Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

Betulinic acid suppresses NGAL-induced epithelial-to-mesenchymal transition in melanoma

(2013) Dorina Gheorgheosu et al.   BIOLOGICAL CHEMISTRY

Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes

(2013) Xu Ma et al.   BIOMATERIALS

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

(2013) Abeer E Abd El-Wahab et al.   BMC Complementary and Alternative Medicine

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo

(2013) Xi Yang et al.   CANCER BIOLOGY & THERAPY

Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhalation delivery of Telmisartan enhances intratumoral distribution of nanoparticles in lung cancer models

(2013) Chandraiah Godugu et al.   JOURNAL OF CONTROLLED RELEASE

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

(2013) Chandraiah Godugu et al.   PLoS One

Permeability Enhancers Dramatically Increase Zanamivir Absolute Bioavailability in Rats: Implications for an Orally Bioavailable Influenza Treatment

(2013) Eric H. Holmes et al.   PLoS One

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth

(2013) Lingyi Fu et al.   PLoS One

Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats

(2012) Dongjiao Fan et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway

(2012) Yan-Fang Sun et al.   FOOD CHEMISTRY

Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation

(2012) Han-Peng Kuo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

(2012) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Lipid-lowering effect of berberine in human subjects and rats

(2012) Yueshan Hu et al.   PHYTOMEDICINE

Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

(2011) Franziska B. Mullauer et al.   ANTI-CANCER DRUGS

Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?

(2011) Catia V. Diogo et al.   CURRENT DRUG TARGETS

Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats

(2011) Wei Chen et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine

(2011) Ting Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-Angiogenic Effects of Betulinic Acid Administered in Nanoemulsion Formulation Using Chorioallantoic Membrane Assay

(2011) Cristina A. Dehelean et al.   Journal of Biomedical Nanotechnology

Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells

(2011) Jimin Shin et al.   PLoS One

Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions

(2011) Matthias Bache et al.   Radiation Oncology

Betulinic acid, a natural compound with potent anticancer effects

(2010) Franziska B. Mullauer et al.   ANTI-CANCER DRUGS

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

(2010) Zhe Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

(2010) Y.-T. Liu et al.   DRUG METABOLISM AND DISPOSITION

Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism

(2010) Zi Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Targeting mitochondrial apoptosis by betulinic acid in human cancers

(2009) Simone Fulda et al.   DRUG DISCOVERY TODAY

Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound

(2009) M. Willmann et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Validation of a liquid chromatography–tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum

(2009) Prem K. Gupta et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

(2009) Yitong Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

(2009) Hao Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model

(2009) Yung-Tsuan Ho et al.   PHYTOMEDICINE

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

(2008) Yifei Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL