A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity

Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis

(2020) Holger Müller-Redetzky et al.   ANESTHESIOLOGY

Outpatient Treatment with Lisocabtagene Maraleucel (liso-cel) in 3 Ongoing Clinical Studies in Relapsed/Refractory (R/R) Large B Cell Non-Hodgkin Lymphoma (NHL), Including Second-Line Transplant Noneligible (TNE) Patients: Transcend NHL 001, Outreach, and PILOT

(2020) Carlos R. Bachier et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Breakthrough Hemolysis in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Ravulizumab: Results of a 52-Week Extension from Two Phase 3 Studies

(2020) Anita Hill et al.   BLOOD

Complement blockade for TA-TMA: lessons learned from large pediatric cohort treated with eculizumab

(2020) Sonata Jodele et al.   BLOOD

Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib

(2020) Jim S. Qin et al.   JOURNAL OF IMMUNOTHERAPY

CAR T cells: continuation in a revolution of immunotherapy

(2020) Anurag K Singh et al.   LANCET ONCOLOGY

Pretransplant Genetic Susceptibility: Clinical Relevance in Transplant-Associated Thrombotic Microangiopathy

(2020) Eleni Gavriilaki et al.   THROMBOSIS AND HAEMOSTASIS

CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead

(2020) Qingyang Zhang et al.   Journal of Immunology Research

Severe COVID‐19 infection and thrombotic microangiopathy: success does not come easily

(2020) Eleni Gavriilaki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Complementopathies and precision medicine

(2020) Eleni Gavriilaki et al.   JOURNAL OF CLINICAL INVESTIGATION

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Thrombotic microangiopathy following pediatric autologous hematopoietic cell transplantation: a report of significant end organ dysfunction in eculizumab treated survivors

(2019) Dr. Michelle Schoettler   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CAR T-cell associated neurotoxicity: Mechanisms, clinicopathologic correlates, and future directions

(2019) Bradley D Hunter et al.   JNCI-Journal of the National Cancer Institute

Hypertension in hematologic malignancies and hematopoietic cell transplantation: An emerging issue with the introduction of novel treatments

(2019) Eleni Gavriilaki et al.   BLOOD REVIEWS

Neurological adverse events post allogeneic hematopoietic cell transplantation: major determinants of morbidity and mortality

(2019) Ioanna Sakellari et al.   JOURNAL OF NEUROLOGY

Endothelial microvesicles circulating in peripheral and coronary circulation are associated with central blood pressure in coronary artery disease

(2019) E Gkaliagkousi et al.   AMERICAN JOURNAL OF HYPERTENSION

Chimeric Antigen Receptor T Cell-Related Neurotoxicity: Mechanisms, Clinical Presentation, and Approach to Treatment

(2019) Jessica Rice et al.   Current Treatment Options in Neurology

Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy

(2019) Eleni Gavriilaki et al.   THROMBOSIS AND HAEMOSTASIS

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

(2019) Yong Gu Lee et al.   Nature Communications

Autologous Hematopoietic Cell Transplantation in Multiple Sclerosis: Changing Paradigms in the Era of Novel Agents

(2019) Maria Gavriilaki et al.   Stem Cells International

Management of cytokine release syndrome related to CAR-T cell therapy

(2019) Hongli Chen et al.   Frontiers of Medicine

Neurologic complications after allogeneic transplantation: a meta‐analysis

(2019) Maria Gavriilaki et al.   Annals of Clinical and Translational Neurology

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

(2019) Antonio M. Risitano et al.   BLOOD

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

(2019) Austin Kulasekararaj et al.   BLOOD

One-Year Efficacy and Safety from a Phase 3 Trial of Ravulizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Prior Eculizumab Treatment

(2019) Austin Kulasekararaj et al.   BLOOD

Characterizing C5 Inhibition with the SMART-Ig Anti-hC5 Antibody Crovalimab in PNH Patients Using Free Available Paratopes

(2019) Alexandre Sostelly et al.   BLOOD

Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T)

(2019) Raza M. Alvi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-term outcomes of total body irradiation plus cyclophosphamide versus busulfan plus cyclophosphamide as conditioning regimen for acute lymphoblastic leukemia: a comparative study

(2018) Ioanna Sakellari et al.   ANNALS OF HEMATOLOGY

Defibrotide for Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease Prophylaxis in High-Risk Adult Patients: A Single-Center Experience Study

(2018) Adrien Picod et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Complement-coagulation connections

(2018) Edward M. Conway   BLOOD COAGULATION & FIBRINOLYSIS

Efficacy and safety analysis by age cohort of inotuzumab ozogamicin in patients with relapsed or refractory acute lymphoblastic leukemia enrolled in INO-VATE

(2018) Elias J. Jabbour et al.   CANCER

Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration

(2018) M.J. Geerlings et al.   CLINICAL GENETICS

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors)

