The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases

Diets naturally rich in polyphenols and/or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals

(2020) Claudia Vetrani et al.   ACTA DIABETOLOGICA

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo

(2020) Paul Dent et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice

(2019) Lize Zhang et al.   Molecular Medicine Reports

The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

(2019) Garrison Dyck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge

(2019) Mohd Iqbal Bhat et al.   ANNALS OF MICROBIOLOGY

Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice

(2019) Jinghua Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Ashkan Afshin et al.   LANCET

An In Vitro Study of the Influence of Curcuma longa Extracts on the Microbiota Modulation Process, In Patients with Hypertension

(2019) Emanuel Vamanu et al.   Pharmaceutics

Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity

(2019) Jing Zhu et al.   Journal of Functional Foods

Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota

(2019) Gomes et al.   Nutrients

Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes

(2019) Kun Zuo et al.   mSystems

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure

(2018) Seungbum Kim et al.   CLINICAL SCIENCE

Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials

(2018) Federica Fogacci et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Obesity treatment by epigallocatechin-3-gallate–regulated bile acid signaling and its enriched Akkermansia muciniphila

(2018) Lili Sheng et al.   FASEB JOURNAL

Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases

(2018) Qian Yi Eng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Obesity-Associated Diseases Biomarkers Are Differently Modulated in Lean and Obese Individuals and Inversely Correlated to Plasma Polyphenolic Metabolites After 6 Weeks of Mango (Mangifera indica L.) Consumption

(2018) Chuo Fang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial

(2018) Kamesh Venkatakrishnan et al.   Food & Function

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

(2018) Wanda C. Reygaert   Biomed Research International

Phytochemicals in Cardiovascular and Respiratory Diseases: Evidence in Oxidative Stress and Inflammation

(2018) Raluca M. Pop et al.   Oxidative Medicine and Cellular Longevity

Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid

(2018) Samantha Yuille et al.   PLoS One

Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice

(2018) Lifei Liu et al.   PLoS One

Comparative analysis of fecal phenolic content between normal and obese rats after oral administration of tea polyphenols

(2018) Bo Chen et al.   Food & Function

Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure

(2018) Tomohiro Hayashi et al.   CIRCULATION JOURNAL

Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites

(2018) Shuwei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice

(2017) Susanne M. Henning et al.   EUROPEAN JOURNAL OF NUTRITION

Nutritional value, phytochemical composition, and biological activities of edible Curcuma species: A review

(2017) Sanatombi Rajkumari et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification

(2017) Bo Pan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sodium Butyrate Protects ­Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice

(2017) Ling Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans

(2017) Janet A. Novotny et al.   MOLECULAR NUTRITION & FOOD RESEARCH

EGCG Prevents High Fat Diet-Induced Changes in Gut Microbiota, Decreases of DNA Strand Breaks, and Changes in Expression and DNA Methylation ofDnmt1andMLH1in C57BL/6J Male Mice

(2017) Marlene Remely et al.   Oxidative Medicine and Cellular Longevity

Alterations in the gut microbiota can elicit hypertension in rats

(2017) Sareema Adnan et al.   PHYSIOLOGICAL GENOMICS

Inhibition of high glucose-induced inflammation and fibrosis by a novel curcumin derivative prevents renal and heart injury in diabetic mice

(2017) Hongjin Chen et al.   TOXICOLOGY LETTERS

Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model

(2017) Jun Hu et al.   Experimental and Therapeutic Medicine

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

(2017) Mario Lorenz et al.   Scientific Reports

Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse

(2017) C.A. Danilo et al.   Beneficial Microbes

Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications

(2017) Liang Shen et al.   Food & Nutrition Research

Alterations of the Gut Microbiome in Hypertension

(2017) Qiulong Yan et al.   Frontiers in Cellular and Infection Microbiology

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

(2016) Hamed Samavat et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Diastolic dysfunction and cardiac troponin I decrease in aging hearts

(2016) B. Pan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1

(2016) Jin Ma et al.   Chinese Journal of Integrative Medicine

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Gut Microbiome Associates With Lifetime Cardiovascular Disease Risk Profile Among Bogalusa Heart Study ParticipantsNovelty and Significance

