Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 289, Issue -, Pages 43-55Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2015.10.001
Keywords
Berberine; Antagonist; Dopamine receptors; Innate immune response; Autoimmune disease; T helpers
Categories
Funding
- Tsumura Co.
- Japanese Society for the Promotion of Science [22790940, 26860112, 23591466, 15K15375]
- Ochiai memorial award
- Grants-in-Aid for Scientific Research [15K15375, 22790940, 26860112, 23591466] Funding Source: KAKEN
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Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors and ameliorates the development of experimentally induced colitis in mice. In lipopolysaccharide-stimulated immune cells, berberine treatment modified cytokine levels, consistent with the effects of the dopamine receptor specific antagonists SCH23390 and L750667. Our findings indicate that dopamine receptor antagonists suppress innate and adaptive immune responses, providing a foundation for their use in combatting inflammatory diseases. (C) 2015 Elsevier B.V. All rights reserved.
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