Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells

Adoptive Immunotherapy for Cancer or Viruses

(2014) Marcela V. Maus et al.   Annual Review of Immunology

Manufacturing of highly functional and specific T cells for adoptive immunotherapy against virus from granulocyte colony-stimulating factor–mobilized donors

(2014) Lorea Beloki et al.   CYTOTHERAPY

Universal Artificial Antigen Presenting Cells to Selectively Propagate T Cells Expressing Chimeric Antigen Receptor Independent of Specificity

(2014) David Rushworth et al.   JOURNAL OF IMMUNOTHERAPY

Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients

(2013) Anna Casati et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Chimeric Antigen Receptor Therapy for Chronic Lymphocytic Leukemia

(2013) Marco L. Davila et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia

(2013) David M. Barrett et al.   HUMAN GENE THERAPY

A new approach to gene therapy usingSleeping Beautyto genetically modify clinical-grade T cells to target CD19

(2013) Harjeet Singh et al.   IMMUNOLOGICAL REVIEWS

Differences in the Phenotype, Cytokine Gene Expression Profiles, and In Vivo Alloreactivity of T Cells Mobilized with Plerixafor Compared with G-CSF

(2013) A. Lundqvist et al.   JOURNAL OF IMMUNOLOGY

Perspective: Assembly line immunotherapy

(2013) Bruce L. Levine et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

(2013) Harjeet Singh et al.   PLoS One

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

Lentiviral vectors: basic to translational

(2012) Toshie Sakuma et al.   BIOCHEMICAL JOURNAL

Targeted immunotherapy of cancer with CAR T cells: achievements and challenges

(2012) Grazyna Lipowska-Bhalla et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anticoagulation techniques in apheresis: From heparin to citrate and beyond

(2012) Grace Lee et al.   JOURNAL OF CLINICAL APHERESIS

Bioreactors get personal

(2012) Robert P.T. Somerville et al.   OncoImmunology

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

(2011) Barbara Savoldo et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens

(2011) Laurent Boissel et al.   LEUKEMIA & LYMPHOMA

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

The Inside Out of Lentiviral Vectors

(2011) Stéphanie Durand et al.   Viruses-Basel

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

T-cell-based Therapies for Malignancy and Infection in Childhood

(2010) Nabil Ahmed et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Expansion and Characterization of Human Melanoma Tumor-Infiltrating Lymphocytes (TILs)

(2010) Linh T. Nguyen et al.   PLoS One

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)

(2009) I. M. Borrello et al.   BLOOD

Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program

(2009) Daniel J. Powell et al.   CYTOTHERAPY

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

(2009) Daniel Hollyman et al.   JOURNAL OF IMMUNOTHERAPY

Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T Cells

(2009) Gary P Wang et al.   MOLECULAR THERAPY

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

Moderate and severe adverse events associated with apheresis donations: incidences and risk factors

(2009) Shan Yuan et al.   TRANSFUSION

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

(2008) B. G. Till et al.   BLOOD

T lymphocyte engineeringex vivofor cancer and infectious disease

(2008) Bruce L Levine   EXPERT OPINION ON BIOLOGICAL THERAPY