(2016) Tanika N. Kelly et al.   CIRCULATION RESEARCH

EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells

(2016) Dandan Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

(2016) Rebecca Wasilewski et al.   MICROVASCULAR RESEARCH

Lingonberries reduce atherosclerosis in Apoe-/- mice in association with altered gut microbiota composition and improved lipid profile

(2016) Chrysoula Matziouridou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of Sirtuins in Regulating Pathophysiology of the Heart

(2016) Samik Bindu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

(2016) Ming-liang Chen et al.   mBio

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2016) Susanne H. Karbach et al.   Journal of the American Heart Association

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

(2016) Tatsuya Morimoto et al.   International Journal of Chronic Obstructive Pulmonary Disease

Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling

(2016) Sin Young Choi et al.   PLoS One

The role of curcumin as an inhibitor of oxidative stress caused by ischaemia re-perfusion injury in tetralogy of Fallot patients undergoing corrective surgery

(2015) Rubiana Sukardi et al.   CARDIOLOGY IN THE YOUNG

Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

(2015) Youfang Chen et al.   Cardiovascular Diabetology

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Determining the Long-term Effect of Antibiotic Administration on the Human Normal Intestinal Microbiota Using Culture and Pyrosequencing Methods

(2015) Mamun-Ur Rashid et al.   CLINICAL INFECTIOUS DISEASES

Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials

(2015) Yanxia Liu et al.   CLINICAL NUTRITION

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

(2015) Jenny Y Y Ooi et al.   Epigenetics

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

(2015) Dae-Bang Seo et al.   JOURNAL OF MEDICINAL FOOD

Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

(2015) Chunlai Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sirtuin function in aging heart and vessels

(2015) Chiara Cencioni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling

(2014) Kimberly M. Demos-Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate

(2014) Sabita N. Saldanha et al.   EXPERIMENTAL CELL RESEARCH

Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes

(2014) Sarah M. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

(2014) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Seasonal Variation in Human Gut Microbiome Composition

(2014) Emily R. Davenport et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

(2014) Yi Qiao et al.   Food & Function

Antifibrotic response of cardiac fibroblasts in hypertensive hearts through enhanced TIMP-1 expression by basic fibroblast growth factor

(2013) Toshio Kinoshita et al.   CARDIOVASCULAR PATHOLOGY

Mediterranean and DASH Diet Scores and Mortality in Women With Heart Failure

(2013) Emily B. Levitan et al.   Circulation-Heart Failure

Balance of Nitric Oxide and Reactive Oxygen Species in Myocardial Reperfusion Injury and Protection

(2013) Anna Folino et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial

(2013) Somlak Chuengsamarn et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells

(2013) Sascha Venturelli et al.   PLoS One

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy

(2013) B. S. Ferguson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting

(2012) Wanwarang Wongcharoen et al.   AMERICAN JOURNAL OF CARDIOLOGY

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

(2012) Evangelia G. Kranias et al.   CIRCULATION RESEARCH

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report

(2012) Arnt V. Kristen et al.   Clinical Research in Cardiology

Phytochemicals from Plants to Combat Cardiovascular Disease

(2012) H.R. Vasanthi et al.   CURRENT MEDICINAL CHEMISTRY

Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide

(2012) Zhihong Yuan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol induces nuclear factor-κB activity in human cardiac cells

(2012) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system

(2012) Darab Ghadimi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease

(2012) Stephanie E. Chiuve et al.   JOURNAL OF NUTRITION

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

(2012) Joao Tomé-Carneiro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults

(2011) Mitchell L. Jones et al.   BRITISH JOURNAL OF NUTRITION

Bile Acids Regulate Cardiovascular Function

(2011) Sandeep Khurana et al.   CTS-Clinical and Translational Science

Databases on Food Phytochemicals and Their Health-Promoting Effects

(2011) Augustin Scalbert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

(2009) M. Sulaiman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells

(2009) Liqing Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotective and Antiinflammatory Properties of a Novel Demethylated Curcuminoid

(2008) Savita Khanna et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway

(2008) Chun-Juan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats

(2008) Tatsuya Morimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY