Berberine: A novel therapeutic strategy for cancer

New Development of Novel Berberine Derivatives against Bacteria

(2020) Faisal Jamshaid et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer

(2020) Ye Wang et al.   OncoTargets and Therapy

Recent Advances in Berberine Inspired Anticancer Approaches: From Drug Combination to Novel Formulation Technology and Derivatization

(2020) Solomon Habtemariam   MOLECULES

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

(2020) Heng Li et al.   Cell Death & Disease

Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling

(2020) Jian Liu et al.   Drug Design Development and Therapy

Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways

(2020) Qiang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Berberine as a potential autophagy modulator

(2019) Reza Mohammadinejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Natural products: An upcoming therapeutic approach to cancer

(2019) Sayanta Dutta et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

(2019) Mingjiang Yao et al.   BMC Complementary and Alternative Medicine

An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology

(2019) Pengfei Guo et al.   Frontiers in Pharmacology

MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells

(2019) Jian Liu et al.   LIFE SCIENCES

Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

(2019) Yunxin Liu et al.   BIOCHEMICAL PHARMACOLOGY

Application of Traditional Chinese Medicines as Personalized Therapy in Human Cancers

(2018) Sumei Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Nano strategies for berberine delivery, a natural alkaloid of Berberis

(2018) Elaheh Mirhadi et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1

(2018) Yan–Xiang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cell-specific pattern of berberine pleiotropic effects on different human cell lines

(2018) Alessandro Agnarelli et al.   Scientific Reports

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats

(2018) Laila Ahmed Eissa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro

(2018) Jia-Fang Liu et al.   MOLECULES

Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells

(2018) Sindy Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma

(2018) Bingling Dai et al.   PHYTOTHERAPY RESEARCH

Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma

(2018) Qian Hu et al.   Frontiers in Pharmacology

Inhibition of autophagy by berberine enhances the survival of H9C2 myocytes following hypoxia

(2017) Zhuyin Jia et al.   Molecular Medicine Reports

Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells

(2017) Xiaoqin La et al.   Oncotarget

Berberine improves the intestinal antioxidant status of laboratory mice, Mus musculus

(2017) Mohamed A. Dkhil et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Berberine-induced changes in protein expression and antioxidant enzymes in melanoma cells

(2016) Ji-Hae Kim et al.   Molecular & Cellular Toxicology

Berberine and inflammatory bowel disease: A concise review

(2016) Solomon Habtemariam   PHARMACOLOGICAL RESEARCH

Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells

(2016) Yujie Zhao et al.   Oncotarget

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

(2016) Qun Chu et al.   Oncotarget

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

(2016) Kai Wang et al.   Scientific Reports

Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

(2015) Yan Zhou et al.   APOPTOSIS

Discovery and resupply of pharmacologically active plant-derived natural products: A review

(2015) Atanas G. Atanasov et al.   BIOTECHNOLOGY ADVANCES

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance

(2015) Chia-Hung Liu et al.   International Journal of Medical Sciences

Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses

(2015) Masaaki Kawano et al.   JOURNAL OF NEUROIMMUNOLOGY

Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells

(2015) JAE-SUNG KIM et al.   ONCOLOGY REPORTS

Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway

(2015) Xuan Liu et al.   PLoS One

Berberine and Its Metabolites: Relationship between Physicochemical Properties and Plasma Levels after Administration to Human Subjects

(2014) Silvia Spinozzi et al.   JOURNAL OF NATURAL PRODUCTS

Berberine, an Epiphany Against Cancer

(2014) Luis Guamán Ortiz et al.   MOLECULES

Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

(2014) Chandraiah Godugu et al.   PLoS One

Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes

(2013) Xu Ma et al.   BIOMATERIALS

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

(2013) Abeer E Abd El-Wahab et al.   BMC Complementary and Alternative Medicine

Berberine Reduces the Metastasis of Chondrosarcoma by Modulating theαvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways

(2013) Chi-Ming Wu et al.   Evidence-based Complementary and Alternative Medicine

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

(2013) Robert Domitrović et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo

(2013) Yuchen Cai et al.   Journal of Natural Medicines

Role of plants in anticancer drug discovery

(2013) Jabeena Khazir et al.   Phytochemistry Letters

Berberine Ameliorates Experimental Autoimmune Neuritis by Suppressing both Cellular and Humoral Immunity

(2013) H. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Set9, NF-κB and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

(2012) Hai-yan Hu et al.   ACTA PHARMACOLOGICA SINICA

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Berberine and its derivatives: a patent review (2009 – 2012)

(2012) Inder Pal Singh et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression

(2011) Hak-Su Kim et al.   BIOCHEMICAL PHARMACOLOGY

Apoptosis: why and how does it occur in biology?

(2011) Engin Ulukaya et al.   CELL BIOCHEMISTRY AND FUNCTION

Berberine Inhibits Pulmonary Metastasis through Down-regulation of MMP in Metastatic B16F-10 Melanoma Cells

(2011) T. P. Hamsa et al.   PHYTOTHERAPY RESEARCH

Assessment of the Evolution of Cancer Treatment Therapies

(2011) Manuel Arruebo et al.   Cancers

Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery

(2010) Sunil Kumar Battu et al.   AAPS PHARMSCITECH

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

(2010) Y.-T. Liu et al.   DRUG METABOLISM AND DISPOSITION

Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism

(2010) Ning Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-κB pathway and subsequently downregulating expression of matrix metalloproteinases

(2010) Po-Len Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

(2009) Jun Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery

(2009) Emily Gullotti et al.   MOLECULAR PHARMACEUTICS

Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage

(2009) Zhaojian Liu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

(2008) Mohsen Imanshahidi et al.   PHYTOTHERAPY RESEARCH