberg, Richard Pazdur, Marc Theoret, Steven Lemery, Lola Fashoyin-Aje, Alessio Cortellini, Lorraine Pelosof
Summary: The development of treatment-related adverse events (trAE) correlates favorably with clinical outcomes in patients with hepatocellular carcinoma (HCC) receiving immune checkpoint inhibitors (ICI) in international clinical trials, indicating potential predictive value for treatment response.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Jingyi Hou, Ruiyang Xie, Zhuo Zhang, Qianxin Liu, Qian Xiang, Yimin Cui
Summary: The risk of treatment-related hematologic toxicity in patients with advanced and metastatic gastrointestinal cancers treated with immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy is unclear. This study found that using ICIs alone had a low incidence of causing hematologic mortality and adverse events, while combining ICIs with chemotherapy might magnify the side effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Joan B. Mannick, Grace Teo, Patti Bernardo, Dean Quinn, Kerry Russell, Lloyd Klickstein, William Marshall, Sarb Shergill
Summary: The study found that low doses of the mTOR inhibitor RTB101 are well tolerated and can upregulate IFN-induced antiviral responses in older adults. Further refinement of clinical trial endpoints and patient populations may be needed to determine whether upregulation of IFN responses by mTOR inhibitors consistently decreases the incidence or severity of viral infections in older adults.
LANCET HEALTHY LONGEVITY
(2021)
Article
Hematology
Christian Messerli, Gertrud Wiedemann, Naomi Porret, Michael Nagler, Katja Seipel, Barbara Jeker, Urban Novak, Sacha Zeerleder, Ulrike Bacher, Thomas Pabst
Summary: Cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are significant complications in CAR-T cell therapy for patients with diffuse large B-cell lymphoma, and higher CAR-T cell peak expression may be associated with increased risk of ICANS.
TURKISH JOURNAL OF HEMATOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Nikolai F. Romashev, Pavel A. Abramov, Ivan Bakaev, Iakov S. Fomenko, Denis G. Samsonenko, Alexander S. Novikov, Kelvin K. H. Tong, Dohyun Ahn, Pavel Dorovatovskii, Yan Zubavichus, Aleksey A. Ryadun, Olga A. Patutina, Maxim N. Sokolov, Maria Babak, Artem L. Gushchin
Summary: A series of Pt and Pd complexes with dpp-Bian and different ligands were synthesized and characterized. The Pt(dpp-Bian) complexes showed high anticancer activity at low concentrations and exhibited selectivity towards cancer cells. These complexes induced the generation of reactive oxygen species in cancer cells and were able to intercalate into DNA.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Anastasiia S. Sivchenko, Felix Bacher, Kelvin K. H. Tong, Navjot Guru, Thomas Wilson, Junior Gonzales, Hartmut Rauch, Susanne Kossatz, Thomas Reiner, Maria Babak, Vladimir B. Arion
Summary: In this study, a series of novel indololatonduine derivatives and their Ru-II and Os-II complexes were synthesized, and their microtubule-targeting properties were compared with paclitaxel and colchicine. The novel indololatonduines showed anticancer activity, while coordination to metal centers resulted in a decrease of cytotoxicity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Irina Kuznetcova, Felix Bacher, Samah Mutasim Alfadul, Max Jing Rui Tham, Wee Han Ang, Maria V. Babak, Peter Rapta, Vladimir B. Arion
Summary: A small library of novel indolo[3,2-d][2]benzazepine-derived ligands and their copper complexes was prepared, and their antiproliferative activity in vitro was tested. The compounds showed high anticancer activity in breast cancer and hepatocellular carcinoma cell lines, with important structure-activity relationships observed.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yulia M. Ohorodnik, Alexander A. Sikalov, Dmytro M. Khomenko, Roman O. Doroshchuk, Ilona Raspertova, Sergiu Shova, Maria Babak, Rostyslav D. Lampeka
Summary: The structures of new p-cymene Ru(II) complexes with 2-(1-methyl-1H-1,2,4-triazol-3-yl)pyridine and 2-(1-methyl-1H-1,2,4-triazol-5-yl)pyridine were determined and their anticancer activity against human ovarian cancer cells was reported.
TRANSITION METAL CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Meng Rui Chang, Daniil A. Rusanov, Jemma Arakelyan, Mana Alshehri, Aleksandra Asaturova, Galina S. Kireeva, Maria Babak, Wee Han Ang
Summary: In the last decade, our understanding of cancer development and progression has expanded, with the recognition of specific hallmarks of cancer. These hallmarks have been widely accepted as an organizing principle to comprehend cancer and develop new therapies. Recent research has revealed new hallmarks related to the interaction between cancer cells and their tumor microenvironment. This review summarizes therapeutic strategies targeting phenotypic plasticity and the cancer microbiome, and explores the potential advantages of transition metal complexes as compared to current treatment options.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Jemma Arakelyan, Daniil A. Rusanov, Meng Rui Chang, Aleksandra V. Asaturova, Galina S. Kireeva, Mana Alshehri, Wee Han Ang, Maria V. Babak
Summary: In the past decade, our understanding of the complex factors and processes that drive cancer development and progression has expanded. Cancer can now be characterized by specific hallmarks that normal cells need to acquire to become malignant. New hallmarks have emerged from studying the interaction between cancer cells and their tumor microenvironment. This review focuses on the use of transition metals as therapeutic drugs for cancers caused by epigenetic dysregulation and compares their effectiveness to existing drugs.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Daniil A. Rusanov, Samah Mutasim Alfadul, Ekaterina Yu. Portnyagina, Eugenia A. Silyanova, Nikita A. Kuznetsov, Kirill E. Podpovetny, Alexander V. Samet, Victor V. Semenov, Maria V. Babak
Summary: Researchers discovered the anticancer properties of Lamellarin D, a naturally occurring hexacyclic marine alkaloid, and attempted to prepare synthetic analogues to understand the effects of each structural component on their activity. This study developed a simple and straightforward method to synthesize E-ring-free lamellarin analogues. These analogues were found to be non-toxic to cancer cells due to their poor solubility in cellular environment.
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Pavel A. A. Egorov, Dmitry A. A. Grishanov, Alexander G. G. Medvedev, Andrei V. V. Churakov, Alexey A. A. Mikhaylov, Roman V. V. Ottenbacher, Konstantin P. P. Bryliakov, Maria V. V. Babak, Ovadia Lev, Petr V. V. Prikhodchenko
Summary: This study successfully synthesized and characterized six triaryl and trialkylantimony dihydroperoxides. The crystal structures of these compounds revealed hydrogen-bonded networks formed by hydroperoxo ligands, including infinite hydroperoxo chains. The potential of triphenylantimony dihydroperoxide as a two-electron oxidant in an enantioselective epoxidation reaction was investigated, comparing it with other oxidants.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Olga Zharkova, Maryam F. Salamah, Maria V. Babak, Elanchezhian Rajan, Lina H. K. Lim, Frans Andrade, Cristiane D. Gil, Sonia M. Oliani, Leonardo A. Moraes, Sakthivel Vaiyapuri
Summary: This study reveals that ANXA1 modulates platelet function through its receptor Fpr2/3. ANXA1(Ac2-26) activates platelets, leading to increased fibrinogen binding and P-selectin exposure. It also enhances platelet-leukocyte aggregates. These findings suggest that ANXA1 plays a role in thrombosis, haemostasis, and platelet-mediated inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Samah Mutasim Alfadul, Egor M. Matnurov, Alexander E. Varakutin, Maria V. Babak
Summary: Metal complexes are potential alternatives to small organic molecules for cancer treatment. The structure of metal complexes can be easily modified due to the variety of metal oxidation states and geometries. This article aims to discuss their potential as p53-targeting drugs.
Article
Chemistry, Inorganic & Nuclear
Veronika I. Komlyagina, Nikolai F. Romashev, Victoria K. Besprozvannykh, Jemma Arakelyan, Chengnan Wu, Alexey S. Chubarov, Ivan V. Bakaev, Yee Kiat Soh, Pavel A. Abramov, Kin Leung Cheung, Nikolai B. Kompan'kov, Aleksey A. Ryadun, Maria V. Babak, Artem L. Gushchin
Summary: A series of heteroleptic bipyridine Pd(II) complexes with redox-active and DNA-binding bis(arylimino)acenaphthene-derived ligands were synthesized and fully characterized. These complexes showed anticancer activity in a low micromolar concentration range and exhibited selectivity towards cancer cells. The mechanism of action was linked to mitochondrial reactive oxygen species induction and DNA degradation.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yulia M. Ohorodnik, Dmytro M. Khomenko, Roman O. Doroshchuk, Ilona Raspertova, Sergiu Shova, Maria Babak, Miljan N. M. Milunovic, Rostyslav D. Lampeka
Summary: This study describes the synthesis, investigation, and in vitro cytotoxicity of Pt(II) complexes with 3-(2-pyridyl)-N1-methyl-1,2,4-triazole (L1) and 3-(2-pyridyl)-N2-methyl-1,2,4-triazole (L2). X-ray analysis confirmed the square-planar PtN2Cl2 coordination geometry for PtL1Cl2 and PtL2Cl2. HRMS and NMR spectroscopy showed the stability of the complexes in DMF solution. The cytotoxicity of the complexes was evaluated against cisplatin-sensitive and cisplatin-resistant human ovarian adenocarcinoma cells.
INORGANICA CHIMICA ACTA
(2023)
Letter
Medicine, General & Internal
Robert Peter Gale, Armen Muradyan, Samvel Danelyan, Narek Manukyan, Maria Babak, Stella Arakelyan, Gevorg Tamamyan, Jemma Arakelyan
Article
Chemistry, Multidisciplinary
Elena E. Bardina, Nikita Y. Shmelev, Yana N. Albrekht, Winnie Ka Yiu Koon, Pavel A. Abramov, Irina V. Mirzaeva, Dmitriy G. Sheven', Evgeniya V. Makotchenko, Iakov S. Fomenko, Anton N. Lukoyanov, Maxim N. Sokolov, Maria V. Babak, Artem L. Gushchin
Summary: The synthesis, characterization and properties of a series of cationic Au(i)-BIAN/MIAN complexes were studied in this work. The complexes exhibited unique coordination modes and reduction processes, and preliminary bioactivity tests were also conducted.
NEW JOURNAL OF CHEMISTRY
(2023)