(2018) K.L. Winthrop et al.   CLINICAL MICROBIOLOGY AND INFECTION

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

(2018) Amy J. Osborne et al.   JOURNAL OF IMMUNOLOGY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria

(2018) Dimitrios C. Mastellos et al.   SEMINARS IN HEMATOLOGY

Clinical and Biologic Correlates of Neurotoxicity Associated with CAR T Cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia (B-ALL)

(2018) Bianca D. Santomasso et al.   Cancer Discovery

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Gemtuzumab ozogamicin for de novo acute myeloid leukemia: final efficacy and safety updates from the open-label, phase 3 ALFA-0701 trial

(2018) Juliette Lambert et al.   HAEMATOLOGICA

Updated safety and long term clinical outcomes in TRANSCEND NHL 001, pivotal trial of lisocabtagene maraleucel (JCAR017) in R/R aggressive NHL.

(2018) Jeremy S. Abramson et al.   JOURNAL OF CLINICAL ONCOLOGY

ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells

(2018) Daniel W Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor-experienced adult patients with PNH: the 302 study

(2018) Austin G. Kulasekararaj et al.   BLOOD

Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study

(2018) Jong Wook Lee et al.   BLOOD

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management

(2018) Jennifer N. Brudno et al.   BLOOD REVIEWS

Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: Prospective single-center study

(2018) Ioanna Sakellari et al.   JOURNAL OF CLINICAL APHERESIS

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

(2018) Frederick L Locke et al.   LANCET ONCOLOGY

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

(2017) Ran Zhang et al.   Oncotarget

Terminal Complement Blockade after Hematopoietic Stem Cell Transplantation Is Safe without Meningococcal Vaccination

(2016) Sonata Jodele et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Eculizumab therapy in adults with allogeneic hematopoietic cell transplant-associated thrombotic microangiopathy

(2016) S Vasu et al.   BONE MARROW TRANSPLANTATION

Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome

(2016) Arthur J. Vaught et al.   EXPERIMENTAL HEMATOLOGY

Modified Ham test for atypical hemolytic uremic syndrome

(2015) E. Gavriilaki et al.   BLOOD

The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy

(2015) S. Jodele et al.   BLOOD

Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

(2015) M Mohty et al.   BONE MARROW TRANSPLANTATION

Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells

(2015) B L Levine   CANCER GENE THERAPY

Clinical Significance of Endothelial Dysfunction in Essential Hypertension

(2015) Eugenia Gkaliagkousi et al.   CURRENT HYPERTENSION REPORTS

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy

(2015) Flore Sicre de Fontbrune et al.   TRANSPLANTATION

Late Cardiovascular Complications after Hematopoietic Cell Transplantation

(2014) Eric J. Chow et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults

(2014) S. Jodele et al.   BLOOD

GVHD-associated chronic kidney disease after allogeneic haematopoietic cell transplantation

(2013) I Sakellari et al.   BONE MARROW TRANSPLANTATION

Urinary Excretion of C5b-9 in Severe Preeclampsia

(2013) Richard M. Burwick et al.   HYPERTENSION

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

(2013) Marco L. Davila et al.   PLoS One

A systematic review of eculizumab for atypical haemolytic uraemic syndrome (aHUS)

(2013) John Rathbone et al.   BMJ Open

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

(2013) Claudio Cortes et al.   Frontiers in Immunology

Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial

(2012) Selim Corbacioglu et al.   LANCET

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dexamethasone inhibits ICAM-1 and MMP-9 expression and reduces brain edema in intracerebral hemorrhagic rats

(2011) Jen-Tsung Yang et al.   ACTA NEUROCHIRURGICA

The role of the endothelium in the short-term complications of hematopoietic SCT

(2011) E Carreras et al.   BONE MARROW TRANSPLANTATION

Interactions between coagulation and complement—their role in inflammation

(2011) Katerina Oikonomopoulou et al.   Seminars in Immunopathology

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

(2011) Jane E. Salmon et al.   PLOS MEDICINE

Is Complement Alternative Pathway Disregulation Involved in Veno-Occlusive Disease of the Liver?

(2010) Alessandro Bucalossi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Hematopoietic cell transplantation and emerging viral infections

(2010) D. Chatzidimitriou et al.   JOURNAL OF MEDICAL VIROLOGY

Comparison of thrombotic microangiopathy after allogeneic hematopoietic cell transplantation with high-dose or nonmyeloablative conditioning

(2009) E Willems et al.   BONE MARROW TRANSPLANTATION

Renal Thrombotic Microangiopathy after Hematopoietic Cell Transplant: Role of GVHD in Pathogenesis

(2009) S. Changsirikulchai et al.   Clinical Journal of the American Society of Nephrology

Evaluation of Angiopoietins and Cell-Derived Microparticles after Stem Cell Transplantation

(2008) Shosaku Nomura et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE